The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

cefditoren

Synonyms

cefditoren

7beta-(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic acid

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C19H18N6O5S3

ID

http://purl.obolibrary.org/obo/CHEBI_59343

ATCCode

J01DD16

CASRN

117467-28-4

DBBrand

spectracef

meiact

DBname

cefditoren

DBSynonym

cdtr-pi

cefditoren pivoxil

cefditoren pivaloyloxymethyl ester

Definition

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

has effect

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001333

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000611

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0001707

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000811

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000492

http://purl.obolibrary.org/obo/OAE_0001434

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001275

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0001463

http://purl.obolibrary.org/obo/OAE_0000103

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001190

http://purl.obolibrary.org/obo/OAE_0001243

http://purl.obolibrary.org/obo/OAE_0000350

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001366

http://purl.obolibrary.org/obo/OAE_0000373

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1920

http://purl.obolibrary.org/obo/dinto_4015

has role

http://purl.obolibrary.org/obo/CHEBI_36047

InChI

InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1

InChIKey

InChIKey=KMIPKYQIOVAHOP-YLGJWRNMSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_1920

http://purl.obolibrary.org/obo/dinto_4015

label

cefditoren

may interact with

http://purl.obolibrary.org/obo/CHEBI_50275

http://purl.obolibrary.org/obo/CHEBI_7772

http://purl.obolibrary.org/obo/CHEBI_8768

http://purl.obolibrary.org/obo/CHEBI_6375

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/dinto_DB00585

http://purl.obolibrary.org/obo/CHEBI_4975

http://purl.obolibrary.org/obo/CHEBI_7915

http://purl.obolibrary.org/obo/CHEBI_8776

prefixIRI

obo2:CHEBI_59343

prefLabel

cefditoren

SMILES

[H][C@]12SCC(\C=C/c3scnc3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O

[H][C@]12SCC(C=C/C3=C(C)N=CS3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O

Synonym

cefditoren

7beta-(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic acid

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C19H18N6O5S3

xref

Patent:US4839650

Beilstein:8174297

DrugBank:DB01066

RxList:http://www.rxlist.com/cgi/generic/spectracef.htm

Wikipedia:http://en.wikipedia.org/wiki/Cefditoren

ChEBI:59343

PharmGKB:PA164747187

Drugs.com:http://www.drugs.com/cdi/cefditoren-pivoxil.html

KEGG DRUG:D07639

CASRN:104145-95-1

Patent:EP475610

National Drug Code Directory:10122-802-20

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/spe1677.shtml

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.obolibrary.org/obo/ARO_3000649 ARO LOOM
http://purl.bioontology.org/ontology/MESH/C073460 MESH LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 DRON SAME_URI
http://purl.bioontology.org/ontology/SNOMEDCT/708598002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016669 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP33348-1 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/009507 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/83682 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4024247 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022252 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C073460 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/J01DD16 ATC LOOM