The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

sulindac

Synonyms

(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

sulindaco

C20H17FO3S

cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid

Sulindac

Sulindacum

sulindac

2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid

Clinoril

ID

http://purl.obolibrary.org/obo/CHEBI_9352

AHFScode

28:08.04.92

ATCCode

M01AB02

blocks

http://purl.obolibrary.org/obo/dinto_0423

CASRN

38194-50-2

DBBrand

clinoril

DBname

sulindac

Definition

A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.

has effect

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000979

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000438

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001209

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001707

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001168

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000811

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0001298

http://purl.obolibrary.org/obo/OAE_0001463

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000752

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0001336

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000395

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000882

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001366

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2116

has role

http://purl.obolibrary.org/obo/CHEBI_35480

http://purl.obolibrary.org/obo/CHEBI_66993

http://purl.obolibrary.org/obo/CHEBI_50266

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_35544

http://purl.obolibrary.org/obo/CHEBI_35475

http://purl.obolibrary.org/obo/CHEBI_35493

http://purl.obolibrary.org/obo/CHEBI_35481

http://purl.obolibrary.org/obo/CHEBI_68495

InChI

InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChIKey

InChIKey=MLKXDPUZXIRXEP-MFOYZWKCSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_0550

http://purl.obolibrary.org/obo/dinto_2116

http://purl.obolibrary.org/obo/dinto_0269

http://purl.obolibrary.org/obo/dinto_2716

http://purl.obolibrary.org/obo/dinto_0938

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_2651

label

sulindac

may interact with

http://purl.obolibrary.org/obo/dinto_DB00519

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/dinto_DB01399

http://purl.obolibrary.org/obo/CHEBI_9434

http://purl.obolibrary.org/obo/dinto_DB00465

http://purl.obolibrary.org/obo/dinto_DB01398

http://purl.obolibrary.org/obo/dinto_DB01432

http://purl.obolibrary.org/obo/CHEBI_47426

http://purl.obolibrary.org/obo/dinto_DB01381

http://purl.obolibrary.org/obo/dinto_DB00373

http://purl.obolibrary.org/obo/CHEBI_59594

http://purl.obolibrary.org/obo/CHEBI_44185

http://purl.obolibrary.org/obo/CHEBI_4876

http://purl.obolibrary.org/obo/CHEBI_27565

http://purl.obolibrary.org/obo/dinto_DB01404

http://purl.obolibrary.org/obo/CHEBI_63723

http://purl.obolibrary.org/obo/CHEBI_68845

http://purl.obolibrary.org/obo/CHEBI_71223

http://purl.obolibrary.org/obo/CHEBI_15365

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/CHEBI_53766

http://purl.obolibrary.org/obo/CHEBI_3213

http://purl.obolibrary.org/obo/CHEBI_15414

http://purl.obolibrary.org/obo/CHEBI_59602

http://purl.obolibrary.org/obo/CHEBI_50861

prefixIRI

obo2:CHEBI_9352

prefLabel

sulindac

related with

http://purl.obolibrary.org/obo/dinto_0217

http://purl.obolibrary.org/obo/dinto_1874

SMILES

CC1=C(CC(O)=O)C2=CC(F)=CC=C2C1=C/C1=CC=C(C=C1)S(C)=O

CC1=C(CC(O)=O)c2cc(F)ccc2C\1=C/c1ccc(cc1)S(C)=O

Synonym

(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

sulindaco

C20H17FO3S

cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid

{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid

Sulindac

Sulindacum

sulindac

2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid

Clinoril

xref

CiteXplore:15123337

CiteXplore:23689354

CiteXplore:11569947

CiteXplore:19884509

Wikipedia:http://en.wikipedia.org/wiki/Sulindac

Patent:DE2039426

Drugs Product Database (DPD):808636

KEGG COMPOUND:C01531

Beilstein:2951842

PDBeChem:SUZ

RxList:http://www.rxlist.com/cgi/generic3/sulindac.htm

PharmGKB:PA451565

CiteXplore:23804703

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cli1087.shtml

DrugBank:DB00605

HMDB:HMDB14743

National Drug Code Directory:0006-0941-68

KEGG DRUG:D00120

Patent:US3654349

CASRN:38194-50-2

Drugs.com:http://www.drugs.com/cdi/sulindac.html

CiteXplore:15020200

ChEBI:9352

Wikipedia:Sulindac

ChEMBL:116510

NIST Chemistry WebBook:38194-50-2

CiteXplore:11927004

CiteXplore:12406542

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013467 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11881 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146307 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Sulindac GALEN LOOM
http://purl.bioontology.org/ontology/RCD/j2f.. RCD LOOM
http://scai.fraunhofer.de/AlzheimerOntology#sulindac ADO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C850 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0038792 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.486.875 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D013467 MESH LOOM
http://stirdf.jst.go.jp/id/200907040615001920 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017957 VANDF LOOM
http://data.bnf.fr/ark:/12148/cb12562840g FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041538 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP18100-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.486.875 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9352 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_9352 NIFSTD SAME_URI
http://d-nb.info/gnd/4358401-9 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RXNORM/10237 RXNORM LOOM
http://id.loc.gov/authorities/subjects/sh85130323 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387513000 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906008974470052 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003386 LOINC LOOM
http://www.drugbank.ca/drugs/DB00605 FTC LOOM
http://purl.bioontology.org/ontology/SNMI/C-60440 SNMI LOOM
http://purl.bioontology.org/ontology/UATC/M01AB02 ATC LOOM