The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

fosinopril

Synonyms

(2S,4S)-4-cyclohexyl-1-(2-{[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylic acid

(S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

(4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline

(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid

Fosinopril

fosinopril

(2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

C30H46NO7P

ID

http://purl.obolibrary.org/obo/CHEBI_5163

AHFScode

24:32.04

altId

CHEBI:288733

CHEBI:159901

ATCCode

C09AA09

CASRN

98048-97-6

DBBrand

monopril

staril

acecor

DBname

fosinopril

DBSynonym

fosinopril sodium

Definition

A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000497

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000236

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001045

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0001167

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0001431

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001064

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0001051

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000454

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0001275

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0000312

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0001147

http://purl.obolibrary.org/obo/OAE_0001465

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000296

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001035

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2130

has role

http://purl.obolibrary.org/obo/CHEBI_35674

http://purl.obolibrary.org/obo/CHEBI_35457

http://purl.obolibrary.org/obo/CHEBI_50266

InChI

InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30?,39?/m1/s1

InChIKey

InChIKey=BIDNLKIUORFRQP-FKDWWROVSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2130

is transported by

http://purl.obolibrary.org/obo/dinto_4065

http://purl.obolibrary.org/obo/dinto_2004

label

fosinopril

may interact with

http://purl.obolibrary.org/obo/dinto_DB00384

http://purl.obolibrary.org/obo/CHEBI_50838

http://purl.obolibrary.org/obo/CHEBI_9241

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_50861

http://purl.obolibrary.org/obo/dinto_DB00684

http://purl.obolibrary.org/obo/CHEBI_63629

http://purl.obolibrary.org/obo/CHEBI_2639

http://purl.obolibrary.org/obo/CHEBI_68564

http://purl.obolibrary.org/obo/CHEBI_68845

http://purl.obolibrary.org/obo/dinto_DB01345

prefixIRI

obo2:CHEBI_5163

prefLabel

fosinopril

SMILES

[H][C@]1(C[C@H](N(C1)C(=O)CP(=O)(CCCCc1ccccc1)OC(OC(=O)CC)C(C)C)C(O)=O)C1CCCCC1

CCC(=O)OC(OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N1C[C@@H](C[C@H]1C(O)=O)C1CCCCC1)C(C)C

Synonym

(2S,4S)-4-cyclohexyl-1-(2-{[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylic acid

(S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

(4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline

(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid

Fosinopril

fosinopril

(2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid

C30H46NO7P

xref

PubChem Compound:55891

CiteXplore:9195116

PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam

Drugs Product Database (DPD):2262428

Beilstein:8176492

KEGG DRUG:D07992

Patent:US4337201

PharmGKB:PA449710

Wikipedia:http://en.wikipedia.org/wiki/Fosinopril

Patent:US2010297711

PubChem Substance:46506495

KEGG COMPOUND:C07016

Drugs.com:http://www.drugs.com/cdi/fosinopril.html

CASRN:98048-97-6

ChEBI:5163

National Drug Code Directory:62037-935-90

ChemSpider:50469

RxList:http://www.rxlist.com/cgi/generic/fosinop.htm

DrugBank:DB00492

CiteXplore:18209565

CiteXplore:8285178

CiteXplore:11937741

CiteXplore:22729889

Patent:EP2264039

Patent:CN101367839

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.obolibrary.org/obo/CHEBI_5163 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5163 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5163 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5163 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5163 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5163 CHEBI SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65761 NCIT LOOM
http://bmi.utah.edu/ontologies/hfontology/C0118168 HFO LOOM
http://purl.obolibrary.org/obo/MESH_D017328 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0118168 OCHV LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#fosinopril SDO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.629.500 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017315 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP171400-7 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0017704 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/50166 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/50166 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017328 RH-MESH LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02622 MIO LOOM
http://purl.obolibrary.org/obo/NCIT_C65761 BERO LOOM
https://go.drugbank.com/drugs/DB00492 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_5163 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5163 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_5163 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5163 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5163 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5163 CHEBI LOOM
http://scai.fraunhofer.de/AlzheimerOntology#fosinopril ADO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372510000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/004501 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.125.072.401.623.374 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4020531 VANDF LOOM
http://www.co-ode.org/ontologies/galen#Fosinopril GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148247 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16283 OCHV LOOM
http://www.drugbank.ca/drugs/DB00492 FTC LOOM
http://purl.jp/bio/4/id/200906052686343100 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/C09AA09 ATC LOOM
http://purl.bioontology.org/ontology/RCD/x01Qf RCD LOOM
http://purl.bioontology.org/ontology/MESH/D017328 MESH LOOM
http://stirdf.jst.go.jp/id/200907049117130737 IOBC LOOM