The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

losartan

Synonyms

(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol

(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol

Losartan

losartan

C22H23ClN6O

2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole

[2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol

ID

http://purl.obolibrary.org/obo/CHEBI_6541

AHFScode

24:32.08

ATCCode

C09CA01

blocks

http://purl.obolibrary.org/obo/dinto_0968

CASRN

114798-26-4

DBBrand

lortaan

lacidipine

hyzaar

cozaar

DBname

losartan

DBSalt

losartan potassium

DBSynonym

mk594

dup 89

Definition

A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0001297

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001510

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001520

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001167

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0001538

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000851

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0001461

http://purl.obolibrary.org/obo/OAE_0001057

http://purl.obolibrary.org/obo/OAE_0000327

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001106

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000613

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000789

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0001403

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000347

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000330

http://purl.obolibrary.org/obo/OAE_0001366

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350

http://purl.obolibrary.org/obo/OAE_0000304

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0968

has role

http://purl.obolibrary.org/obo/CHEBI_61016

http://purl.obolibrary.org/obo/CHEBI_38070

http://purl.obolibrary.org/obo/CHEBI_51451

http://purl.obolibrary.org/obo/CHEBI_35674

InChI

InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

InChIKey

InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_1155

http://purl.obolibrary.org/obo/dinto_1154

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_0520

is metabolised by

http://purl.obolibrary.org/obo/dinto_1891

http://purl.obolibrary.org/obo/dinto_1890

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_1889

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_0276

is substrate of

http://purl.obolibrary.org/obo/dinto_0217

is transported by

http://purl.obolibrary.org/obo/dinto_1440

label

losartan

may interact with

http://purl.obolibrary.org/obo/dinto_DB00519

http://purl.obolibrary.org/obo/dinto_DB00384

http://purl.obolibrary.org/obo/CHEBI_49662

http://purl.obolibrary.org/obo/CHEBI_50838

http://purl.obolibrary.org/obo/CHEBI_9241

http://purl.obolibrary.org/obo/CHEBI_15367

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_50861

http://purl.obolibrary.org/obo/dinto_DB00684

http://purl.obolibrary.org/obo/dinto_DB01369

http://purl.obolibrary.org/obo/dinto_DB00046

http://purl.obolibrary.org/obo/CHEBI_2639

http://purl.obolibrary.org/obo/CHEBI_27999

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/dinto_DB01345

prefixIRI

obo2:CHEBI_6541

prefLabel

losartan

SMILES

CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1

CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

Synonym

(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol

(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol

Losartan

losartan

C22H23ClN6O

2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole

[2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol

xref

PubChem Substance:46506538

Beilstein:4770867

Reaxys:4770867

Drugs Product Database (DPD):2182882

ChEBI:6541

ChEMBL:508842

RxList:http://www.rxlist.com/cgi/generic/losar.htm

Guide To Pharmacology:590

ChemSpider:3824

KEGG COMPOUND:C07072

Patent:EP253310

Patent:US5138069

DrugBank:DB00678

KEGG DRUG:D08146

CASRN:114798-26-4

Drugs.com:http://www.drugs.com/cdi/losartan.html

National Drug Code Directory:0006-0951-54

CiteXplore:15703421

Wikipedia:http://en.wikipedia.org/wiki/Losartan

PubChem Compound:3961

IUPHAR:590

PharmGKB:PA450268

Wikipedia:Losartan

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_6541 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 COVID-19 SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6541 ODNAE SAME_URI
http://purl.obolibrary.org/obo/XCO_0000161 XCO LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 CHEBI LOOM
http://purl.bioontology.org/ontology/SNMI/C-81310 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0126174 OCHV LOOM
http://purl.jp/bio/4/id/200906081834141112 IOBC LOOM
http://purl.bioontology.org/ontology/CSP/4009-0050 CRISP LOOM
http://www.drugbank.ca/drugs/DB00678 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4020913 VANDF LOOM
http://purl.obolibrary.org/obo/MESH_D019808 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373567002 SNOMEDCT LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02629 MIO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.185.475 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_6541 ODNAE LOOM
http://purl.bioontology.org/ontology/ATC/C09CA01 ATC LOOM
http://www.co-ode.org/ontologies/galen#Losartan GALEN LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66869 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D019808 MESH LOOM
http://stirdf.jst.go.jp/id/200907078307540389 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16349 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0019790 OMIT LOOM
https://go.drugbank.com/drugs/DB00678 MDM LOOM
http://purl.obolibrary.org/obo/NCIT_C66869 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.617.467 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/52175 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/52175 RXNORM LOOM
http://bmi.utah.edu/ontologies/hfontology/C0126174 HFO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019808 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016796 PMAPP-PMO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148401 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148401 OCVDAE LOOM
http://purl.bioontology.org/ontology/LNC/LP171619-2 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/bk3.. RCD LOOM
http://purl.bioontology.org/ontology/NDDF/004991 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.507 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148401 NDFRT LOOM