The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

efavirenz
Synonyms

(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE

(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Efavirenz

C14H9ClF3NO2

(S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one

(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one

(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one

6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
ID

http://purl.obolibrary.org/obo/CHEBI_119486
AHFScode

08:18.08.16
altId

CHEBI:190461

CHEBI:47396

CHEBI:4760
ATCCode

J05AG03
CASRN

154598-52-4
DBBrand

stocrin

sustiva
DBname

efavirenz
DBSynonym

efv
Definition

1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000395

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0000303

http://purl.obolibrary.org/obo/OAE_0000557

http://purl.obolibrary.org/obo/OAE_0000905

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001303

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000267

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001449

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000205

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000197

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0001033

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0001433

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001275

http://purl.obolibrary.org/obo/OAE_0000687

http://purl.obolibrary.org/obo/OAE_0001295

http://purl.obolibrary.org/obo/OAE_0000526

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000772

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001135

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000525

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0001202

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0001336

http://purl.obolibrary.org/obo/OAE_0001356

http://purl.obolibrary.org/obo/OAE_0001205

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0001052

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0000514

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0001035

http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target

http://purl.obolibrary.org/obo/dinto_1703
has role

http://purl.obolibrary.org/obo/CHEBI_53756

http://purl.obolibrary.org/obo/CHEBI_36044
InChI

InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
InChIKey

InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
induces

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0465
inhibits

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_1703

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0465
is metabolised by

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0465
label

efavirenz
may interact with

http://purl.obolibrary.org/obo/dinto_DB00683

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_49960

http://purl.obolibrary.org/obo/dinto_DB08864

http://purl.obolibrary.org/obo/CHEBI_37924

http://purl.obolibrary.org/obo/dinto_DB00224

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/CHEBI_9150

http://purl.obolibrary.org/obo/CHEBI_584020

http://purl.obolibrary.org/obo/dinto_DB06287

http://purl.obolibrary.org/obo/dinto_DB00342

http://purl.obolibrary.org/obo/CHEBI_68595

http://purl.obolibrary.org/obo/CHEBI_40303

http://purl.obolibrary.org/obo/dinto_DB01323

http://purl.obolibrary.org/obo/CHEBI_63621

http://purl.obolibrary.org/obo/CHEBI_47657

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_2611

http://purl.obolibrary.org/obo/CHEBI_3720

http://purl.obolibrary.org/obo/CHEBI_39548

http://purl.obolibrary.org/obo/CHEBI_3732

http://purl.obolibrary.org/obo/CHEBI_9622

http://purl.obolibrary.org/obo/CHEBI_6807

http://purl.obolibrary.org/obo/CHEBI_9398

http://purl.obolibrary.org/obo/CHEBI_63628

http://purl.obolibrary.org/obo/dinto_DB08866

http://purl.obolibrary.org/obo/dinto_DB00353

http://purl.obolibrary.org/obo/CHEBI_2896

http://purl.obolibrary.org/obo/dinto_DB01287

http://purl.obolibrary.org/obo/CHEBI_9674

http://purl.obolibrary.org/obo/dinto_DB06210

http://purl.obolibrary.org/obo/CHEBI_64318

http://purl.obolibrary.org/obo/dinto_DB00976

http://purl.obolibrary.org/obo/CHEBI_4562
prefixIRI

obo2:CHEBI_119486
prefLabel

efavirenz
SMILES

FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1

FC(F)(F)[C@]1(OC(=O)NC2=C1C=C(Cl)C=C2)C#CC1CC1
Synonym

(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE

(S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Efavirenz

C14H9ClF3NO2

(S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one

(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one

(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one

6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
xref

RxList:http://www.rxlist.com/cgi/generic/efaviren.htm

ChEBI:119486

National Drug Code Directory:0056-0474-92

ChEMBL:474719

KEGG DRUG:D00896

Patent:US5519021

PharmGKB:PA449441

DrugBank:DB00625

ChEMBL:10576692

KEGG COMPOUND:C08088

Wikipedia:http://en.wikipedia.org/wiki/Efavirenz

PubChem Compound:64139

ChemSpider:57715

PubChem Substance:46506827

ChEMBL:10673109

Drugs.com:http://www.drugs.com/cdi/efavirenz.html

Patent:EP582455

Drugs Product Database (DPD):2246045

PDBeChem:EFZ

BindingDB:2483

Beilstein:7387333

PDB:EFZ

CASRN:154598-52-4

Wikipedia:Efavirenz
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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http://purl.obolibrary.org/obo/CHEBI_119486 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 HOIP SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 COVID-19 SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 HUPSON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_119486 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_119486 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 HUPSON LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_119486 DRON LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29027 NCIT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000540650 PDQ LOOM
http://purl.jp/bio/4/id/200906045925420948 IOBC LOOM
http://www.co-ode.org/ontologies/galen#Efavirenz GALEN LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148587 ODAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0674428 OCHV LOOM
http://stirdf.jst.go.jp/id/200907063104639153 IOBC LOOM
https://go.drugbank.com/drugs/DB00625 MDM LOOM
http://purl.obolibrary.org/obo/DRON_00017693 ODNAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42573 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/C098320 MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026003 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387001004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/195085 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C098320 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C29027 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LP21310-5 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013845 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/5000-0023 CRISP LOOM
http://purl.bioontology.org/ontology/VANDF/4021133 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/J05AG03 ATC LOOM