loading...| Preferred Name |
fluticasone propionate |
|
| Synonyms |
Fluticasone propionate Cutivate 6alpha,9-difluoro-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-11beta-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17alpha-yl propanoate C25H31F3O5S (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0?,?.0??,??]heptadeca-3,6-dien-14-yl propanoate |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_31441 |
|
| activates | ||
| AHFScode |
84:06.00 52:08.08 68:04.00 |
|
| altId |
CHEBI:63600 |
|
| ATCCode |
D07AC17 R01AD08 R03BA05 |
|
| blocks | ||
| CASRN |
80474-14-2 |
|
| DBBrand |
flonase flixonase flunase flixotide cutivate flovent hfa advair diskus flovent |
|
| DBname |
fluticasone propionate |
|
| Definition |
A trifluorinated corticosteroid that consits of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity. |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_37962 http://purl.obolibrary.org/obo/CHEBI_35472 http://purl.obolibrary.org/obo/CHEBI_50177 http://purl.obolibrary.org/obo/CHEBI_35523 |
|
| InChI |
InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 |
|
| InChIKey |
InChIKey=WMWTYOKRWGGJOA-CENSZEJFSA-N |
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2990 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2990 |
|
| label |
fluticasone propionate |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/dinto_DB00582 |
|
| prefixIRI |
obo2:CHEBI_31441 |
|
| prefLabel |
fluticasone propionate |
|
| related with | ||
| SMILES |
[H][C@@]12C[C@@H](C)[C@](OC(=O)CC)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C |
|
| Synonym |
Fluticasone propionate Cutivate 6alpha,9-difluoro-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-11beta-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17alpha-yl propanoate C25H31F3O5S (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0?,?.0??,??]heptadeca-3,6-dien-14-yl propanoate |
|
| xref |
Patent:NL8100707 Drugs Product Database (DPD):2244293 CASRN:80474-14-2 National Drug Code Directory:0462-0333-15 DrugBank:DB00588 Wikipedia:http://en.wikipedia.org/wiki/Fluticasone_propionate RxList:http://www.rxlist.com/cgi/generic2/cutivate.htm Reaxys:6944704 PharmGKB:PA449686 KEGG DRUG:D01708 Beilstein:6944704 Drugs.com:http://www.drugs.com/cdi/fluticasone-furoate-spray.html ChEMBL:501141 Patent:US4335121 Wikipedia:Fluticasone_Propionate ChEBI:31441 |
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| subClassOf |