The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

bortezomib
Synonyms

N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

C19H25BN4O4

N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE

[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid

Velcade

[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid

PS 341

bortezomib

PS-341
ID

http://purl.obolibrary.org/obo/CHEBI_52717
AHFScode

10:00.00
altId

CHEBI:41143
ATCCode

L01XX32
blocks

http://purl.obolibrary.org/obo/dinto_2938

http://purl.obolibrary.org/obo/dinto_3068

http://purl.obolibrary.org/obo/dinto_3066
CASRN

179324-69-7
DBBrand

velcade
DBname

bortezomib
Definition

L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0001297

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000424

http://purl.obolibrary.org/obo/OAE_0001059

http://purl.obolibrary.org/obo/OAE_0000599

http://purl.obolibrary.org/obo/OAE_0000901

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000259

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0001361

http://purl.obolibrary.org/obo/OAE_0000573

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0001505

http://purl.obolibrary.org/obo/OAE_0000817

http://purl.obolibrary.org/obo/OAE_0001154

http://purl.obolibrary.org/obo/OAE_0001098

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001273

http://purl.obolibrary.org/obo/OAE_0000882

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0001428

http://purl.obolibrary.org/obo/OAE_0000492

http://purl.obolibrary.org/obo/OAE_0000617

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0001744

http://purl.obolibrary.org/obo/OAE_0001387

http://purl.obolibrary.org/obo/OAE_0000267

http://purl.obolibrary.org/obo/OAE_0000650

http://purl.obolibrary.org/obo/OAE_0000301

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001286

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0001431

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0000791

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0000801

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000577

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001013

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0001405

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001415

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0001370

http://purl.obolibrary.org/obo/OAE_0001069

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0001288

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0001485

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000539

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000861

http://purl.obolibrary.org/obo/OAE_0001055

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0001042

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0001357

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001340

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0001062

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000851

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000943

http://purl.obolibrary.org/obo/OAE_0000938

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0000995

http://purl.obolibrary.org/obo/OAE_0001003

http://purl.obolibrary.org/obo/OAE_0000434

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0001243

http://purl.obolibrary.org/obo/OAE_0001068

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000494

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000666

http://purl.obolibrary.org/obo/OAE_0001126

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000341

http://purl.obolibrary.org/obo/OAE_0000674

http://purl.obolibrary.org/obo/OAE_0001281

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000438

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0001343

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0001145

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0001429

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0001209

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000194

http://purl.obolibrary.org/obo/OAE_0001336

http://purl.obolibrary.org/obo/OAE_0001356

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0001205

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000185

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0001305

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000336

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000347

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001128

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000514

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000167

http://purl.obolibrary.org/obo/OAE_0000296

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0001166

http://purl.obolibrary.org/obo/OAE_0000346

http://purl.obolibrary.org/obo/OAE_0000242

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000466

http://purl.obolibrary.org/obo/OAE_0000916

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000260

http://purl.obolibrary.org/obo/OAE_0000618

http://purl.obolibrary.org/obo/OAE_0000456

http://purl.obolibrary.org/obo/OAE_0000890

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0001044

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0001298

http://purl.obolibrary.org/obo/OAE_0000811

http://purl.obolibrary.org/obo/OAE_0000345
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2938

http://purl.obolibrary.org/obo/dinto_3068

http://purl.obolibrary.org/obo/dinto_3066

http://purl.obolibrary.org/obo/dinto_0139

http://purl.obolibrary.org/obo/dinto_0153
has role

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_37670

http://purl.obolibrary.org/obo/CHEBI_52726
InChI

InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChIKey

InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_1971

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0269

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_0139

http://purl.obolibrary.org/obo/dinto_0153
is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0938
label

bortezomib
may interact with

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_9588

http://purl.obolibrary.org/obo/CHEBI_37941

http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI

obo2:CHEBI_52717
prefLabel

bortezomib
SMILES

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O

CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=CN=CC=N1)B(O)O
Synonym

N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

C19H25BN4O4

N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE

[(1R)-3-methyl-1-[(2S)-3-phenyl-2-(pyrazin-2-ylformamido)propanamido]butyl]boronic acid

Velcade

[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid

PS 341

bortezomib

PS-341
xref

PDBeChem:BO2

ChEMBL:287372

CiteXplore:21504411

CiteXplore:21865767

RxList:http://www.rxlist.com/cgi/generic3/velcade.htm

DrugBank:DB00188

ChEBI:52717

Reaxys:8723817

CiteXplore:18484921

National Drug Code Directory:63020-049-01

KEGG DRUG:D03150

Wikipedia:http://en.wikipedia.org/wiki/Bortezomib

PharmGKB:PA10252

Wikipedia:Bortezomib

Drugs Product Database (DPD):2262452

CASRN:179324-69-7

CiteXplore:18980173

Drugs.com:http://www.drugs.com/cdi/bortezomib.html
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_52717 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 FYPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 HOIP SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 COVID-19 SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_52717 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 CHEBI LOOM
http://purl.bioontology.org/ontology/ATC/L01XG01 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148811 NDFRT LOOM
http://purl.obolibrary.org/obo/OMIT_0001395 OMIT LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_52717 NIFSTD LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043560 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C1176309 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015148 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/DRON_00018683 ODNAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#55829 OCHV LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148811 ODAE LOOM
http://purl.bioontology.org/ontology/VANDF/4021393 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C1851 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D000069286 MESH LOOM
http://purl.obolibrary.org/obo/MESH_D000069286 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/407097007 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1851 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/358258 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C400082 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00188 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/009985 NDDF LOOM
http://www.drugbank.ca/drugs/DB00188 FTC LOOM