The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	baclofen
Synonyms	baclofenum beta-(Aminomethyl)-p-chlorohydrocinnamic acid C10H12ClNO2 beta-(4-Chlorophenyl)gaba (+-)-Baclofen DL-Baclofen DL-4-Amino-3-p-chlorophenylbutanoic acid baclofene baclofeno 4-Amino-3-(4-chlorophenyl)butyric acid beta-(Aminomethyl)-4-chlorobenzenepropanoic acid beta-(p-Chlorophenyl)-gamma-aminobutyric acid gamma-Amino-beta-(p-chlorophenyl)butyric acid baclofen 4-amino-3-(4-chlorophenyl)butanoic acid
ID	http://purl.obolibrary.org/obo/CHEBI_2972
activates	http://purl.obolibrary.org/obo/dinto_2126 http://purl.obolibrary.org/obo/dinto_1459
AHFScode	12:20.12
ATCCode	M03BX01
CASRN	1134-47-0
DBBrand	nu-baclofen pms-baclofen lioresal intrathecal baclon kemstro lioresal
DBname	baclofen
Definition	A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000888 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001045 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000612 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0000802 http://purl.obolibrary.org/obo/OAE_0000671 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000587 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000666 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000438 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0001305 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000592 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000513 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2126 http://purl.obolibrary.org/obo/dinto_1459
has role	http://purl.obolibrary.org/obo/CHEBI_51371 http://purl.obolibrary.org/obo/CHEBI_35488 http://purl.obolibrary.org/obo/CHEBI_51373
InChI	InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey	InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1975
label	baclofen
may interact with	http://purl.obolibrary.org/obo/dinto_DB00427
prefixIRI	obo2:CHEBI_2972
prefLabel	baclofen
SMILES	NCC(CC(O)=O)c1ccc(Cl)cc1 NCC(CC(O)=O)C1=CC=C(Cl)C=C1
Synonym	baclofenum beta-(Aminomethyl)-p-chlorohydrocinnamic acid C10H12ClNO2 beta-(4-Chlorophenyl)gaba (+-)-Baclofen DL-Baclofen DL-4-Amino-3-p-chlorophenylbutanoic acid baclofene baclofeno 4-Amino-3-(4-chlorophenyl)butyric acid beta-(Aminomethyl)-4-chlorobenzenepropanoic acid beta-(p-Chlorophenyl)-gamma-aminobutyric acid gamma-Amino-beta-(p-chlorophenyl)butyric acid baclofen 4-amino-3-(4-chlorophenyl)butanoic acid
xref	Drugs.com:http://www.drugs.com/baclofen.html PubChem Compound:2284 Wikipedia:http://en.wikipedia.org/wiki/Baclofen Beilstein:2104494 ChemSpider:2197 Guide To Pharmacology:1084 Patent:NL6407755 DrugBank:DB00181 Drugs Product Database (DPD):2242151 ChEMBL:132869 ChEBI:2972 BindingDB:24182 KEGG DRUG:D00241 IUPHAR:1084 RxList:http://www.rxlist.com/cgi/generic/baclofen.htm PharmGKB:PA448533 Wikipedia:Baclofen CASRN:1134-47-0 Patent:US3471548 National Drug Code Directory:0091-3351-01 PubChem Substance:46508181
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_2972	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_2972	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2972	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2972	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2972	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_2972	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_2972	NIFSTD	LOOM
http://purl.bioontology.org/ontology/LNC/LP17857-1	LOINC	LOOM
http://purl.obolibrary.org/obo/OMIT_0002794	OMIT	LOOM
http://purl.bioontology.org/ontology/NDDF/001677	NDDF	LOOM
http://www.drugbank.ca/drugs/DB00181	FTC	LOOM
http://purl.bioontology.org/ontology/RCD/j82..	RCD	LOOM
http://purl.obolibrary.org/obo/NCIT_C28858	BERO	LOOM
http://purl.bioontology.org/ontology/RXNORM/1292	RXNORM	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Baclofen	STMSO	LOOM
http://www.co-ode.org/ontologies/galen#Baclofen	GALEN	LOOM
http://purl.bioontology.org/ontology/SNMI/C-68780	SNMI	LOOM
http://stirdf.jst.go.jp/id/200907078162111107	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387342009	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.114.500.350.100	RH-MESH	LOOM
http://scai.fraunhofer.de/MSOntology#Baclofen	MSO	LOOM
http://purl.jp/bio/4/id/200906036602827110	IOBC	LOOM
http://purl.obolibrary.org/obo/MESH_D001418	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D001418	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001418	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28858	NCIT	LOOM
http://stirdf.jst.go.jp/id/200907011971241790	IOBC	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Baclofen	APAONTO	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000560777	PDQ	LOOM
https://go.drugbank.com/drugs/DB00181	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0004609	OCHV	LOOM
http://www.limics.fr/ontologies/ontoparonmed#Baclofene	ONTOPARON	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146719	NDFRT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1663	OCHV	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU019852	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4018392	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/M03BX01	ATC	LOOM
http://purl.jp/bio/4/id/200906068753530452	IOBC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016315	PMAPP-PMO	LOOM