The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	busulfan
Synonyms	C6H14O6S2 busulfan Mablin 4-(methanesulfonyloxy)butyl methanesulfonate butane-1,4-diyl dimethanesulfonate busulfanum Mitostan busulfano Busulfan Tetramethylene bis(methanesulfonate) Leucosulfan Misulban 1,4-Bis(methanesulfonoxy)butane Myleran 1,4-Dimethanesulfonoxybutane 1,4-Dimesyloxybutane Mielucin 1,4-Butanediol dimethanesulfonate Bisulfex Myeloleukon
ID	http://purl.obolibrary.org/obo/CHEBI_28901
AHFScode	10:00.00
altId	CHEBI:18936 CHEBI:3225
ATCCode	L01AB01
CASRN	55-98-1
DBBrand	myleran tablets leucosulfan busulfex mitostan myeleukon mileran misulban mylecytan mielosan mablin mielevcin mielucin myleran myeloleukon myelosan milecitan mitosan citosulfan
DBname	busulfan
DBSynonym	butanedioldimethanesulfonate tetramethylenester kyseliny methansulfonove sulphabutin busulphane tetramethylene dimethane sulfonate buzulfan busulphan sulfabutin
Definition	A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0001059 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000617 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000801 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0001707 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000465 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001370 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001500 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001062 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0001003 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001070 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000286 http://purl.obolibrary.org/obo/OAE_0001747 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000674 http://purl.obolibrary.org/obo/OAE_0001281 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0001742 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000405 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001298 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2873
has role	http://purl.obolibrary.org/obo/CHEBI_50905 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_67105 http://purl.obolibrary.org/obo/CHEBI_22333 http://purl.obolibrary.org/obo/CHEBI_50903
InChI	InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChIKey	InChIKey=COVZYZSDYWQREU-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_3307 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1226 http://purl.obolibrary.org/obo/dinto_1209 http://purl.obolibrary.org/obo/dinto_2897 http://purl.obolibrary.org/obo/dinto_3624
label	busulfan
may interact with	http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_6909 http://purl.obolibrary.org/obo/dinto_DB00072 http://purl.obolibrary.org/obo/CHEBI_9555 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:CHEBI_28901
prefLabel	busulfan
related with	http://purl.obolibrary.org/obo/dinto_2873
SMILES	CS(=O)(=O)OCCCCOS(C)(=O)=O
Synonym	C6H14O6S2 busulfan Mablin 4-(methanesulfonyloxy)butyl methanesulfonate butane-1,4-diyl dimethanesulfonate busulfanum Mitostan busulfano Busulfan Tetramethylene bis(methanesulfonate) Leucosulfan Misulban 1,4-Bis(methanesulfonoxy)butane Myleran 1,4-Dimethanesulfonoxybutane 1,4-Dimesyloxybutane Mielucin 1,4-Butanediol dimethanesulfonate Bisulfex Myeloleukon
xref	ChEMBL:156644 DrugBank:DB01008 National Drug Code Directory:67286-0054-2 Drugs.com:http://www.drugs.com/cdi/busulfan.html Patent:US2917432 ChEBI:28901 CiteXplore:19361744 CiteXplore:10523796 KEGG COMPOUND:C06862 CiteXplore:19611402 Reaxys:1791786 Drugs Product Database (DPD):2240602 Beilstein:1791786 PubChem Substance:46506234 PharmGKB:PA448691 KEGG DRUG:D00248 RxList:http://www.rxlist.com/cgi/generic2/busulfan.htm PubChem Compound:2478 ChemSpider:2384 CASRN:55-98-1 Wikipedia:Busulfan Wikipedia:http://en.wikipedia.org/wiki/Busulfan
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_28901	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	VDOT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	FB-CV	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	PECO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28901	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	CHEBI	LOOM
http://purl.bioontology.org/ontology/LNC/LP18783-8	LOINC	LOOM
http://www.gamuts.net/entity#busulfan	GAMUTS	LOOM
http://purl.obolibrary.org/obo/MESH_D002066	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147076	NDFRT	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	VDOT	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	FB-CV	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_28901	PECO	LOOM
http://purl.bioontology.org/ontology/CSP/2840-4511	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002066	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906012720303749	IOBC	LOOM
http://purl.bioontology.org/ontology/NDDF/002638	NDDF	LOOM
https://go.drugbank.com/drugs/DB01008	MDM	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004760	LOINC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015730	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2245	OCHV	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041947	PDQ	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.455.125.125	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387138002	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/LNC/LP416906-8	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.326.146.100.050.500.100	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0003415	OMIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C321	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/1828	RXNORM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78030	SNMI	LOOM
http://stirdf.jst.go.jp/id/200907009861821355	IOBC	LOOM
http://purl.bioontology.org/ontology/VANDF/4018773	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/L01AB01	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0006463	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C321	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D002066	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.645.600.055.050.510.100	RH-MESH	LOOM