The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

alogliptin

Synonyms

alogliptinum

C18H21N5O2

alogliptina

alogliptine

2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile

alogliptin

ID

http://purl.obolibrary.org/obo/CHEBI_72323

AHFScode

68:20.05

ATCCode

A10BH04

CASRN

850649-61-5

DBBrand

nesina

DBSalt

alogliptin benzoate

DBSynonym

syr-322

Definition

A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of type 2 diabetes.

Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2272

has role

http://purl.obolibrary.org/obo/CHEBI_68612

http://purl.obolibrary.org/obo/CHEBI_35526

InChI

InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1

InChIKey

InChIKey=ZSBOMTDTBDDKMP-OAHLLOKOSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2272

is metabolised by

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

label

alogliptin

prefixIRI

obo2:CHEBI_72323

prefLabel

alogliptin

SMILES

Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O

CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O

Synonym

alogliptinum

C18H21N5O2

alogliptina

alogliptine

2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile

2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile

alogliptin

xref

CiteXplore:21397040

CiteXplore:23289982

CiteXplore:22106975

CiteXplore:22296609

CiteXplore:22419732

CiteXplore:23220949

CiteXplore:20040339

CiteXplore:21682833

RxList:http://www.rxlist.com/nesina-drug/patient-images-side-effects.htm

Drugs.com:http://www.drugs.com/mtm/alogliptin.html

CiteXplore:21558879

CiteXplore:21806314

CiteXplore:22249941

CiteXplore:23298374

Patent:EP1970063

ChEMBL:477721

CiteXplore:22237690

Patent:WO2010072680

Reaxys:10587993

ChEBI:72323

CiteXplore:22162539

CiteXplore:22512582

CiteXplore:22583697

Patent:US2007066635

National Drug Code Directory:64764-250-30

CiteXplore:21733058

Patent:US2009275750

CiteXplore:22832924

Patent:WO2008028914

CiteXplore:21595275

CASRN:850649-61-5

CiteXplore:21431099

CiteXplore:21205126

Wikipedia:http://en.wikipedia.org/wiki/Alogliptin

CiteXplore:22651127

CiteXplore:22429011

Wikipedia:Alogliptin

Patent:WO2009022009

CiteXplore:21595274

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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