The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	naltrexone
Synonyms	naltrexone N-Cyclopropylmethylnoroxymorphone C20H23NO4 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one N-Cyclopropylmethyl-14-hydroxydihydromorphinone Naltrexone 3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one
ID	http://purl.obolibrary.org/obo/CHEBI_7465
AHFScode	28:10.00
ATCCode	N07BB04
blocks	http://purl.obolibrary.org/obo/dinto_0760 http://purl.obolibrary.org/obo/dinto_2787 http://purl.obolibrary.org/obo/dinto_1136 http://purl.obolibrary.org/obo/dinto_3960
CASRN	16590-41-3
DBBrand	vivitrex naltrexonum [inn-latin] revia naltrexone hcl n-cyclopropylmethylnoroxymorphone naltrexone [usan:ban:inn] morviva naltrexona [inn-spanish] celupan
DBname	naltrexone
DBSynonym	pti-555
Definition	A morphinane alkaloid that has formula C20H23NO4.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000599 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000817 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001273 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001457 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001751 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000281 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001229 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000883 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000646 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001433 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000353 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000502 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001461 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000320 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000344 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000022 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000296 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000346 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0760 http://purl.obolibrary.org/obo/dinto_2787 http://purl.obolibrary.org/obo/dinto_1136 http://purl.obolibrary.org/obo/dinto_3960
has role	http://purl.obolibrary.org/obo/CHEBI_50137 http://purl.obolibrary.org/obo/CHEBI_35488
InChI	InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
InChIKey	InChIKey=DQCKKXVULJGBQN-XFWGSAIBSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_0276
label	naltrexone
prefixIRI	obo2:CHEBI_7465
prefLabel	naltrexone
SMILES	[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC1CC1
Synonym	naltrexone N-Cyclopropylmethylnoroxymorphone C20H23NO4 17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one N-Cyclopropylmethyl-14-hydroxydihydromorphinone Naltrexone 3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one
xref	Beilstein:3596648 National Drug Code Directory:0555-0902-01 Patent:US3332950 RxList:http://www.rxlist.com/cgi/generic2/naltrexone.htm ChEMBL:121459 PubChem Substance:46505333 DrugBank:DB00704 Wikipedia:http://en.wikipedia.org/wiki/Naltrexone KEGG DRUG:D05113 Drugs.com:http://www.drugs.com/cdi/naltrexone.html PharmGKB:PA450588 ChemSpider:4514524 PubChem Compound:5360515 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/rev1376.shtml Drugs Product Database (DPD):2213826 ChEBI:7465 CASRN:16590-41-3 KEGG COMPOUND:C07253
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_7465	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7465	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7465	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7465	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7465	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7465	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_7465	CHEBI	LOOM
http://www.drugbank.ca/drugs/DB00704	FTC	LOOM
http://stirdf.jst.go.jp/id/200907019731414788	IOBC	LOOM
http://purl.jp/bio/4/id/200906073911164420	IOBC	LOOM
https://go.drugbank.com/drugs/DB00704	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8473	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.723.795.706.550	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0010305	OMIT	LOOM
http://purl.bioontology.org/ontology/ATC/N07BB04	ATC	LOOM
http://purl.bioontology.org/ontology/RCD/x01GR	RCD	LOOM
http://purl.obolibrary.org/obo/NCIT_C62055	BERO	LOOM
http://www.co-ode.org/ontologies/galen#Naltrexone	GALEN	LOOM
http://purl.obolibrary.org/obo/CHEBI_7465	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7465	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7465	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_7465	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_7465	NIFSTD	LOOM
http://purl.bioontology.org/ontology/NDDF/004662	NDDF	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147939	NDFRT	LOOM
http://purl.bioontology.org/ontology/VANDF/4019853	VANDF	LOOM
http://purl.bioontology.org/ontology/CSP/0092-7374	CRISP	LOOM
http://purl.bioontology.org/ontology/LNC/LP15000-0	LOINC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62055	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/7243	RXNORM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.577.249.706.550	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.549.686.750.550	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002303	LOINC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373546002	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/MESH_D009271	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.497.750.550	RH-MESH	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass9a587443_7cc8_4915_a6bb_b7813fba79b7	WWECA	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018045	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027360	OCHV	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Naltrexone	APAONTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009271	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D009271	MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-60D20	SNMI	LOOM