The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	nicotine
Synonyms	(RS)-nicotine (R,S)-nicotine (+-)-nicotine Nicotin C10H14N2 Nikotin 3-(1-methylpyrrolidin-2-yl)pyridine
ID	http://purl.obolibrary.org/obo/CHEBI_18723
activates	http://purl.obolibrary.org/obo/dinto_0149 http://purl.obolibrary.org/obo/dinto_2188 http://purl.obolibrary.org/obo/dinto_2189 http://purl.obolibrary.org/obo/dinto_2747 http://purl.obolibrary.org/obo/dinto_1456 http://purl.obolibrary.org/obo/dinto_1454 http://purl.obolibrary.org/obo/dinto_0101 http://purl.obolibrary.org/obo/dinto_0102 http://purl.obolibrary.org/obo/dinto_0104 http://purl.obolibrary.org/obo/dinto_0724 http://purl.obolibrary.org/obo/dinto_0150
AHFScode	88:08.00 92:02.00* 24:06.92 12:92.00
ATCCode	C10AD02 A11HA01 C04AC01 N07BA01
CASRN	54-11-5
DBBrand	mach-nic nico-fume nico-dust black leaf 40 niagara p.a. dust nicoderm fumetobac nikotyna nicotine polacrilex nicoderm cq emo-nik tendust nicotin nicocide ortho n-4 dust nicotina nicotrol nicotrol inhaler black leaf commit campbell's nico-soap habitrol flux maag nicotrol ns nic-sal nicorette prostep nicorette plus ortho n-5 dust destruxol orchid spray
DBname	nicotine
DBSynonym	nicotine alkaloid l-nicotine
Definition	An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000888 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000807 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001268 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0001420 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000329 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2188 http://purl.obolibrary.org/obo/dinto_2189 http://purl.obolibrary.org/obo/dinto_1456
has role	http://purl.obolibrary.org/obo/CHEBI_50905 http://purl.obolibrary.org/obo/CHEBI_47958 http://purl.obolibrary.org/obo/CHEBI_49110 http://purl.obolibrary.org/obo/CHEBI_50846 http://purl.obolibrary.org/obo/CHEBI_35471 http://purl.obolibrary.org/obo/CHEBI_26619 http://purl.obolibrary.org/obo/CHEBI_35474 http://purl.obolibrary.org/obo/CHEBI_52290 http://purl.obolibrary.org/obo/CHEBI_50910 http://purl.obolibrary.org/obo/CHEBI_59163
InChI	InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
InChIKey	InChIKey=SNICXCGAKADSCV-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0269
inhibits	http://purl.obolibrary.org/obo/dinto_2814 http://purl.obolibrary.org/obo/dinto_1979 http://purl.obolibrary.org/obo/dinto_1972 http://purl.obolibrary.org/obo/dinto_1970 http://purl.obolibrary.org/obo/dinto_3613 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_2789 http://purl.obolibrary.org/obo/dinto_3622
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0294 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
label	nicotine
prefixIRI	obo2:CHEBI_18723
prefLabel	nicotine
SMILES	CN1CCCC1C1=CN=CC=C1 CN1CCCC1c1cccnc1
Synonym	(RS)-nicotine (R,S)-nicotine (+-)-nicotine Nicotin C10H14N2 Nikotin 3-(1-methylpyrrolidin-2-yl)pyridine
xref	CiteXplore:7896575 CiteXplore:19389046 CiteXplore:16950410 CiteXplore:11714820 CiteXplore:17167832 CiteXplore:17206646 CiteXplore:19465085 ChemSpider:917 CiteXplore:11860617 CiteXplore:18651995 CiteXplore:22529223 CiteXplore:20338106 CiteXplore:9203638 CiteXplore:21945235 Wikipedia:http://en.wikipedia.org/wiki/Nicotine ChEBI:18723 CiteXplore:22331007 CiteXplore:17498149 CiteXplore:11471991 CiteXplore:9450943 CiteXplore:14715938 CiteXplore:15960296 CiteXplore:19100331 CiteXplore:9621392 CiteXplore:22459798 CiteXplore:22792725 CiteXplore:17942810 CiteXplore:23117126 CiteXplore:22129149 CiteXplore:15707677 CiteXplore:11192937 Beilstein:82108 Drugs Product Database (DPD):2241228 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/nic1292.shtml CiteXplore:15961264 PubChem Substance:46506924 CiteXplore:19287496 RxList:http://www.rxlist.com/cgi/generic2/nicotini.htm PharmGKB:PA450626 CiteXplore:7564279 UM-BBD:c0468 CiteXplore:22930863 DrugBank:DB00184 KEGG COMPOUND:C16150 CiteXplore:23108361 CiteXplore:22448647 CiteXplore:22935730 CiteXplore:7097594 CiteXplore:21636612 CiteXplore:20528766 CiteXplore:22855884 CiteXplore:22585541 CiteXplore:15251917 National Drug Code Directory:0009-5400-01 CiteXplore:7807214 CiteXplore:12197757 CiteXplore:22573728 CiteXplore:7566693 CiteXplore:15313135 CiteXplore:12700710 CiteXplore:8764340 CiteXplore:22770225 ChEMBL:127418 CiteXplore:16496293 CiteXplore:22218403 CiteXplore:11719700 CiteXplore:15458549 CiteXplore:11801622 CiteXplore:8156919 Beilstein:82111 HMDB:HMDB14330 CiteXplore:15894687 Drugs.com:http://www.drugs.com/nicotine.html CiteXplore:10751565 CiteXplore:22377934 CiteXplore:18383130 CiteXplore:22589423 CiteXplore:21822688 CiteXplore:18311975 Reaxys:82108 CiteXplore:12965231 CiteXplore:18922921 CiteXplore:18380035 CiteXplore:15183514 CiteXplore:11682702 CiteXplore:18077004 CiteXplore:11818389 PubChem Compound:942 PDB:NCT CASRN:22083-74-5 CiteXplore:17438652 CiteXplore:8545712
