The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	artemether
Synonyms	beta-artemether (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane artemisininelactol methyl ether artemether artemetero artemetherum 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine beta-dihydroartemisinin methyl ether dihydroartemisinin methyl ether C16H26O5 methyl-dihydroartemisinine
ID	http://purl.obolibrary.org/obo/CHEBI_195280
AHFScode	8:30.08
ATCCode	P01BE02
CASRN	71963-77-4
DBname	artemether
DBSynonym	sm-224 dihydroqinghaosu methyl ether dihydroartemisinin methyl ether
Definition	An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
has role	http://purl.obolibrary.org/obo/CHEBI_38068
InChI	InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChIKey	InChIKey=SXYIRMFQILZOAM-HVNFFKDJSA-N
induces	http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
label	artemether
may interact with	http://purl.obolibrary.org/obo/CHEBI_8212 http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/dinto_DB00556 http://purl.obolibrary.org/obo/CHEBI_7627 http://purl.obolibrary.org/obo/CHEBI_36791 http://purl.obolibrary.org/obo/dinto_DB01142 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/CHEBI_6715 http://purl.obolibrary.org/obo/CHEBI_127780 http://purl.obolibrary.org/obo/dinto_DB00243 http://purl.obolibrary.org/obo/CHEBI_3647 http://purl.obolibrary.org/obo/CHEBI_8707 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_2955 http://purl.obolibrary.org/obo/dinto_DB00344 http://purl.obolibrary.org/obo/dinto_DB00757 http://purl.obolibrary.org/obo/dinto_DB00540 http://purl.obolibrary.org/obo/CHEBI_63611 http://purl.obolibrary.org/obo/CHEBI_71253 http://purl.obolibrary.org/obo/CHEBI_8871 http://purl.obolibrary.org/obo/CHEBI_47499 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_31515 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_5613 http://purl.obolibrary.org/obo/dinto_DB04855 http://purl.obolibrary.org/obo/dinto_DB00104 http://purl.obolibrary.org/obo/CHEBI_63609 http://purl.obolibrary.org/obo/CHEBI_47780 http://purl.obolibrary.org/obo/CHEBI_50838 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/CHEBI_48538 http://purl.obolibrary.org/obo/dinto_DB06699 http://purl.obolibrary.org/obo/CHEBI_49603 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_45081 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_4717 http://purl.obolibrary.org/obo/CHEBI_5893 http://purl.obolibrary.org/obo/dinto_DB00270 http://purl.obolibrary.org/obo/dinto_DB01357 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/CHEBI_8455 http://purl.obolibrary.org/obo/CHEBI_75984 http://purl.obolibrary.org/obo/CHEBI_5121 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00308 http://purl.obolibrary.org/obo/CHEBI_31580 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_52172 http://purl.obolibrary.org/obo/CHEBI_8673 http://purl.obolibrary.org/obo/CHEBI_100246 http://purl.obolibrary.org/obo/dinto_DB06713 http://purl.obolibrary.org/obo/CHEBI_30621 http://purl.obolibrary.org/obo/CHEBI_50815 http://purl.obolibrary.org/obo/CHEBI_3638 http://purl.obolibrary.org/obo/CHEBI_49375 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_8466 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/CHEBI_3723 http://purl.obolibrary.org/obo/dinto_DB06705 http://purl.obolibrary.org/obo/CHEBI_5801 http://purl.obolibrary.org/obo/CHEBI_50841 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_6807 http://purl.obolibrary.org/obo/dinto_DB06703 http://purl.obolibrary.org/obo/CHEBI_9467 http://purl.obolibrary.org/obo/CHEBI_65173 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/CHEBI_50777 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/CHEBI_6443 http://purl.obolibrary.org/obo/CHEBI_3061 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_15854 http://purl.obolibrary.org/obo/dinto_DB01218 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_8427 http://purl.obolibrary.org/obo/CHEBI_8428 http://purl.obolibrary.org/obo/CHEBI_4453 http://purl.obolibrary.org/obo/CHEBI_71226 http://purl.obolibrary.org/obo/CHEBI_8405 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_47781 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/dinto_DB00934 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/CHEBI_4681 http://purl.obolibrary.org/obo/CHEBI_2675 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_2666 http://purl.obolibrary.org/obo/CHEBI_5118
prefixIRI	obo2:CHEBI_195280
prefLabel	artemether
SMILES	[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](OC)O[C@]1([H])O3 [H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@H](OC)[C@@H]2C)O4
Synonym	beta-artemether (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane artemisininelactol methyl ether artemether artemetero artemetherum 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine beta-dihydroartemisinin methyl ether dihydroartemisinin methyl ether C16H26O5 methyl-dihydroartemisinine
xref	ChEMBL:18243702 ChEMBL:3279208 ChEMBL:673926 PharmGKB:PA165111698 BindingDB:50022886 Wikipedia:http://en.wikipedia.org/wiki/Artemether Beilstein:6569878 Drugs.com:http://www.drugs.com/pro/coartem.html ChEMBL:17242150 DrugBank:DB06697 KEGG DRUG:D02483 ChEMBL:16033274 ChEMBL:11141088 ChEBI:195280 RxList:http://www.rxlist.com/coartem-drug.htm CASRN:71963-77-4 ChEMBL:12781185 Wikipedia:Artemether ChEMBL:17404003
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_195280	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	EUPATH	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_195280	CHEBI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C032942	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/18343	RXNORM	LOOM
http://purl.jp/bio/4/id/200906064770748237	IOBC	LOOM
http://purl.bioontology.org/ontology/NDDF/009714	NDDF	LOOM
http://stirdf.jst.go.jp/id/200907087687631186	IOBC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73001	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13523	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026684	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/MESH/D000077549	MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C73001	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0052429	OCHV	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/420578008	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/VANDF/4028721	VANDF	LOOM
https://go.drugbank.com/drugs/DB06697	MDM	LOOM
http://purl.bioontology.org/ontology/ATC/P01BE02	ATC	LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000244	IDOMAL	LOOM
http://purl.obolibrary.org/obo/CHEBI_195280	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_195280	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_195280	EUPATH	LOOM
http://purl.obolibrary.org/obo/CHEBI_195280	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_195280	DRON	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000178417	NDFRT	LOOM