The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

indometacin

Synonyms

C19H16ClNO4

{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid

1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid

indometacina

indometacinum

indometacine

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid

Indocin

indometacin

Indomethacin

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid

Aconip

ID

http://purl.obolibrary.org/obo/CHEBI_49662

AHFScode

28:08.04.92

altId

CHEBI:5918

CHEBI:49660

ATCCode

M01AB01

C01EB03

CASRN

53-86-1

DBBrand

novo-methacin

metartril

indorektal

indocid sr

reumacide

indolar sr

indo-tablinen

indameth

mobilan

elmetacin

inflazon

idomethine

confortid

infrocin

indomee

chrono-indocid

metindol

durametacin

inacid

indo-spray

indoxen

indo-rectolmin

hicin

indocin sr

apo-indomethacin

indoptol

indoptic

indomod

flexin continus

indomecol

chrono-indicid

rhemacin la

artrivia

indocid

novomethacin

artracin

chibro-amuno

indaflex

indomed

indo-phlogont

metacen

amuno

indacin

dolovin

sadoreum

indocid pda

arthrexin

rheumacin la

indomo

vonum

indocin i.v.

indocin i.v

dolcidium

artrinovo

liometacen

bonidon

lausit

mikametan

tannex

bonidin

indo-lemmon

miametan

nu-indo

indmethacine

dolcidium pl

indomethegan

bonidon gel

indocin

inteban sp

methazine

catlep

imbrilon

DBname

indomethacin

DBSynonym

indomethacinum

indometacine

indomethine

indometacyna

indometicina

indomethancin

imn

indomethazine

indomethacine

Definition

A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

has effect

http://purl.obolibrary.org/obo/OAE_0000599

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0001057

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000573

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0001068

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0001449

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001209

http://purl.obolibrary.org/obo/OAE_0000913

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001014

http://purl.obolibrary.org/obo/OAE_0000480

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000752

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0001360

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000687

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000917

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000526

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000882

http://purl.obolibrary.org/obo/OAE_0001144

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001343

http://purl.obolibrary.org/obo/OAE_0001308

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_2116

http://purl.obolibrary.org/obo/dinto_0212

has role

http://purl.obolibrary.org/obo/CHEBI_35480

http://purl.obolibrary.org/obo/CHEBI_35544

http://purl.obolibrary.org/obo/CHEBI_35475

InChI

InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChIKey

InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_0300

http://purl.obolibrary.org/obo/dinto_2828

http://purl.obolibrary.org/obo/dinto_1993

http://purl.obolibrary.org/obo/dinto_2116

http://purl.obolibrary.org/obo/dinto_1987

http://purl.obolibrary.org/obo/dinto_0424

http://purl.obolibrary.org/obo/dinto_2678

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_0588

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_4301

http://purl.obolibrary.org/obo/dinto_0212

http://purl.obolibrary.org/obo/dinto_0938

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_1975

http://purl.obolibrary.org/obo/dinto_1810

http://purl.obolibrary.org/obo/dinto_1890

is metabolised by

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_0265

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_0470

http://purl.obolibrary.org/obo/dinto_1890

is transported by

http://purl.obolibrary.org/obo/dinto_1974

http://purl.obolibrary.org/obo/dinto_1977

http://purl.obolibrary.org/obo/dinto_1987

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_1440

label

indometacin

prefixIRI

obo2:CHEBI_49662

prefLabel

indometacin

related with

http://purl.obolibrary.org/obo/dinto_0217

http://purl.obolibrary.org/obo/dinto_2153

http://purl.obolibrary.org/obo/dinto_0423

SMILES

COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1

COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O

Synonym

C19H16ClNO4

{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid

1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid

indometacina

indometacinum

indometacine

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid

Indocin

indometacin

Indomethacin

[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid

Aconip

xref

ChEMBL:100173

National Drug Code Directory:42211-101-11

MetaCyc:CPD-10545

RxList:http://www.rxlist.com/cgi/generic/indometh.htm

Drugs Product Database (DPD):2143372

Beilstein:497341

Wikipedia:Indometacin

Drugs.com:http://www.drugs.com/cdi/indomethacin.html

CiteXplore:6039425

Reaxys:497341

CASRN:53-86-1

IUPHAR:1909

Gmelin:1446006

CiteXplore:22931205

PDBeChem:IMN

CiteXplore:5952296

PubChem Substance:46508291

ChemSpider:3584

Patent:BE379378

DrugBank:DB00328

Wikipedia:http://en.wikipedia.org/wiki/Indomethacin

Guide To Pharmacology:1909

Patent:US3161654

CiteXplore:23992308

ChEBI:5918

BindingDB:17638

NIST Chemistry WebBook:53-86-1

PharmGKB:PA449982

KEGG DRUG:D00141

KEGG COMPOUND:C01926

PubChem Compound:3715

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://d-nb.info/gnd/4161580-3 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/UATC/C01EB03 ATC LOOM
http://purl.bioontology.org/ontology/UATC/M01AB01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/S01BC01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/M02AA23 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 ODNAE SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_49662 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 NIFSTD SAME_URI