loading...| Preferred Name |
paromomycin |
|
| Synonyms |
R-400 Zygomycin A1 paromomycinum R 400 paucimycinum estomycin crestomycin (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside PAROMOMYCIN Monomycin A Paromomycin paucimycin Catenulin paromomicina paromomycin hydroxymycin C23H45N5O14 paromomycine Aminosidin neomycin E Hydroxymycin (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol aminosidine |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_7934 |
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| AHFScode |
08:30.04 |
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| altId |
CHEBI:44703 |
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| ATCCode |
A07AA06 |
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| CASRN |
1263-89-4 |
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| DBBrand |
humatin |
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| DBname |
paromomycin |
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| DBSynonym |
aminosidin paramomycin sulfate aminosidine |
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| Definition |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. |
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| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35820 http://purl.obolibrary.org/obo/CHEBI_36047 |
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| InChI |
InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1 |
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| InChIKey |
InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N |
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| inhibits | ||
| label |
paromomycin |
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| prefixIRI |
obo2:CHEBI_7934 |
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| prefLabel |
paromomycin |
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| SMILES |
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |
|
| Synonym |
R-400 Zygomycin A1 paromomycinum R 400 paucimycinum estomycin crestomycin (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside PAROMOMYCIN Monomycin A Paromomycin paucimycin Catenulin paromomicina paromomycin hydroxymycin C23H45N5O14 paromomycine Aminosidin neomycin E Hydroxymycin (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxane-3,4-diol aminosidine |
|
| xref |
CiteXplore:18947845 National Drug Code Directory:61570-529-10 Patent:US2895876 KEGG COMPOUND:C00832 Drugs.com:http://www.drugs.com/cdi/paromomycin.html RxList:http://www.rxlist.com/cgi/generic/humatin.htm PharmGKB:PA164784023 Drugs Product Database (DPD):2078759 ChemSpider:145115 CiteXplore:18447603 KEGG DRUG:D07467 Wikipedia:http://en.wikipedia.org/wiki/Paromomycin_sulfate CASRN:7542-37-2 ChEMBL:425236 CiteXplore:8036682 PDBeChem:PAR Reaxys:72285 PubChem Substance:46505391 DrugBank:DB01421 Patent:US2916485 PubChem Compound:165580 |
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| subClassOf |