The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

temozolomide

Synonyms

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

C6H6N6O2

M&B 39831

temozolomidum

Sch 52365

MB 39831

CCRG 81045

methazolastone

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

NSC 362856

Temodar

M & B 39831

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

CCRIS 8996

temozolomida

CCRG-81045

Temodal

TMZ

temozolomide

3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide

BRN 5547136

ID

http://purl.obolibrary.org/obo/CHEBI_72564

AHFScode

10:00.00

ATCCode

L01AX03

CASRN

85622-93-1

DBBrand

temodar

temodal

DBname

temozolomide

DBSynonym

methazolastone

temozolomidum [latin]

temozolodida [spanish]

temozolamide

Definition

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000424

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000573

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0001505

http://purl.obolibrary.org/obo/OAE_0001154

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001510

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0001744

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001167

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001449

http://purl.obolibrary.org/obo/OAE_0000801

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000205

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0001144

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000527

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000861

http://purl.obolibrary.org/obo/OAE_0000340

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001340

http://purl.obolibrary.org/obo/OAE_0001275

http://purl.obolibrary.org/obo/OAE_0000687

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000802

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000943

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0001014

http://purl.obolibrary.org/obo/OAE_0001295

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000526

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0001341

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000864

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000525

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0001198

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0001205

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000185

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000275

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000470

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000466

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001170

http://purl.obolibrary.org/obo/OAE_0000766

http://purl.obolibrary.org/obo/OAE_0001458

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000811

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2873

has role

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_22333

http://purl.obolibrary.org/obo/CHEBI_50266

InChI

InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChIKey

InChIKey=BPEGJWRSRHCHSN-UHFFFAOYSA-N

induces

http://purl.obolibrary.org/obo/dinto_0901

label

temozolomide

prefixIRI

obo2:CHEBI_72564

prefLabel

temozolomide

related with

http://purl.obolibrary.org/obo/dinto_2873

SMILES

CN1N=NC2=C(N=CN2C1=O)C(N)=O

Cn1nnc2c(ncn2c1=O)C(N)=O

Synonym

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

C6H6N6O2

M&B 39831

temozolomidum

Sch 52365

MB 39831

CCRG 81045

methazolastone

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

NSC 362856

Temodar

M & B 39831

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

CCRIS 8996

temozolomida

CCRG-81045

Temodal

TMZ

temozolomide

3-methyl-4-oxo-3H,4H-imidazo[4,3-d][1,2,3,5]tetrazine-8-carboxamide

BRN 5547136

xref

Reaxys:5547136

CASRN:85622-93-1

CiteXplore:23362460

CiteXplore:23254891

CiteXplore:22818211

PharmGKB:PA451609

Wikipedia:Temozolomide

CiteXplore:22680781

CiteXplore:23377829

PubChem Substance:46507934

HMDB:HMDB14991

PubChem Compound:5394

CiteXplore:23335050

ChemSpider:5201

CiteXplore:23385995

Wikipedia:http://en.wikipedia.org/wiki/Temozolomide

KEGG DRUG:D06067

CiteXplore:23293540

Drugs.com:http://www.drugs.com/cdi/temozolomide.html

RxList:http://www.rxlist.com/cgi/generic2/temoz.htm

Patent:DE3231255

ChEMBL:153686

National Drug Code Directory:0085-3004-02

DrugBank:DB00853

CiteXplore:23389760

Drugs Product Database (DPD):2241094

BindingDB:50034562

CiteXplore:23246370

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_72564 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 OBA LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047246 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907074216809916 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D000077204 MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041671 PDQ LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148622 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C1244 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/007794 NDDF LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026296 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/CSP/4008-0098 CRISP LOOM
http://www.ifomis.org/acgt/1.0#Temozolomide ACGT-MO LOOM
https://go.drugbank.com/drugs/DB00853 MDM LOOM
http://www.co-ode.org/ontologies/galen#Temozolomide GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/37776 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.bioontology.org/ontology/VANDF/4021173 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14908 OCHV LOOM
http://purl.jp/bio/4/id/200906010256487782 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/L01AX03 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0076080 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387009002 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1244 NCIT LOOM