Preferred Name |
ruxolitinib |
|
Synonyms |
C17H18N6 (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile INCB018424 ruxolitinib (3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_66919 |
|
AHFScode |
10:00 |
|
ATCCode |
L01XE18 |
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CASRN |
941678-49-5 |
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DBBrand |
jakavi jakafi |
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DBSalt |
ruxolitinib phosphate |
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DBSynonym |
incb424 incb018424 incb 18424 |
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Definition |
Ruxolitinib is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis. FDA approved on November 16, 2011. A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. |
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has pharmacological target | ||
has role | ||
InChI |
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 |
|
InChIKey |
InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N |
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inhibits | ||
is metabolised by | ||
label |
ruxolitinib |
|
may interact with |
http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/dinto_DB00582 |
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prefixIRI |
obo2:CHEBI_66919 |
|
prefLabel |
ruxolitinib |
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SMILES |
N#CC[C@H](C1CCCC1)N1C=C(C=N1)C1=C2C=CNC2=NC=N1 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 |
|
Synonym |
C17H18N6 (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile INCB018424 ruxolitinib (3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1H-pyrazol-1-yl)propanenitrile |
|
xref |
CiteXplore:22474318 Drugs.com:http://www.drugs.com/mtm/ruxolitinib.html CASRN:941678-49-5 CiteXplore:22544377 CiteXplore:22227528 CiteXplore:22375971 Patent:US2008312258 National Drug Code Directory:50881-025-60 Wikipedia:Ruxolitinib CiteXplore:21926964 CiteXplore:22422826 Reaxys:18703668 CiteXplore:22281165 CiteXplore:22718840 CiteXplore:22830345 CiteXplore:22034658 CiteXplore:21602517 RxList:http://www.rxlist.com/jakafi-drug.htm CiteXplore:21919691 Patent:US2010190981 CiteXplore:22279053 ChEBI:66919 CiteXplore:22375970 ChEMBL:1253572 Wikipedia:http://en.wikipedia.org/wiki/Ruxolitinib KEGG DRUG:D09959 CiteXplore:22399854 |
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subClassOf |