The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	benazepril
Synonyms	Benazepril [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid C24H28N2O5 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R,R))- 2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
ID	http://purl.obolibrary.org/obo/CHEBI_3011
AHFScode	24:32.04
ATCCode	C09AA07
CASRN	86541-75-5
DBBrand	cibacene lotensin briem cibacen
DBname	benazepril
DBSynonym	benazeprilum [latin] benazepril hydrochloride benazepril hcl
Definition	A benzazepine that has formula C24H28N2O5.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001095 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2130
has role	http://purl.obolibrary.org/obo/CHEBI_35457
InChI	InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
InChIKey	InChIKey=XPCFTKFZXHTYIP-PMACEKPBSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2130
is metabolised by	http://purl.obolibrary.org/obo/dinto_3587
is transported by	http://purl.obolibrary.org/obo/dinto_4065 http://purl.obolibrary.org/obo/dinto_2004
label	benazepril
may interact with	http://purl.obolibrary.org/obo/dinto_DB00384 http://purl.obolibrary.org/obo/CHEBI_50838 http://purl.obolibrary.org/obo/CHEBI_9241 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB00684 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/CHEBI_2639 http://purl.obolibrary.org/obo/CHEBI_68564 http://purl.obolibrary.org/obo/CHEBI_68845 http://purl.obolibrary.org/obo/dinto_DB01345
prefixIRI	obo2:CHEBI_3011
prefLabel	benazepril
SMILES	CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CCC2=CC=CC=C2N(CC(O)=O)C1=O
Synonym	Benazepril [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid C24H28N2O5 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R,R))- 2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
xref	RxList:http://www.rxlist.com/cgi/generic/benaz.htm PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam ChEMBL:161706 KEGG COMPOUND:C06843 CASRN:86541-75-5 Drugs.com:http://www.drugs.com/cdi/benazepril.html PharmGKB:PA448561 ChEBI:3011 Wikipedia:http://en.wikipedia.org/wiki/Benazepril ChemSpider:4514935 Drugs Product Database (DPD):885835 DrugBank:DB00542 Wikipedia:Benazepril National Drug Code Directory:65162-751-03 PubChem Compound:5362124 PubChem Substance:46507884
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3011	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3011	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3011	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3011	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3011	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3011	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/XCO_0000525	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3011	CHEBI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148336	NDFRT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13553	OCHV	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148336	OCVDAE	LOOM
http://purl.bioontology.org/ontology/RXNORM/18867	NLMVS	LOOM
http://purl.bioontology.org/ontology/RXNORM/18867	RXNORM	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#benazepril	SDO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61645	NCIT	LOOM
http://purl.jp/bio/4/id/200906033466974503	IOBC	LOOM
http://stirdf.jst.go.jp/id/200907062229231745	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372511001	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C044946	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4020817	VANDF	LOOM
http://purl.bioontology.org/ontology/LNC/LP171387-6	LOINC	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#benazepril	ADO	LOOM
http://purl.bioontology.org/ontology/ATC/C09AA07	ATC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025477	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3011	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3011	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3011	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3011	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_3011	NIFSTD	LOOM
http://purl.bioontology.org/ontology/NDDF/003597	NDDF	LOOM
http://purl.obolibrary.org/obo/NCIT_C61645	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0053091	OCHV	LOOM
http://www.drugbank.ca/drugs/DB00542	FTC	LOOM
https://go.drugbank.com/drugs/DB00542	MDM	LOOM
http://purl.bioontology.org/ontology/MESH/C044946	MESH	LOOM