The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

metronidazole

Synonyms

2-methyl-5-nitroimidazole-1-ethanol

2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole

2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol

1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole

1-(beta-oxyethyl)-2-methyl-5-nitroimidazole

metronidazole

C6H9N3O3

1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole

1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole

metronidazol

1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole

2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol

2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole

metronidazolum

ID

http://purl.obolibrary.org/obo/CHEBI_6909

AHFScode

84:04.04

84:04.92

08:30.92

altId

CHEBI:63636

ATCCode

J01XD01

P01AB01

A01AB17

G01AF01

D06BX01

binds

http://purl.obolibrary.org/obo/dinto_2873

CASRN

443-48-1

DBBrand

trikacide

flagesol

eumin

trichocide

nalox

trikamon

metronidaz

trichopal

elyzol

metromidol

protostat

trimeks

meronidal

trichopol

metrolyl

mexibol

tricom

tricowas b

acromona

noritate

orvagil

metrogel

anagiardil

efloran

wagitran

bexon

deflamon-wirkstoff

vagilen

tricocet

danizol

metro cream

klion

monagyl

trikojol

zadstat

deflamon

metrolotion

giatricol

gineflavir

atrivyl

trivazol

apo-metronidazole

metro i.v.

trikozol

flagil

cont

tricho-gynaedron

entizol

fossyol

flagyl i.v.

flagyl

flagemona

bayer 5360

vagimid

satric

trichazol

flagyl er

tricho cordes

clont

nidagel

klont

metric 21

monasin

rathimed

neo-tric

vertisal

flegyl

takimetol

metro i.v. in plastic container

metrotop

metrogel-vaginal

arilin

novonidazol

nida

metrolag

trichex

sanatrichom

metrocream

trichomol

DBname

metronidazole

DBSynonym

metronidazole benzoate

metronidazole in plastic container

metronidazol

metronidazolo

metronidazole hcl

methronidazole

Definition

Imidazole substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000827

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001449

http://purl.obolibrary.org/obo/OAE_0001333

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001288

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000103

http://purl.obolibrary.org/obo/OAE_0001168

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000687

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0001105

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0000312

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000494

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000495

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000329

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0001356

http://purl.obolibrary.org/obo/OAE_0001205

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000336

http://purl.obolibrary.org/obo/OAE_0000800

http://purl.obolibrary.org/obo/OAE_0001147

http://purl.obolibrary.org/obo/OAE_0000701

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000346

http://purl.obolibrary.org/obo/OAE_0000242

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001170

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000049

http://purl.obolibrary.org/obo/OAE_0000350

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2873

http://purl.obolibrary.org/obo/dinto_1859

has role

http://purl.obolibrary.org/obo/CHEBI_47868

http://purl.obolibrary.org/obo/CHEBI_22582

http://purl.obolibrary.org/obo/CHEBI_50685

http://purl.obolibrary.org/obo/CHEBI_36047

http://purl.obolibrary.org/obo/CHEBI_35442

http://purl.obolibrary.org/obo/CHEBI_50266

InChI

InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

InChIKey

InChIKey=VAOCPAMSLUNLGC-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_3871

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221

is metabolised by

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_0901

label

metronidazole

may interact with

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_102524

http://purl.obolibrary.org/obo/dinto_DB00822

http://purl.obolibrary.org/obo/dinto_DB00794

http://purl.obolibrary.org/obo/CHEBI_28901

http://purl.obolibrary.org/obo/dinto_DB00306

http://purl.obolibrary.org/obo/CHEBI_40050

http://purl.obolibrary.org/obo/dinto_DB01355

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/CHEBI_102216

http://purl.obolibrary.org/obo/CHEBI_8069

http://purl.obolibrary.org/obo/dinto_DB00312

http://purl.obolibrary.org/obo/CHEBI_53766

http://purl.obolibrary.org/obo/dinto_DB01354

http://purl.obolibrary.org/obo/CHEBI_133809

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB00237

http://purl.obolibrary.org/obo/dinto_DB01352

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_6758

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/CHEBI_9622

http://purl.obolibrary.org/obo/CHEBI_9398

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/dinto_DB01351

http://purl.obolibrary.org/obo/CHEBI_4513

http://purl.obolibrary.org/obo/CHEBI_46345

http://purl.obolibrary.org/obo/dinto_DB01346

http://purl.obolibrary.org/obo/dinto_DB01353

http://purl.obolibrary.org/obo/dinto_DB01341

http://purl.obolibrary.org/obo/CHEBI_9073

prefixIRI

obo2:CHEBI_6909

prefLabel

metronidazole

related with

http://purl.obolibrary.org/obo/dinto_1859

SMILES

Cc1ncc(n1CCO)[N+]([O-])=O

CC1=NC=C(N1CCO)[N+]([O-])=O

Synonym

2-methyl-5-nitroimidazole-1-ethanol

2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole

2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol

1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole

1-(beta-oxyethyl)-2-methyl-5-nitroimidazole

metronidazole

C6H9N3O3

1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole

1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole

metronidazol

1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole

2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol

2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole

metronidazolum

xref

NIST Chemistry WebBook:443-48-1

Drugs Product Database (DPD):649074

CiteXplore:19485831

CiteXplore:14702395

KEGG DRUG:D00409

DrugBank:DB00916

Beilstein:611683

CiteXplore:16304169

PharmGKB:PA450484

CiteXplore:22252819

CiteXplore:15739364

ChEBI:6909

Drugs.com:http://www.drugs.com/metronidazole.html

PubChem Substance:46508911

ChemSpider:4029

PubChem Compound:4173

Wikipedia:Metronidazole

CiteXplore:16901452

CASRN:443-48-1

RxList:http://www.rxlist.com/cgi/generic/metron.htm

CiteXplore:11906111

National Drug Code Directory:0299-3835-45

CiteXplore:22226009

Patent:US2944061

Reaxys:611683

Wikipedia:http://en.wikipedia.org/wiki/Metronidazole

CiteXplore:18397330

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_6909 EFO SAME_URI
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http://purl.obolibrary.org/obo/CHEBI_6909 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6909 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6909 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6909 ODNAE SAME_URI
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http://purl.bioontology.org/ontology/ATC/D06BX01 ATC LOOM
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http://purl.bioontology.org/ontology/SNMI/C-52040 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372602008 SNOMEDCT LOOM
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http://purl.obolibrary.org/obo/OMIT_0009850 OMIT LOOM
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http://purl.bioontology.org/ontology/LNC/MTHU060429 LOINC LOOM
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http://purl.obolibrary.org/obo/MESH_D008795 BERO LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00692 COID LOOM
http://purl.bioontology.org/ontology/VANDF/4017836 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 BERO LOOM
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http://purl.obolibrary.org/obo/CHEBI_6909 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 ODNAE LOOM
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http://purl.bioontology.org/ontology/RXNORM/6922 RXNORM LOOM
http://www.limics.fr/ontologies/ontoparonmed#Flagyl ONTOPARON LOOM
http://purl.bioontology.org/ontology/LNC/LP14997-8 LOINC LOOM
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http://stirdf.jst.go.jp/id/200907020376726100 IOBC LOOM
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http://purl.obolibrary.org/obo/XCO_0001189 XCO LOOM
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