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_18723	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	CHEAR	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	OBIB	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	NBO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	HHEAR	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	UPHENO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	IDOMAL	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	HINO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	IDODEN	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_18723	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/XCO_0001049	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	EFO	LOOM
http://purl.obolibrary.org/obo/XCO_0001049	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	OBA	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	CHEBI	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Nicotine	APAONTO	LOOM
http://purl.bioontology.org/ontology/RXNORM/7407	RXNORM	LOOM
http://stirdf.jst.go.jp/id/200907009488673502	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8707	OCHV	LOOM
http://purl.bioontology.org/ontology//30059	METABUS	LOOM
http://purl.bioontology.org/ontology/NDDF/001770	NDDF	LOOM
http://www.drugbank.ca/drugs/DB00184	FTC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.518	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906023852236520	IOBC	LOOM
http://purl.obolibrary.org/obo/UPa_UPC16150	UPA	LOOM
http://stirdf.jst.go.jp/id/200907081808419572	IOBC	LOOM
http://purl.jp/bio/4/id/200906099765886085	IOBC	LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0028040	MEDLINEPLUS	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003222	LOINC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C691	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009538	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C691	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	CHEAR	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	OBIB	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	NBO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	HHEAR	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	IDOMAL	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	HINO	LOOM
http://purl.obolibrary.org/obo/CHEBI_18723	IDODEN	LOOM
http://localhost/plosthes.2017-1#817	PLOSTHES	LOOM
http://purl.bioontology.org/ontology/LNC/LP16219-5	LOINC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042243	PDQ	LOOM
http://neuromorpho.org/ontologies/experimentconditionH.owl#NMOOt_206	NMOBR	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.760.570	RH-MESH	LOOM
http://doe-generated-ontology.com/OntoAD#C0028040	ONTOAD	LOOM
http://scai.fraunhofer.de/CSEO#nicotine	CSEO	LOOM
http://www.co-ode.org/ontologies/galen#Nicotine	GALEN	LOOM
http://purl.bioontology.org/ontology/MESH/D009538	MESH	LOOM
http://scai.fraunhofer.de/CSEO#Nicotine	CSEO	LOOM
http://purl.obolibrary.org/obo/MIRO_10000170	MIRO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/68540007	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0028040	OCHV	LOOM
http://stirdf.jst.go.jp/id/200907055248996985	IOBC	LOOM
http://purl.obolibrary.org/obo/MESH_D009538	BERO	LOOM
http://purl.org/metabus/30059	TESTING_BOSCO	LOOM
http://purl.org/metabus/30059	METABUS	LOOM
http://purl.obolibrary.org/obo/OMIT_0010561	OMIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018126	PMAPP-PMO	LOOM
http://scai.fraunhofer.de/CSEO#nikotine	CSEO	LOOM
https://go.drugbank.com/drugs/DB00184	MDM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-30384	SNMI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148163	NDFRT	LOOM
http://purl.bioontology.org/ontology/CSP/2511-0531	CRISP	LOOM
http://purl.jp/bio/4/id/200906066440058318	IOBC	LOOM
http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#Nicotine	PDON	LOOM
http://purl.bioontology.org/ontology/ATC/N07BA01	ATC	LOOM
http://purl.bioontology.org/ontology/VANDF/4020286	VANDF	LOOM