The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Jump to:
loading...
Preferred Name

sildenafil
Synonyms

1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine

C22H30N6O4S

5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

5-[2-ethoxy-5-(4-methylpiperazine-1-sulfonyl)phenyl]-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one

sildenafil
ID

http://purl.obolibrary.org/obo/CHEBI_9139
AHFScode

24:12.12
altId

CHEBI:46436

CHEBI:600437
ATCCode

G04BE03
CASRN

139755-83-2
DBBrand

viagra

revatio
DBname

sildenafil
DBSynonym

sildenafil citrate
Definition

A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0001297

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000785

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000589

http://purl.obolibrary.org/obo/OAE_0000573

http://purl.obolibrary.org/obo/OAE_0000236

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000617

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000493

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0000611

http://purl.obolibrary.org/obo/OAE_0001360

http://purl.obolibrary.org/obo/OAE_0000801

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000577

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001013

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000465

http://purl.obolibrary.org/obo/OAE_0001268

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0000935

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000518

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000691

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0001234

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0001420

http://purl.obolibrary.org/obo/OAE_0000671

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0001295

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0001190

http://purl.obolibrary.org/obo/OAE_0001374

http://purl.obolibrary.org/obo/OAE_0001142

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000510

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000789

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000344

http://purl.obolibrary.org/obo/OAE_0001202

http://purl.obolibrary.org/obo/OAE_0000495

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000405

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000185

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000470

http://purl.obolibrary.org/obo/OAE_0000514

http://purl.obolibrary.org/obo/OAE_0000501

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001458

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350

http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target

http://purl.obolibrary.org/obo/dinto_1637
has role

http://purl.obolibrary.org/obo/CHEBI_35620

http://purl.obolibrary.org/obo/CHEBI_71942
InChI

InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
InChIKey

InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_1973

http://purl.obolibrary.org/obo/dinto_1637

http://purl.obolibrary.org/obo/dinto_1992

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0458

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0269

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0460

http://purl.obolibrary.org/obo/dinto_0300
is metabolised by

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1956
label

sildenafil
may interact with

http://purl.obolibrary.org/obo/CHEBI_37924

http://purl.obolibrary.org/obo/dinto_DB00224

http://purl.obolibrary.org/obo/CHEBI_40050

http://purl.obolibrary.org/obo/CHEBI_71253

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/dinto_DB01167

http://purl.obolibrary.org/obo/CHEBI_681850

http://purl.obolibrary.org/obo/CHEBI_9445

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_100241

http://purl.obolibrary.org/obo/CHEBI_28787

http://purl.obolibrary.org/obo/CHEBI_3732

http://purl.obolibrary.org/obo/CHEBI_63628

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/CHEBI_6062

http://purl.obolibrary.org/obo/CHEBI_6061

http://purl.obolibrary.org/obo/dinto_DB01319

http://purl.obolibrary.org/obo/CHEBI_63638

http://purl.obolibrary.org/obo/dinto_DB01026

http://purl.obolibrary.org/obo/dinto_DB00220

http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI

obo2:CHEBI_9139
prefLabel

sildenafil
SMILES

CCCC1=NN(C)C2=C1NC(=NC2=O)C1=C(OCC)C=CC(=C1)S(=O)(=O)N1CCN(C)CC1

CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Synonym

1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine

C22H30N6O4S

5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

5-[2-ethoxy-5-(4-methylpiperazine-1-sulfonyl)phenyl]-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one

sildenafil
xref

CASRN:139755-83-2

PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam

ChEMBL:510802

Wikipedia:http://en.wikipedia.org/wiki/Sildenafil

ChEBI:9139

DrugBank:DB00203

Patent:US5250534

Patent:EP463756

National Drug Code Directory:0069-4190-68

KEGG DRUG:D08514

Drugs.com:http://www.drugs.com/cdi/sildenafil.html

Beilstein:7673458

ChemSpider:5023

PharmGKB:PA451346

BindingDB:14390

PDBeChem:VIA

RxList:http://www.rxlist.com/cgi/generic/viagra.htm

PubChem Compound:5212

PubChem Substance:46508371

KEGG COMPOUND:C07259

Wikipedia:Sildenafil

Drugs Product Database (DPD):2239766
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_9139 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9139 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9139 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9139 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9139 GSSO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9139 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9139 CHEBI LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61940 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0529793 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38449 OCHV LOOM
https://go.drugbank.com/drugs/DB00203 MDM LOOM
http://purl.obolibrary.org/obo/DRON_00018221 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C61940 BERO LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Sildenafil STMSO LOOM
http://stirdf.jst.go.jp/id/200907020425917537 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/136411 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/G04BE03 ATC LOOM
http://purl.bioontology.org/ontology/RCD/gh5.. RCD LOOM
http://www.drugbank.ca/drugs/DB00203 FTC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0529793 HFO LOOM
http://purl.bioontology.org/ontology/VANDF/4024110 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/007448 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_9139 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_9139 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_9139 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9139 GSSO LOOM
http://purl.obolibrary.org/obo/CHEBI_9139 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C101426 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022115 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372572000 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906069258394743 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Sildenafil GALEN LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000022115 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000022115 OCVDAE LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Sildenafil APAONTO LOOM