The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	topiramate
Synonyms	TPM Topiramate [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate Topamax 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate tipiramate C12H21NO8S topiramato RWJ-17021 tipiramato topiramatum topiramate McN-4853
ID	http://purl.obolibrary.org/obo/CHEBI_63631
activates	http://purl.obolibrary.org/obo/dinto_2875
AHFScode	28:12.92
altId	CHEBI:9633
ATCCode	N03AX11
blocks	http://purl.obolibrary.org/obo/dinto_1555
CASRN	97240-79-4
DBBrand	topamax topamax sprinkle
DBname	topiramate
DBSynonym	tipiramate [french] topiramatum [inn-latin] topiramic acid
Definition	A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000447 http://purl.obolibrary.org/obo/OAE_0000395 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0001154 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0001167 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000900 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0001707 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000677 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0000207 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000945 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000863 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001433 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001062 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000995 http://purl.obolibrary.org/obo/OAE_0000671 http://purl.obolibrary.org/obo/OAE_0001461 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001295 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001202 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000495 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0001152 http://purl.obolibrary.org/obo/OAE_0001356 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0000800 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000701 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001170 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000500 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2875 http://purl.obolibrary.org/obo/dinto_1555 http://purl.obolibrary.org/obo/dinto_0512 http://purl.obolibrary.org/obo/dinto_1621 http://purl.obolibrary.org/obo/dinto_2679
has role	http://purl.obolibrary.org/obo/CHEBI_38633 http://purl.obolibrary.org/obo/CHEBI_35623
InChI	InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
InChIKey	InChIKey=KJADKKWYZYXHBB-XBWDGYHZSA-N
induces	http://purl.obolibrary.org/obo/dinto_0901
inhibits	http://purl.obolibrary.org/obo/dinto_0512 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_1621 http://purl.obolibrary.org/obo/dinto_2679
label	topiramate
prefixIRI	obo2:CHEBI_63631
prefLabel	topiramate
SMILES	CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 [H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2
Synonym	TPM Topiramate [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate Topamax 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate tipiramate C12H21NO8S topiramato RWJ-17021 tipiramato topiramatum topiramate McN-4853
xref	BindingDB:10887 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/top1541.shtml ChemSpider:4447672 KEGG COMPOUND:C07502 Drugs.com:http://www.drugs.com/cdi/topiramate.html RxList:http://www.rxlist.com/cgi/generic2/topiram.htm Drugs Product Database (DPD):2239908 Wikipedia:Topiramate CASRN:97240-79-4 CiteXplore:22233396 Wikipedia:http://en.wikipedia.org/wiki/Topiramate ChEMBL:466279 PubChem Substance:46508334 PharmGKB:PA451728 Reaxys:5988957 DrugBank:DB00273 National Drug Code Directory:0904-6016-04 CiteXplore:22249827 KEGG DRUG:D00537 Patent:US4513006 PubChem Compound:5284627
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_63631	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63631	EFO	LOOM
http://www.case.edu/EpilepsyOntology.owl#Topiramate	EPSO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63631	CHEBI	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148493	ODAE	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026564	PMAPP-PMO	LOOM
http://www.case.edu/EpSO.owl#Topiramate	MEPO	LOOM
http://purl.bioontology.org/ontology/MESH/D000077236	MESH	LOOM
http://purl.bioontology.org/ontology/CPT/80201	CPT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C052342	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C47764	BERO	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000670650	PDQ	LOOM
http://www.co-ode.org/ontologies/galen#Topiramate	GALEN	LOOM
http://stirdf.jst.go.jp/id/200907067012962972	IOBC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148493	NDFRT	LOOM
http://purl.bioontology.org/ontology/LNC/LP19239-0	LOINC	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClasse4ca59d1_15c3_4eef_b1be_37f5367c40ae	WWECA	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14957	OCHV	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0076829	OCHV	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass8a831dea_5158_4deb_9765_16ca32b945b8	WWECA	LOOM
https://go.drugbank.com/drugs/DB00273	MDM	LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Topiramate	FRMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63631	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63631	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63631	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63631	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_63631	ODNAE	LOOM
http://www.drugbank.ca/drugs/DB00273	FTC	LOOM
http://purl.bioontology.org/ontology/NDDF/005453	NDDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47764	NCIT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007741	LOINC	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass992ffef7_6dc2_4e64_8e62_a2ca70615e19	WWECA	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassb6ddde45_723b_4125_a3f6_c0ffc106754f	WWECA	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Topiramate	STMSO	LOOM
http://purl.bioontology.org/ontology/RCD/dnk..	RCD	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass6bbcfafd_3a1d_473d_b50f_269332b31b99	WWECA	LOOM
http://purl.bioontology.org/ontology/RXNORM/38404	RXNORM	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass42d18b2b_8c13_437e_b7c7_9d2434a3e154	WWECA	LOOM
http://purl.bioontology.org/ontology/ATC/N03AX11	ATC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386844006	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/VANDF/4021026	VANDF	LOOM
http://purl.jp/bio/4/id/200906092482607711	IOBC	LOOM