The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	glyburide
Synonyms	glibenclamidum 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea Glynase 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea Diabeta Glyburide 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide 5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide glibenclamida C23H28ClN3O5S 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide glibenclamide Micronase
ID	http://purl.obolibrary.org/obo/CHEBI_5441
AHFScode	68:20.20
ATCCode	A10BB01
blocks	http://purl.obolibrary.org/obo/dinto_0341
CASRN	10238-21-8
DBBrand	glibenbeta dia-basan glibenclamid basics bastiverit normoglucon adiab glycolande tiabet glitisol orabetic prestab gen-glybe glucomid malix glibenclamid genericon glibenil suraben glibenclamid riker m. benclamin gbn 5 lisaglucon glucohexal glibenclamid-cophar gluben lederglib diabiphage glynase euglucon gliboral glimide glycomin glibil betanase dibelet glibenclamid heumann daonil micronase gliben-puren n glidiabet gewaglucon betanese 5 glybenclamide glibenclamid fabra glybenzcyclamide glyben diabeta glibetic glimel glibadone gliban glibenclamid-ratiopharm glamide euglucan maninil glicem glibesyn glibet abbenclamide pira glucoven prodiabet renabetic euglykon glucolon glibenclamid al gliben norglicem 5 euclamin cytagon debtan hexaglucon libanil gilemal nadib glubate semi-daonil glisulin glucobene calabren euglucon 5 novo-glyburide praeciglucon sugril duraglucon med-glionil azuglucon yuglucon neogluconin melix gluco-tablimen glimidstata glucoremed humedia glibens miglucan
DBname	glyburide
DBSynonym	glibenclamidum [inn-latin] glibenclamida [inn-spanish] apo-glibenclamide glibenclamide
Definition	An urea that has formula C23H28ClN3O5S.
has effect	http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0001295 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2142
has role	http://purl.obolibrary.org/obo/CHEBI_38070 http://purl.obolibrary.org/obo/CHEBI_35526
InChI	InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
InChIKey	InChIKey=ZNNLBTZKUZBEKO-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0588 http://purl.obolibrary.org/obo/dinto_1977 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_4065 http://purl.obolibrary.org/obo/dinto_2004 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_2820 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_3338 http://purl.obolibrary.org/obo/dinto_0520 http://purl.obolibrary.org/obo/dinto_3643
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901
is transported by	http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1322
label	glyburide
may interact with	http://purl.obolibrary.org/obo/CHEBI_8214 http://purl.obolibrary.org/obo/dinto_DB01401 http://purl.obolibrary.org/obo/dinto_DB01399 http://purl.obolibrary.org/obo/CHEBI_3437 http://purl.obolibrary.org/obo/dinto_DB01296 http://purl.obolibrary.org/obo/CHEBI_8499 http://purl.obolibrary.org/obo/dinto_DB01397 http://purl.obolibrary.org/obo/dinto_DB01294 http://purl.obolibrary.org/obo/CHEBI_4856 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_15365 http://purl.obolibrary.org/obo/CHEBI_3750 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/CHEBI_3127 http://purl.obolibrary.org/obo/dinto_DB00373 http://purl.obolibrary.org/obo/CHEBI_238698 http://purl.obolibrary.org/obo/CHEBI_17698 http://purl.obolibrary.org/obo/CHEBI_3441 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/CHEBI_2904 http://purl.obolibrary.org/obo/dinto_DB01359 http://purl.obolibrary.org/obo/CHEBI_6904 http://purl.obolibrary.org/obo/CHEBI_48574 http://purl.obolibrary.org/obo/dinto_DB00052 http://purl.obolibrary.org/obo/CHEBI_2379 http://purl.obolibrary.org/obo/CHEBI_3082 http://purl.obolibrary.org/obo/dinto_DB01580 http://purl.obolibrary.org/obo/CHEBI_7444 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_51450 http://purl.obolibrary.org/obo/CHEBI_4495 http://purl.obolibrary.org/obo/CHEBI_6343 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_258351 http://purl.obolibrary.org/obo/dinto_DB01398
modulates	http://purl.obolibrary.org/obo/dinto_2142 http://purl.obolibrary.org/obo/dinto_0156 http://purl.obolibrary.org/obo/dinto_3464
prefixIRI	obo2:CHEBI_5441
prefLabel	glyburide
related with	http://purl.obolibrary.org/obo/dinto_0217
SMILES	COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Synonym	glibenclamidum 1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea Glynase 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea Diabeta Glyburide 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide 5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide glibenclamida C23H28ClN3O5S 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide glibenclamide Micronase
xref	ChemSpider:3368 Wikipedia:http://en.wikipedia.org/wiki/Glibenclamide National Drug Code Directory:0378-1113-01 Beilstein:2230085 CASRN:10238-21-8 Drugs Product Database (DPD):2248008 RxList:http://www.rxlist.com/cgi/generic/glybur.htm ChEMBL:105582 Guide To Pharmacology:2414 PharmGKB:PA449782 Patent:NL6603398 KEGG COMPOUND:C07022 Wikipedia:Glyburide PubChem Substance:46509154 Patent:US3454635 Patent:NL6610580 DrugBank:DB01016 IUPHAR:2414 KEGG DRUG:D00336 ChEBI:5441 PubChem Compound:3488
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_5441	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5441	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	CHEBI	LOOM
http://purl.bioontology.org/ontology/MESH/D005905	MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D005905	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/LP14720-4	LOINC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146417	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/384978002	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	DRON	LOOM
http://purl.obolibrary.org/obo/NCIT_C29076	BERO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-A2440	SNMI	LOOM
http://www.drugbank.ca/drugs/DB01016	FTC	LOOM
http://purl.obolibrary.org/obo/OMIT_0007100	OMIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000772960	PDQ	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#glyburide	SDO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU062932	LOINC	LOOM
http://purl.bioontology.org/ontology/CSP/2841-5600	CRISP	LOOM
http://purl.bioontology.org/ontology/VANDF/4018078	VANDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29076	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0017628	OCHV	LOOM
http://purl.bioontology.org/ontology/NDDF/000912	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.828.575	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/4815	RXNORM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5521	OCHV	LOOM
https://go.drugbank.com/drugs/DB01016	MDM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.795.575	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017437	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D005905	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_5441	EFO	LOOM