The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

lamivudine
Synonyms

3'-Thia-2',3'-dideoxycytidine

Epivir

Lamivudine

4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one

4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one

(-)-2'-Deoxy-3'-thiacytidine

beta-L-2',3'-Dideoxy-3'-thiacytidine

C8H11N3O3S

beta-L-3'-Thia-2',3'-dideoxycytidine

2',3'-Dideoxy-3'-thiacytidine

(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

lamivudine

3TC
ID

http://purl.obolibrary.org/obo/CHEBI_63577
AHFScode

08:18.08.20
altId

CHEBI:6366
ATCCode

J05AF05
CASRN

134678-17-4
DBBrand

epivir-hbv

epivir

3tc

zeffix

heptovir

hepitec
DBname

lamivudine
Definition

A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0001463

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0001433

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0001057

http://purl.obolibrary.org/obo/OAE_0001190

http://purl.obolibrary.org/obo/OAE_0000286

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000525

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0001403

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0001147

http://purl.obolibrary.org/obo/OAE_0001052

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000296

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000242

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0001398

http://purl.obolibrary.org/obo/OAE_0001035

http://purl.obolibrary.org/obo/OAE_0000618

http://purl.obolibrary.org/obo/OAE_0001418

http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2873

http://purl.obolibrary.org/obo/dinto_1703

http://purl.obolibrary.org/obo/dinto_3880
has role

http://purl.obolibrary.org/obo/CHEBI_53756

http://purl.obolibrary.org/obo/CHEBI_36044

http://purl.obolibrary.org/obo/CHEBI_38234

http://purl.obolibrary.org/obo/CHEBI_64951
InChI

InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
InChIKey

InChIKey=JTEGQNOMFQHVDC-NKWVEPMBSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_1703

http://purl.obolibrary.org/obo/dinto_3880

http://purl.obolibrary.org/obo/dinto_2828
is metabolised by

http://purl.obolibrary.org/obo/dinto_1787

http://purl.obolibrary.org/obo/dinto_3052

http://purl.obolibrary.org/obo/dinto_3360

http://purl.obolibrary.org/obo/dinto_1141

http://purl.obolibrary.org/obo/dinto_1105

http://purl.obolibrary.org/obo/dinto_1139

http://purl.obolibrary.org/obo/dinto_2044

http://purl.obolibrary.org/obo/dinto_3923
is transported by

http://purl.obolibrary.org/obo/dinto_0588

http://purl.obolibrary.org/obo/dinto_1979

http://purl.obolibrary.org/obo/dinto_1972

http://purl.obolibrary.org/obo/dinto_1970

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_0300
label

lamivudine
may interact with

http://purl.obolibrary.org/obo/CHEBI_10101

http://purl.obolibrary.org/obo/CHEBI_63635

http://purl.obolibrary.org/obo/dinto_DB00684
prefixIRI

obo2:CHEBI_63577
prefLabel

lamivudine
related with

http://purl.obolibrary.org/obo/dinto_2873

http://purl.obolibrary.org/obo/dinto_0887
SMILES

Nc1ccn([C@@H]2CS[C@H](CO)O2)c(=O)n1

NC1=NC(=O)N(C=C1)[C@@H]1CS[C@H](CO)O1
Synonym

3'-Thia-2',3'-dideoxycytidine

Epivir

Lamivudine

4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one

4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one

(-)-2'-Deoxy-3'-thiacytidine

beta-L-2',3'-Dideoxy-3'-thiacytidine

C8H11N3O3S

beta-L-3'-Thia-2',3'-dideoxycytidine

2',3'-Dideoxy-3'-thiacytidine

(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

lamivudine

3TC
xref

CiteXplore:22233654

ChEBI:63577

KEGG COMPOUND:C07065

CiteXplore:22211086

CiteXplore:21851334

Wikipedia:http://en.wikipedia.org/wiki/Lamivudine

CiteXplore:22231575

BindingDB:50046287

National Drug Code Directory:0173-0742-00

CiteXplore:22028068

CiteXplore:22222724

RxList:http://www.rxlist.com/cgi/generic3/lamivudine.htm

Drugs Product Database (DPD):2239194

CASRN:134678-17-4

CiteXplore:21721935

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/com1513.shtml

PharmGKB:PA450163

CiteXplore:22098177

ChemSpider:54812

PubChem Substance:46507855

Patent:WO9117159

KEGG DRUG:D00353

Reaxys:5480511

Drugs.com:http://www.drugs.com/cdi/lamivudine.html

Wikipedia:Lamivudine

CiteXplore:22170540

PubChem Compound:60825

CiteXplore:22085635

CiteXplore:22078148

ChEMBL:133986

CiteXplore:22001270

CiteXplore:21465499

CiteXplore:22097898

DrugBank:DB00709

CiteXplore:22226087
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_63577 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63577 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63577 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63577 GSSO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63577 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63577 CHEBI LOOM
http://purl.obolibrary.org/obo/MESH_D019259 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0209738 OCHV LOOM
https://go.drugbank.com/drugs/DB00709 MDM LOOM
http://purl.obolibrary.org/obo/NCIT_C1471 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019259 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148418 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/J05AF05 ATC LOOM
http://purl.obolibrary.org/obo/DRON_00017772 ODNAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.245.500.950.500 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018390 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/OMIT_0019331 OMIT LOOM
http://purl.bioontology.org/ontology/VANDF/4020938 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D019259 MESH LOOM
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001120 HUPSON LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042593 PDQ LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1471 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/LP21312-1 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_63577 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63577 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63577 GSSO LOOM
http://purl.obolibrary.org/obo/CHEBI_63577 DRON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#21099 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.329.950.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/eiD.. RCD LOOM
http://purl.bioontology.org/ontology/CSP/4008-0058 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.500.925.500 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Lamivudine GALEN LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148418 ODAE LOOM
http://stirdf.jst.go.jp/id/200907041219120107 IOBC LOOM
http://purl.jp/bio/4/id/200906094698634040 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060537 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.245.500.950.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386897000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/005079 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/68244 RXNORM LOOM