The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	carvedilol
Synonyms	[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine SKF 105517 Carvedilol carvedilol carvedilolum 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol C24H26N2O4 (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol
ID	http://purl.obolibrary.org/obo/CHEBI_3441
AHFScode	24:24.00 24:04.00
ATCCode	C07AG02
blocks	http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_0234 http://purl.obolibrary.org/obo/dinto_3504
CASRN	72956-09-3
DBBrand	coreg coreg cr
DBname	carvedilol
DBSynonym	carvedilolum [latin]
Definition	A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0001285 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000497 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000205 http://purl.obolibrary.org/obo/OAE_0001064 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0001595 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000281 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000984 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000612 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000353 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0001295 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001284 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001356 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_0234
has role	http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_37890 http://purl.obolibrary.org/obo/CHEBI_35674 http://purl.obolibrary.org/obo/CHEBI_35554 http://purl.obolibrary.org/obo/CHEBI_35530
InChI	InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
InChIKey	InChIKey=OGHNVEJMJSYVRP-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_4193 http://purl.obolibrary.org/obo/dinto_2900 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_1440
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0938
label	carvedilol
may interact with	http://purl.obolibrary.org/obo/dinto_DB01307 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_36791 http://purl.obolibrary.org/obo/CHEBI_2549 http://purl.obolibrary.org/obo/dinto_DB00839 http://purl.obolibrary.org/obo/dinto_DB00912 http://purl.obolibrary.org/obo/CHEBI_28918 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_7936 http://purl.obolibrary.org/obo/CHEBI_5147 http://purl.obolibrary.org/obo/CHEBI_5441 http://purl.obolibrary.org/obo/dinto_DB01306 http://purl.obolibrary.org/obo/CHEBI_49662 http://purl.obolibrary.org/obo/CHEBI_8249 http://purl.obolibrary.org/obo/dinto_DB01064 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/CHEBI_149226 http://purl.obolibrary.org/obo/CHEBI_584020 http://purl.obolibrary.org/obo/dinto_DB01291 http://purl.obolibrary.org/obo/dinto_DB00047 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/dinto_DB01289 http://purl.obolibrary.org/obo/dinto_DB01366 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/CHEBI_9449 http://purl.obolibrary.org/obo/CHEBI_9445 http://purl.obolibrary.org/obo/dinto_DB01067 http://purl.obolibrary.org/obo/dinto_DB00414 http://purl.obolibrary.org/obo/CHEBI_3723 http://purl.obolibrary.org/obo/CHEBI_9011 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_9123 http://purl.obolibrary.org/obo/dinto_DB00236 http://purl.obolibrary.org/obo/dinto_DB00046 http://purl.obolibrary.org/obo/CHEBI_4822 http://purl.obolibrary.org/obo/dinto_DB01382 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_46631 http://purl.obolibrary.org/obo/dinto_DB01287 http://purl.obolibrary.org/obo/CHEBI_6456 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_8364 http://purl.obolibrary.org/obo/dinto_DB00816 http://purl.obolibrary.org/obo/CHEBI_64318 http://purl.obolibrary.org/obo/CHEBI_31654 http://purl.obolibrary.org/obo/CHEBI_4562 http://purl.obolibrary.org/obo/CHEBI_5118 http://purl.obolibrary.org/obo/dinto_DB01309
prefixIRI	obo2:CHEBI_3441
prefLabel	carvedilol
related with	http://purl.obolibrary.org/obo/dinto_3611 http://purl.obolibrary.org/obo/dinto_2634 http://purl.obolibrary.org/obo/dinto_2763 http://purl.obolibrary.org/obo/dinto_0037
SMILES	COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2
Synonym	[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine SKF 105517 Carvedilol carvedilol carvedilolum 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol C24H26N2O4 (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol
xref	CASRN:72956-09-3 KEGG COMPOUND:C06875 CiteXplore:17383596 KEGG DRUG:D00255 RxList:http://www.rxlist.com/cgi/generic3/carvedilol.htm Wikipedia:http://en.wikipedia.org/wiki/Carvedilol Drugs Product Database (DPD):2252317 PharmGKB:PA448817 ChemSpider:2487 Drugs.com:http://www.drugs.com/cdi/carvedilol.html CiteXplore:18992766 PubChem Compound:2585 CiteXplore:11389884 Wikipedia:Carvedilol Guide To Pharmacology:551 Reaxys:1514452 HMDB:HMDB15267 PubChem Substance:46505146 ChEBI:3441 ChEMBL:136662 IUPHAR:551 CiteXplore:15184840 National Drug Code Directory:0228-2175-11 Beilstein:1514452 BindingDB:25759 Patent:DE2815926 DrugBank:DB01136 Patent:US4503067
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3441	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3441	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3441	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3441	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3441	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3441	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3441	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/XCO_0000707	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	CHEBI	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13683	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C28906	BERO	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02869	MIO	LOOM
https://go.drugbank.com/drugs/DB01136	MDM	LOOM
http://purl.jp/bio/4/id/200906025763457450	IOBC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28906	NCIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025519	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/20352	NLMVS	LOOM
http://purl.bioontology.org/ontology/RXNORM/20352	RXNORM	LOOM
http://purl.bioontology.org/ontology/RCD/bdl..	RCD	LOOM
http://stirdf.jst.go.jp/id/200907027569956426	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0054836	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/D000077261	MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386870007	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_3441	NIFSTD	LOOM
http://purl.bioontology.org/ontology/LNC/LP171650-7	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C043211	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4021041	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/C07AG02	ATC	LOOM
http://www.drugbank.ca/drugs/DB01136	FTC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000700417	PDQ	LOOM
http://purl.bioontology.org/ontology/NDDF/004167	NDDF	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0054836	HFO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148505	NDFRT	LOOM
http://www.co-ode.org/ontologies/galen#Carvedilol	GALEN	LOOM