Preferred Name |
nebivolol |
|
Synonyms |
(1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol} dl-nebivolol 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino}ethan-1-ol nebivolol C22H25F2NO4 nebivololum |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_64022 |
|
ATCCode |
C07AB12 |
|
blocks | ||
CASRN |
99200-09-6 |
|
DBBrand |
pi-21858 nodon nebilet nebilong nebicard-5 bystolic lobivon nubeta nebipill |
|
DBname |
nebivolol |
|
DBSynonym |
nebivololum [latin] |
|
Definition |
A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure. |
|
has effect |
http://purl.obolibrary.org/obo/OAE_0000238 http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0001285 http://purl.obolibrary.org/obo/OAE_0000259 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001595 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000374 |
|
has pharmacological target | ||
has role |
http://purl.obolibrary.org/obo/CHEBI_35620 |
|
InChI |
InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2 |
|
InChIKey |
InChIKey=KOHIRBRYDXPAMZ-UHFFFAOYSA-N |
|
is metabolised by | ||
label |
nebivolol |
|
prefixIRI |
obo2:CHEBI_64022 |
|
prefLabel |
nebivolol |
|
SMILES |
OC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2 |
|
Synonym |
(1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol} dl-nebivolol 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino}ethan-1-ol nebivolol C22H25F2NO4 nebivololum |
|
xref |
DrugBank:DB04861 PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam CASRN:118457-14-0 CiteXplore:18786089 CiteXplore:20620250 PubChem Substance:99443225 Reaxys:4789059 CiteXplore:17661735 ChemSpider:64421 KEGG DRUG:D05127 CiteXplore:18078016 CiteXplore:19443516 Patent:US4654362 Wikipedia:Nebivolol RxList:http://www.rxlist.com/bystolic-tablets-drug.htm CiteXplore:18083889 National Drug Code Directory:54868-5944-0 CiteXplore:19815121 PubChem Compound:71301 Drugs.com:http://www.drugs.com/cdi/nebivolol.html PharmGKB:PA151958426 Wikipedia:http://en.wikipedia.org/wiki/Nebivolol CiteXplore:18221115 |
|
subClassOf |