The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	rivastigmine
Synonyms	3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate rivastigmine m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate C14H22N2O2 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
ID	http://purl.obolibrary.org/obo/CHEBI_8874
AHFScode	12:04.00
ATCCode	N06DA03
CASRN	123441-03-2
DBBrand	exelon exelon patch
DBname	rivastigmine
DBSynonym	ena 713 free base
Definition	A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000424 http://purl.obolibrary.org/obo/OAE_0001285 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000356 http://purl.obolibrary.org/obo/OAE_0000573 http://purl.obolibrary.org/obo/OAE_0000236 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0000817 http://purl.obolibrary.org/obo/OAE_0000838 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0001098 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0001045 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0000900 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000967 http://purl.obolibrary.org/obo/OAE_0000465 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000205 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0001436 http://purl.obolibrary.org/obo/OAE_0001751 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000762 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001229 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000984 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0000207 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0000518 http://purl.obolibrary.org/obo/OAE_0001063 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000863 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001433 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000642 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0000895 http://purl.obolibrary.org/obo/OAE_0000687 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000502 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0000671 http://purl.obolibrary.org/obo/OAE_0001003 http://purl.obolibrary.org/obo/OAE_0001014 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000911 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000772 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000475 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0001004 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001202 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0001429 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000302 http://purl.obolibrary.org/obo/OAE_0001356 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000701 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0001077 http://purl.obolibrary.org/obo/OAE_0000296 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000346 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0000488 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000885 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000581 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001298 http://purl.obolibrary.org/obo/OAE_0000350 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3568 http://purl.obolibrary.org/obo/dinto_1021
has role	http://purl.obolibrary.org/obo/CHEBI_38323 http://purl.obolibrary.org/obo/CHEBI_37733 http://purl.obolibrary.org/obo/CHEBI_63726
InChI	InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
InChIKey	InChIKey=XSVMFMHYUFZWBK-NSHDSACASA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_3568 http://purl.obolibrary.org/obo/dinto_1021
label	rivastigmine
prefixIRI	obo2:CHEBI_8874
prefLabel	rivastigmine
SMILES	CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C
Synonym	3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate rivastigmine m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate C14H22N2O2 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
xref	CiteXplore:22290743 PubChem Substance:46507452 CiteXplore:20070789 CiteXplore:22195801 PubChem Compound:77991 CiteXplore:22163242 CiteXplore:22010358 Wikipedia:http://en.wikipedia.org/wiki/Rivastigmine CiteXplore:22163241 PharmGKB:PA451262 CiteXplore:21246897 ChEMBL:127251 Patent:US2009298817 Reaxys:7875788 CiteXplore:22409834 CiteXplore:20370805 CiteXplore:22451057 CiteXplore:22362231 RxList:http://www.rxlist.com/cgi/generic2/rivastig.htm CiteXplore:22054233 ChemSpider:70377 CiteXplore:22068922 Drugs.com:http://www.drugs.com/cdi/rivastigmine.html Patent:DE3805744 DrugBank:DB00989 KEGG DRUG:D03822 BindingDB:10620 CiteXplore:19370562 CiteXplore:22230648 CiteXplore:19619073 Patent:EP1980552 CiteXplore:21996001 CiteXplore:22009228 CiteXplore:19392927 CASRN:123441-03-2 CiteXplore:20865460 Wikipedia:Rivastigmine CiteXplore:22087207 Drugs Product Database (DPD):2242118 CiteXplore:22163243 CiteXplore:22173266 Patent:US2008255383 Patent:EP2233465 CiteXplore:19893314 CiteXplore:22230878 CiteXplore:19032006 CiteXplore:21131668 CiteXplore:22044027 KEGG COMPOUND:C11766 National Drug Code Directory:0078-0501-15 CiteXplore:22224039 Patent:US5602176 CiteXplore:21977379
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_8874	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8874	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8874	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8874	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8874	CHEBI	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0649350	OCHV	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Rivastigmine	STMSO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016367	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0001335	OMIT	LOOM
http://purl.obolibrary.org/obo/MESH_D000068836	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8874	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8874	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8874	DRON	LOOM
http://purl.bioontology.org/ontology/MESH/D000068836	MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/183379	RXNORM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395868008	SNOMEDCT	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Rivastigmine	ADO	LOOM
http://purl.obolibrary.org/obo/NCIT_C66519	BERO	LOOM
http://doe-generated-ontology.com/OntoAD#C0649350	ONTOAD	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148665	NDFRT	LOOM
http://purl.bioontology.org/ontology/NDDF/007559	NDDF	LOOM
http://stirdf.jst.go.jp/id/200907034243349739	IOBC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66519	NCIT	LOOM
http://www.drugbank.ca/drugs/DB00989	FTC	LOOM
http://purl.bioontology.org/ontology/RCD/dy2..	RCD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C072506	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB00989	MDM	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148665	ODAE	LOOM
http://purl.jp/bio/4/id/200906083725417739	IOBC	LOOM
http://purl.obolibrary.org/obo/DRON_00016899	ODNAE	LOOM
http://purl.bioontology.org/ontology/ATC/N06DA03	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42480	OCHV	LOOM
http://purl.bioontology.org/ontology/VANDF/4021219	VANDF	LOOM
http://www.co-ode.org/ontologies/galen#Rivastigmine	GALEN	LOOM