The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

desmopressin

Synonyms

1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide

(2S)-2-{[(2S)-1-{[(4R,7S,10S,13S,16S)-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}pyrrolidin-2-yl]formamido}-5-carbamimidamido-N-(carbamoylmethyl)pentanamide

1-deamino-8-D-arginine vasopressin

C46H64N14O12S2

desmopressinum

desmopressin

DDAVP

1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin

desmopressine

desmopresina

1-desamino-8-D-arginine vasopressin

ID

http://purl.obolibrary.org/obo/CHEBI_4450

activates

http://purl.obolibrary.org/obo/dinto_1169

AHFScode

68:28.00

ATCCode

H01BA02

CASRN

16679-58-6

DBBrand

stimate

adiuretin

concentraid

minirin

ddavp

DBname

desmopressin

DBSalt

desmopressin acetate

DBSynonym

desmopressine [inn-french]

desmopressinum [inn-latin]

desmopresina [inn-spanish]

1-desamino-8-d-arginine vasopressin

Definition

A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function.

has effect

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000185

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000373

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1169

http://purl.obolibrary.org/obo/dinto_2838

http://purl.obolibrary.org/obo/dinto_2767

has role

http://purl.obolibrary.org/obo/CHEBI_33295

http://purl.obolibrary.org/obo/CHEBI_35846

http://purl.obolibrary.org/obo/CHEBI_59727

InChI

InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29-,30-,31-,32-,33-,34-/m0/s1

InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1

InChIKey

InChIKey=NFLWUMRGJYTJIN-NXBWRCJVSA-N

InChIKey=NFLWUMRGJYTJIN-PNIOQBSNSA-N

induces

http://purl.obolibrary.org/obo/dinto_2116

http://purl.obolibrary.org/obo/dinto_0938

label

desmopressin

prefixIRI

obo2:CHEBI_4450

prefLabel

desmopressin

related with

http://purl.obolibrary.org/obo/dinto_2838

http://purl.obolibrary.org/obo/dinto_2767

SMILES

NC(=N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O

NC(=O)CC[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O

Synonym

1-{[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-D-arginylglycinamide

(2S)-2-{[(2S)-1-{[(4R,7S,10S,13S,16S)-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}pyrrolidin-2-yl]formamido}-5-carbamimidamido-N-(carbamoylmethyl)pentanamide

1-deamino-8-D-arginine vasopressin

C46H64N14O12S2

desmopressinum

desmopressin

DDAVP

1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin

desmopressine

desmopresina

1-desamino-8-D-arginine vasopressin

xref

Wikipedia:http://en.wikipedia.org/wiki/Desmopressin

National Drug Code Directory:55566-5020-1

Drugs Product Database (DPD):2257718

KEGG COMPOUND:C06944

DrugBank:DB00035

CASRN:16679-58-6

PharmGKB:PA449237

RxList:http://www.rxlist.com/cgi/generic3/desmoprt.htm

Drugs.com:http://www.drugs.com/cdi/desmopressin.html

ChEMBL:466868

Beilstein:4651966

KEGG DRUG:D00291

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.obolibrary.org/obo/HIO_0000191 HIO LOOM
http://purl.obolibrary.org/obo/HIO_0000191 HIO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147801 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/126189002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4019709 VANDF LOOM
http://www.semanticweb.org/ontologies/2010/10/BPO.owl#desmopressin BHO LOOM
http://purl.bioontology.org/ontology/UATC/H01BA02 ATC LOOM
http://www.drugbank.ca/drugs/DB00035 FTC LOOM
http://stirdf.jst.go.jp/id/200907021677428390 IOBC LOOM
http://stirdf.jst.go.jp/id/200907021677428390 IOBC LOOM
http://stirdf.jst.go.jp/id/200907021677428390 IOBC LOOM
http://stirdf.jst.go.jp/id/200907021677428390 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/3251 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4450 CHEBI SAME_URI
http://www.co-ode.org/ontologies/galen#Desmopressin GALEN LOOM
http://purl.jp/bio/4/id/200906042339917311 IOBC LOOM
http://purl.jp/bio/4/id/200906042339917311 IOBC LOOM
http://purl.jp/bio/4/id/200906042339917311 IOBC LOOM
http://purl.jp/bio/4/id/200906042339917311 IOBC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/004784 NDDF LOOM
http://id.loc.gov/authorities/subjects/sh93001848 FAST-TOPICAL LOOM