The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

felodipine

Synonyms

3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

(+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

FELODIPINE

C18H19Cl2NO4

felodipine

3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

felodipinum

4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester

ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

felodipina

ID

http://purl.obolibrary.org/obo/CHEBI_585948

AHFScode

24:28.08

altId

CHEBI:49383

CHEBI:4996

ATCCode

C08CA02

blocks

http://purl.obolibrary.org/obo/dinto_3324

CASRN

72509-76-3

DBBrand

agon sr

hydac

splendil

modip

renedil

munobal retard

prevex

plendil

agon

perfudal

munobal

plendil retard

plendil er

flodil

plandil

felodur er

feloday

preslow

felogard

lexxel

penedil

plendil depottab

DBname

felodipine

DBSynonym

dl-felodipine

felodipina [inn-spanish]

felodipine [usan:ban:inn]

felodipinum [inn-latin]

Definition

The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

has effect

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000207

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0001105

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001126

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0001295

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1027

http://purl.obolibrary.org/obo/dinto_2965

http://purl.obolibrary.org/obo/dinto_3508

http://purl.obolibrary.org/obo/dinto_2979

http://purl.obolibrary.org/obo/dinto_2962

has role

http://purl.obolibrary.org/obo/CHEBI_38215

http://purl.obolibrary.org/obo/CHEBI_35674

http://purl.obolibrary.org/obo/CHEBI_38070

http://purl.obolibrary.org/obo/CHEBI_35620

InChI

InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChIKey

InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_1027

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2965

http://purl.obolibrary.org/obo/dinto_3508

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_2260

http://purl.obolibrary.org/obo/dinto_0428

http://purl.obolibrary.org/obo/dinto_2979

http://purl.obolibrary.org/obo/dinto_3113

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_2962

http://purl.obolibrary.org/obo/dinto_3240

is metabolised by

http://purl.obolibrary.org/obo/dinto_1956

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

label

felodipine

may interact with

http://purl.obolibrary.org/obo/CHEBI_9073

http://purl.obolibrary.org/obo/dinto_DB01346

http://purl.obolibrary.org/obo/dinto_DB00237

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/CHEBI_102166

http://purl.obolibrary.org/obo/dinto_DB00312

http://purl.obolibrary.org/obo/dinto_DB00220

http://purl.obolibrary.org/obo/CHEBI_15367

http://purl.obolibrary.org/obo/dinto_DB01341

http://purl.obolibrary.org/obo/dinto_DB00794

http://purl.obolibrary.org/obo/CHEBI_7824

http://purl.obolibrary.org/obo/CHEBI_6758

http://purl.obolibrary.org/obo/dinto_DB00976

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/dinto_DB01167

http://purl.obolibrary.org/obo/dinto_DB01369

http://purl.obolibrary.org/obo/CHEBI_63628

http://purl.obolibrary.org/obo/dinto_DB01353

http://purl.obolibrary.org/obo/dinto_DB01355

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/dinto_DB01352

http://purl.obolibrary.org/obo/CHEBI_102524

http://purl.obolibrary.org/obo/dinto_DB01354

http://purl.obolibrary.org/obo/dinto_DB00306

http://purl.obolibrary.org/obo/dinto_DB00532

http://purl.obolibrary.org/obo/dinto_DB01351

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_8069

http://purl.obolibrary.org/obo/CHEBI_102216

http://purl.obolibrary.org/obo/CHEBI_50861

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_31739

http://purl.obolibrary.org/obo/CHEBI_4888

prefixIRI

obo2:CHEBI_585948

prefLabel

felodipine

related with

http://purl.obolibrary.org/obo/dinto_0432

http://purl.obolibrary.org/obo/dinto_1941

http://purl.obolibrary.org/obo/dinto_0753

SMILES

CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC

CCOC(=O)C1=C(C)NC(C)=C(C1C1=C(Cl)C(Cl)=CC=C1)C(=O)OC

Synonym

3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

(+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

FELODIPINE

C18H19Cl2NO4

felodipine

3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

felodipinum

4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester

ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

felodipina

xref

Reaxys:4331472

PubChem Substance:46506968

National Drug Code Directory:0378-5011-01

Wikipedia:Felodipine

CASRN:72509-76-3

ChEMBL:18457386

Guide To Pharmacology:4190

PharmGKB:PA449591

BindingDB:50017710

PubChem Compound:3333

Drugs Product Database (DPD):2222000

DrugBank:DB01023

PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam

PDBeChem:225

ChemSpider:3216

ChEMBL:505365

Patent:EP7293

RxList:http://www.rxlist.com/cgi/generic2/felo.htm

KEGG DRUG:D00319

Wikipedia:http://en.wikipedia.org/wiki/Felodipine

ChEBI:585948

Drugs.com:http://www.drugs.com/cdi/felodipine.html

Patent:US4264611

IUPHAR:4190

NIST Chemistry WebBook:72509-76-3

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29046 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29046 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148116 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0015772 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Felodipine GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4945 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386863007 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148116 OCVDAE LOOM
http://purl.bioontology.org/ontology/UATC/C08CA02 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 CHEBI SAME_URI
http://www.drugbank.ca/drugs/DB01023 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/003602 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4020159 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/blc.. RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/4316 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.203.250 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015736 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0015772 HFO LOOM
http://purl.jp/bio/4/id/200906048500995334 IOBC LOOM
http://stirdf.jst.go.jp/id/200907041125307092 IOBC LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#felodipine SDO LOOM
http://purl.bioontology.org/ontology/MESH/D015736 MESH LOOM