The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	naproxen
Synonyms	naproxeno (S)-2-(6-Methoxy-2-naphthyl)propanoic acid naproxen (+)-Naproxen Naproxen (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid (+)-2-(Methoxy-2-naphthyl)-propionsaeure (S)-2-(6-Methoxy-2-naphthyl)propionic acid (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid naproxenum naproxene (+)-(S)-Naproxen (+)-2-(6-Methoxy-2-naphthyl)propionic acid (S)-Naproxen C14H14O3 (S)-(+)-Naproxen (+)-2-(Methoxy-2-naphthyl)-propionic acid
ID	http://purl.obolibrary.org/obo/CHEBI_7476
AHFScode	28:08.04.92
altId	CHEBI:603695
ATCCode	M01AE02 G02CC02 M02AA12
CASRN	22204-53-1
DBBrand	veradol laser prexan bonyl mnpa dl naproxen proxen napren panoxen naprosyne reuxen dysmenalgit naprelan naprosyn naproxen sodium naprium naprius diocodal equiproxen pranoxen nycopren floginax xenar naprosine dl-naproxen aleve niaxan proxine anaprox naxyn naxen naprux ec-naprosyn naixan laraflex
DBname	naproxen
Definition	A non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000447 http://purl.obolibrary.org/obo/OAE_0000424 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000236 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000967 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0000465 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0001280 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0001168 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0000518 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000502 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001003 http://purl.obolibrary.org/obo/OAE_0001014 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001295 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000438 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001343 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0001202 http://purl.obolibrary.org/obo/OAE_0000495 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000917 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0001429 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000405 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0001209 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000404 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000347 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001170 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001497 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811 http://purl.obolibrary.org/obo/OAE_0000506 http://purl.obolibrary.org/obo/OAE_0000350 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_2116
has role	http://purl.obolibrary.org/obo/CHEBI_35493 http://purl.obolibrary.org/obo/CHEBI_35845 http://purl.obolibrary.org/obo/CHEBI_50629 http://purl.obolibrary.org/obo/CHEBI_35475 http://purl.obolibrary.org/obo/CHEBI_35481 http://purl.obolibrary.org/obo/CHEBI_50630
InChI	InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
InChIKey	InChIKey=CMWTZPSULFXXJA-VIFPVBQESA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_0520 http://purl.obolibrary.org/obo/dinto_2116
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_1890 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0276
label	naproxen
may interact with	http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/dinto_DB08814 http://purl.obolibrary.org/obo/CHEBI_9434 http://purl.obolibrary.org/obo/CHEBI_44185 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB00373 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB06204 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/CHEBI_72296 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_70707 http://purl.obolibrary.org/obo/CHEBI_71223 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_68845 http://purl.obolibrary.org/obo/dinto_DB01381 http://purl.obolibrary.org/obo/CHEBI_2567
prefixIRI	obo2:CHEBI_7476
prefLabel	naproxen
related with	http://purl.obolibrary.org/obo/dinto_0217
SMILES	COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O COC1=CC2=C(C=C1)C=C(C=C2)[C@H](C)C(O)=O
Synonym	naproxeno (S)-2-(6-Methoxy-2-naphthyl)propanoic acid naproxen (+)-Naproxen Naproxen (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid (+)-2-(Methoxy-2-naphthyl)-propionsaeure (S)-2-(6-Methoxy-2-naphthyl)propionic acid (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid naproxenum naproxene (+)-(S)-Naproxen (+)-2-(6-Methoxy-2-naphthyl)propionic acid (S)-Naproxen C14H14O3 (S)-(+)-Naproxen (+)-2-(Methoxy-2-naphthyl)-propionic acid
xref	PharmGKB:PA450595 Wikipedia:Naproxen Patent:US4009197 CASRN:22204-53-1 BindingDB:50009860 ChEMBL:151056 Drugs.com:http://www.drugs.com/naproxen.html ChEMBL:9784154 Drugs Product Database (DPD):618721 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ana1021.shtml DrugBank:DB00788 Wikipedia:http://en.wikipedia.org/wiki/Naproxen Beilstein:3591067 RxList:http://www.rxlist.com/cgi/generic/naproxsod.htm Patent:US3904682 KEGG DRUG:D00118 National Drug Code Directory:0004-6313-01 ChEBI:7476
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_7476	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7476	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7476	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7476	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7476	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7476	DRON	SAME_URI
http://purl.obolibrary.org/obo/XCO_0001193	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7476	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7476	CHEBI	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040222	PDQ	LOOM
http://purl.bioontology.org/ontology/SNMI/C-60410	SNMI	LOOM
http://purl.bioontology.org/ontology/VANDF/4018847	VANDF	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Naproxen	STMSO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016946	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372588000	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/M02AA12	ATC	LOOM
http://purl.obolibrary.org/obo/NCIT_C680	BERO	LOOM
http://purl.bioontology.org/ontology/RCD/j2c..	RCD	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00347	COID	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#naproxen	ADO	LOOM
http://bmi.utah.edu/ontologies/peontology/C0027396	RAO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.472.500	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_7476	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7476	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7476	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_7476	DRON	LOOM
http://www.co-ode.org/ontologies/galen#Naproxen	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009288	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP16215-3	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/G02CC02	ATC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147149	NDFRT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU015374	LOINC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027396	OCHV	LOOM
http://purl.obolibrary.org/obo/OMIT_0010322	OMIT	LOOM
https://go.drugbank.com/drugs/DB00788	MDM	LOOM
http://purl.bioontology.org/ontology/MESH/D009288	MESH	LOOM
http://purl.jp/bio/4/id/200906020191518869	IOBC	LOOM
http://purl.bioontology.org/ontology/CSP/4001-0089	CRISP	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C680	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/7258	RXNORM	LOOM
http://purl.bioontology.org/ontology/NDDF/002380	NDDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8483	OCHV	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:03045	MIO	LOOM
http://doe-generated-ontology.com/OntoAD#C0027396	ONTOAD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.472.450	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/M01AE02	ATC	LOOM
http://stirdf.jst.go.jp/id/200907067016753227	IOBC	LOOM
http://purl.obolibrary.org/obo/MESH_D009288	BERO	LOOM
http://www.drugbank.ca/drugs/DB00788	FTC	LOOM