loading...| Preferred Name |
pitavastatin |
|
| Synonyms |
NK-104 pitavastatine (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid pitavastatinum NK 104 C25H24FNO4 pitavastatia pitavastatin |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_32020 |
|
| AHFScode |
24:0608 |
|
| ATCCode |
C10AA08 |
|
| CASRN |
147511-69-1 |
|
| DBBrand |
livalo |
|
| DBSalt |
pitavastatin calcium |
|
| Definition |
A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise. Pitavastatin a lipid-lowering agent that belongs to the statin class of medications for treatment of dyslipidemia. It is also used for primary and secondary prevention of cardiovascular disease. FDA approved in Aug 3, 2009. |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000613 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000022 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000362 |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35664 |
|
| InChI |
InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1 |
|
| InChIKey |
InChIKey=VGYFMXBACGZSIL-MCBHFWOFSA-N |
|
| inhibits | ||
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_1890 http://purl.obolibrary.org/obo/dinto_1892 |
|
| is substrate of | ||
| is transported by |
http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1824 |
|
| label |
pitavastatin |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_5001 http://purl.obolibrary.org/obo/CHEBI_5296 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/dinto_DB01394 http://purl.obolibrary.org/obo/dinto_DB01601 http://purl.obolibrary.org/obo/CHEBI_15940 |
|
| prefixIRI |
obo2:CHEBI_32020 |
|
| prefLabel |
pitavastatin |
|
| SMILES |
O[C@H](C[C@H](O)\C=C\C1=C(N=C2C=CC=CC2=C1C1=CC=C(F)C=C1)C1CC1)CC(O)=O O[C@H](C[C@H](O)\\C=C\\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC(O)=O |
|
| Synonym |
NK-104 pitavastatine (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid pitavastatinum NK 104 C25H24FNO4 pitavastatia pitavastatin |
|
| xref |
CiteXplore:22345687 CiteXplore:23161429 CiteXplore:22679249 Wikipedia:Pitavastatin HMDB:HMDB41991 Wikipedia:http://en.wikipedia.org/wiki/Pitavastatin CASRN:147511-69-1 CiteXplore:22472908 CiteXplore:22850760 CiteXplore:22077103 ChEBI:32020 KEGG COMPOUND:C13334 PharmGKB:PA142650384 National Drug Code Directory:0002-4771-90 CiteXplore:22361916 ChEMBL:775704 CiteXplore:22149769 CiteXplore:22878405 CiteXplore:22053916 CiteXplore:22884685 Patent:EP2141155 CiteXplore:22133277 CiteXplore:22520230 CiteXplore:22268518 CiteXplore:22332608 Drugs.com:http://www.drugs.com/ppa/pitavastatin.html RxList:http://www.rxlist.com/livalo-drug.htm CiteXplore:22356292 CiteXplore:22627182 CiteXplore:22807641 Patent:US2011269962 Patent:US2012016129 CiteXplore:21884024 CiteXplore:22410289 CiteXplore:21075465 Reaxys:7257773 CiteXplore:22948417 CiteXplore:23007012 CiteXplore:21585411 |
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| subClassOf |