loading...| Preferred Name |
fluticasone furoate |
|
| Synonyms |
Veramyst (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0?,?.0??,??]heptadeca-3,6-dien-14-yl furan-2-carboxylate furoato de fluticasona furoate de fluticasone 6alpha,9-difluoro-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-11beta-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17alpha-yl 2-furoate C27H29F3O6S GSK 685698 fluticasonum furoas fluticasone furoate |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_74899 |
|
| activates | ||
| ATCCode |
R01AD12 |
|
| CASRN |
397864-44-7 |
|
| DBBrand |
avamys veramyst |
|
| Definition |
Fluticasone furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. Despite the similarity in the names, fluticasone furoate and fluticasone propionate are different drugs with different properties. It is marketed under the brand name, Veramyst in the US by GlaxoSmithKline for the management of chronic obstructive pulmonary disease (COPD). FDA approved on April 27, 2007. A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000900 http://purl.obolibrary.org/obo/OAE_0001073 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000353 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000344 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000211 |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_50266 |
|
| InChI |
InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1 |
|
| InChIKey |
InChIKey=XTULMSXFIHGYFS-VLSRWLAYSA-N |
|
| is metabolised by | ||
| is transported by | ||
| label |
fluticasone furoate |
|
| may interact with | ||
| prefixIRI |
obo2:CHEBI_74899 |
|
| prefLabel |
fluticasone furoate |
|
| SMILES |
[H][C@@]12C[C@@H](C)[C@](OC(=O)C3=CC=CO3)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C [H][C@@]12C[C@@H](C)[C@](OC(=O)c3ccco3)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C |
|
| Synonym |
Veramyst (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0?,?.0??,??]heptadeca-3,6-dien-14-yl furan-2-carboxylate furoato de fluticasona furoate de fluticasone 6alpha,9-difluoro-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-11beta-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17alpha-yl 2-furoate C27H29F3O6S GSK 685698 fluticasonum furoas fluticasone furoate |
|
| xref |
CiteXplore:22342538 CiteXplore:22391079 CiteXplore:23806459 CiteXplore:23578031 CiteXplore:23548539 Wikipedia:Fluticasone_furoate CiteXplore:22738148 Reaxys:15686794 CiteXplore:23116485 CiteXplore:23719680 CiteXplore:23332861 CiteXplore:23200625 Drugs.com:http://www.drugs.com/cdi/fluticasone-furoate-spray.html KEGG DRUG:D06315 CiteXplore:23184737 CiteXplore:22387656 CiteXplore:22170807 CASRN:397864-44-7 Wikipedia:http://en.wikipedia.org/wiki/Fluticasone_furoate CiteXplore:22614920 CiteXplore:23846316 CiteXplore:23735179 Patent:WO2011151624 RxList:http://www.rxlist.com/veramyst-drug.htm CiteXplore:23821392 Patent:WO2010016931 CiteXplore:23676578 Patent:WO2012160338 National Drug Code Directory:54868-6168-0 CiteXplore:23406601 ChEMBL:608532 PDBeChem:GW6 CiteXplore:23018908 CiteXplore:23352226 CiteXplore:23440247 Patent:WO2011151625 CiteXplore:21828231 Patent:US2009118495 |
|
| subClassOf |