The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

pravastatin

Synonyms

pravastatin acid

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

C23H36O7

pravastatine

pravastatinum

pravastatina

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

pravastatin

ID

http://purl.obolibrary.org/obo/CHEBI_63618

altId

CHEBI:8360

Definition

A carboxylic ester resulting from the formal condensation or (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.

has role

http://purl.obolibrary.org/obo/CHEBI_35821

http://purl.obolibrary.org/obo/CHEBI_26619

http://purl.obolibrary.org/obo/CHEBI_35664

InChI

InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1

InChIKey

InChIKey=TUZYXOIXSAXUGO-PZAWKZKUSA-N

label

pravastatin

prefixIRI

obo2:CHEBI_63618

prefLabel

pravastatin

SMILES

[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC

Synonym

pravastatin acid

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

C23H36O7

pravastatine

pravastatinum

pravastatina

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

pravastatin

xref

ChEMBL:278796

KEGG COMPOUND:C01844

CiteXplore:21851379

CiteXplore:21749370

Wikipedia:Pravastatin

Reaxys:4825538

CASRN:81093-37-0

HMDB:HMDB05022

DrugBank:DB00175

KEGG DRUG:D08410

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.jp/bio/4/id/200906093225057464 IOBC LOOM
http://purl.jp/bio/4/id/200906093225057464 IOBC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#pravastatin ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148255 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00175 FTC LOOM
http://purl.bioontology.org/ontology/LNC/LP171630-9 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/C10AA03 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/003606 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4020548 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/x01R3 RCD LOOM
http://d-nb.info/gnd/4255787-2 FAST-TOPICAL LOOM
http://www.co-ode.org/ontologies/galen#Pravastatin GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.930 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907020855913870 IOBC LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.930 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0085542 ONTOAD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373566006 SNOMEDCT LOOM
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http://purl.bioontology.org/ontology/SNOMEDCT/96305006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D017035 MESH LOOM
http://www.owl-ontologies.com/OntologyXCT.owl#Pravastatin CTX LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000424450 PDQ LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 ODAE LOOM
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