The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

hydroxyurea

Synonyms

hydroxycarbamide

Hydroxyurea

CH4N2O2

carbamohydroxamic acid

hydroxycarbamidum

carbamoyl oxime

hydrea

carbamyl hydroxamate

Hydroxyharnstoff

N-HYDROXYUREA

carbamohydroximic acid

hydroxyurea

N-hydroxyurea

N-carbamoylhydroxylamine

Hydroxycarbamid

Hydroxycarbamide

hidroxicarbamida

oxyurea

ID

http://purl.obolibrary.org/obo/CHEBI_44423

AHFScode

10:00.00

altId

CHEBI:5816

CHEBI:44420

ATCCode

L01XX05

CASRN

127-07-1

DBBrand

litalir

droxia

onco-carbide

hydura

ureaphil

biosupressin

hydreia

hydurea

hydrea

hidrix

litaler

oxyurea

DBname

hydroxyurea

DBSynonym

hydroxycarbamide

n-hydroxyurea

carbamohydroxamic acid

hu

hydroxycarbamine

carbamoyl oxime

n-carbamoylhydroxylamine

carbamyl hydroxamate

carbamohydroximic acid

hydroxylurea

carbamohydroxyamic acid

hydroxicarbamidum

idrossicarbamide [dcit]

Definition

A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.

has effect

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000716

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000197

http://purl.obolibrary.org/obo/OAE_0000557

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0001341

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000943

http://purl.obolibrary.org/obo/OAE_0000691

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0001485

http://purl.obolibrary.org/obo/OAE_0000752

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000267

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0001397

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000687

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001145

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1599

has role

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_50846

http://purl.obolibrary.org/obo/CHEBI_50905

http://purl.obolibrary.org/obo/CHEBI_74213

http://purl.obolibrary.org/obo/CHEBI_48578

http://purl.obolibrary.org/obo/CHEBI_64911

http://purl.obolibrary.org/obo/CHEBI_59517

http://purl.obolibrary.org/obo/CHEBI_50902

http://purl.obolibrary.org/obo/CHEBI_35221

InChI

InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChIKey

InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_1599

http://purl.obolibrary.org/obo/dinto_2993

label

hydroxyurea

prefixIRI

obo2:CHEBI_44423

prefLabel

hydroxyurea

SMILES

NC(=O)NO

Synonym

hydroxycarbamide

Hydroxyurea

CH4N2O2

carbamohydroxamic acid

hydroxycarbamidum

carbamoyl oxime

hydrea

carbamyl hydroxamate

Hydroxyharnstoff

N-HYDROXYUREA

carbamohydroximic acid

hydroxyurea

N-hydroxyurea

N-carbamoylhydroxylamine

Hydroxycarbamid

Hydroxycarbamide

hidroxicarbamida

oxyurea

xref

CiteXplore:15994344

CASRN:127-07-1

CiteXplore:11391710

CiteXplore:9271088

MetaCyc:HYDROXY-UREA

ChEMBL:104730

CiteXplore:11298103

PubChem Substance:46506927

CiteXplore:23696560

CiteXplore:14988684

Wikipedia:http://en.wikipedia.org/wiki/Hydroxyurea

RxList:http://www.rxlist.com/cgi/generic2/hydroxyurea.htm

CASRN:1741548

PDBeChem:NHY

PharmGKB:PA449942

CiteXplore:23643402

CiteXplore:11365149

CiteXplore:11364534

Gmelin:130423

CiteXplore:12107454

DrugBank:DB01005

CiteXplore:22983419

Drugs.com:http://www.drugs.com/cdi/hydroxyurea.html

CiteXplore:11285159

CiteXplore:23318979

CiteXplore:16356682

ChEBI:5816

HMDB:HMDB15140

ChemSpider:3530

CiteXplore:15772364

Wikipedia:Hydroxyurea

Patent:US2705727

KEGG COMPOUND:C07044

Drugs Product Database (DPD):2247937

National Drug Code Directory:0555-0882-02

KEGG DRUG:D00341

PubChem Compound:3657

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.bioontology.org/ontology/CSP/0113-4000 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.395 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-78100 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D006918 MESH LOOM
http://www.co-ode.org/ontologies/galen#Hydroxyurea GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/002635 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006918 RH-MESH LOOM
http://purl.obolibrary.org/obo/HIV_5679 HIV LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146101 ODAE LOOM
http://www.drugbank.ca/drugs/DB01005 FTC LOOM
http://stirdf.jst.go.jp/id/200907035920979546 IOBC LOOM
http://scdontology.h3abionet.org/ontology/SCDO_0000580 SCDO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 ODNAE SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 MCO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_44423 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 NIFSTD SAME_URI
http://purl.bioontology.org/ontology/RCD/h55.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146101 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387314007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040685 PDQ LOOM
http://purl.jp/bio/4/id/200906063694062928 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017733 VANDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/5552 RXNORM LOOM
http://www.gamuts.net/entity#hydroxyurea GAMUTS LOOM