The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	warfarin
Synonyms	1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone warfarine C19H16O4 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one (Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine Coumafene Warf 10 4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- Zoocoumarin 3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin warfarina 3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin warfarin warfarinum 3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
ID	http://purl.obolibrary.org/obo/CHEBI_10033
AHFScode	20:12.04.08
ATCCode	B01AA03
CASRN	81-81-2
DBBrand	sorexa plus kumader coumafen place-pax coumarins warfarine coumefene coumaphene jantoven maveran rosex rax athrombin-k coumadin brumolin zoocoumarin frass-ratron warfilone vampirinip iii athrombin dethmor tintorane warf 42 d-con warfarat marevan co-rax vampirinip ii panwarfin kumatox latka 42 prothromadin warfarin q kumadu athrombine-k warficide mar-frin solfarin coumaphen temus w warfarin plus coumadin tabs coumafene dicusat e kypfarin tox-hid sofarin dethnel
DBname	warfarin
DBSynonym	warfarin sodium
Definition	A hydroxycoumarin that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3471
has role	http://purl.obolibrary.org/obo/CHEBI_50249 http://purl.obolibrary.org/obo/CHEBI_33288 http://purl.obolibrary.org/obo/CHEBI_50390
InChI	InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
InChIKey	InChIKey=PJVWKTKQMONHTI-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_3471 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_1221
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221
label	warfarin
may interact with	http://purl.obolibrary.org/obo/CHEBI_31348 http://purl.obolibrary.org/obo/dinto_DB01401 http://purl.obolibrary.org/obo/dinto_DB00469 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_5001 http://purl.obolibrary.org/obo/CHEBI_5004 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB08814 http://purl.obolibrary.org/obo/CHEBI_7627 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_9352 http://purl.obolibrary.org/obo/dinto_DB00400 http://purl.obolibrary.org/obo/CHEBI_2948 http://purl.obolibrary.org/obo/CHEBI_5296 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_4315 http://purl.obolibrary.org/obo/CHEBI_49668 http://purl.obolibrary.org/obo/CHEBI_18332 http://purl.obolibrary.org/obo/dinto_DB00822 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/CHEBI_66876 http://purl.obolibrary.org/obo/CHEBI_50673 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_32221 http://purl.obolibrary.org/obo/CHEBI_6715 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/CHEBI_7936 http://purl.obolibrary.org/obo/CHEBI_149836 http://purl.obolibrary.org/obo/dinto_DB00984 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_4882 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/CHEBI_8497 http://purl.obolibrary.org/obo/dinto_DB00648 http://purl.obolibrary.org/obo/CHEBI_49662 http://purl.obolibrary.org/obo/CHEBI_3499 http://purl.obolibrary.org/obo/CHEBI_2955 http://purl.obolibrary.org/obo/CHEBI_4027 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_63611 http://purl.obolibrary.org/obo/CHEBI_8249 http://purl.obolibrary.org/obo/dinto_DB00806 http://purl.obolibrary.org/obo/dinto_DB01583 http://purl.obolibrary.org/obo/CHEBI_9342 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/dinto_DB04855 http://purl.obolibrary.org/obo/CHEBI_15365 http://purl.obolibrary.org/obo/CHEBI_3750 http://purl.obolibrary.org/obo/CHEBI_63609 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/CHEBI_50838 http://purl.obolibrary.org/obo/dinto_DB00894 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/CHEBI_41423 http://purl.obolibrary.org/obo/CHEBI_8776 http://purl.obolibrary.org/obo/dinto_DB01437 http://purl.obolibrary.org/obo/CHEBI_2654 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/dinto_DB01022 http://purl.obolibrary.org/obo/dinto_DB01323 http://purl.obolibrary.org/obo/CHEBI_7731 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/dinto_DB06268 http://purl.obolibrary.org/obo/dinto_DB00279 http://purl.obolibrary.org/obo/CHEBI_9332 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_7476 http://purl.obolibrary.org/obo/CHEBI_7822 http://purl.obolibrary.org/obo/CHEBI_50845 http://purl.obolibrary.org/obo/dinto_DB01357 http://purl.obolibrary.org/obo/dinto_DB06209 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/CHEBI_39669 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/dinto_DB00461 http://purl.obolibrary.org/obo/CHEBI_72014 http://purl.obolibrary.org/obo/dinto_DB04865 http://purl.obolibrary.org/obo/CHEBI_5120 http://purl.obolibrary.org/obo/dinto_DB00621 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/CHEBI_29007 http://purl.obolibrary.org/obo/CHEBI_31580 http://purl.obolibrary.org/obo/CHEBI_100147 http://purl.obolibrary.org/obo/CHEBI_8502 http://purl.obolibrary.org/obo/CHEBI_63637 http://purl.obolibrary.org/obo/CHEBI_100241 http://purl.obolibrary.org/obo/CHEBI_100246 http://purl.obolibrary.org/obo/dinto_DB01420 http://purl.obolibrary.org/obo/CHEBI_60761 http://purl.obolibrary.org/obo/dinto_DB01110 http://purl.obolibrary.org/obo/CHEBI_5130 http://purl.obolibrary.org/obo/CHEBI_5138 http://purl.obolibrary.org/obo/CHEBI_5136 http://purl.obolibrary.org/obo/CHEBI_175901 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_50815 http://purl.obolibrary.org/obo/dinto_DB00939 http://purl.obolibrary.org/obo/dinto_DB00055 http://purl.obolibrary.org/obo/CHEBI_8466 http://purl.obolibrary.org/obo/dinto_DB00848 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/CHEBI_3723 http://purl.obolibrary.org/obo/dinto_DB06705 http://purl.obolibrary.org/obo/CHEBI_50885 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_209807 http://purl.obolibrary.org/obo/CHEBI_6909 http://purl.obolibrary.org/obo/CHEBI_40279 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB00784 http://purl.obolibrary.org/obo/CHEBI_27565 http://purl.obolibrary.org/obo/CHEBI_48574 http://purl.obolibrary.org/obo/CHEBI_45367 http://purl.obolibrary.org/obo/CHEBI_4909 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/CHEBI_6339 http://purl.obolibrary.org/obo/CHEBI_102484 http://purl.obolibrary.org/obo/dinto_DB00814 http://purl.obolibrary.org/obo/dinto_DB01404 http://purl.obolibrary.org/obo/CHEBI_9588 http://purl.obolibrary.org/obo/CHEBI_27902 http://purl.obolibrary.org/obo/CHEBI_50777 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_70707 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB03585 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_7447 http://purl.obolibrary.org/obo/dinto_DB00465 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/CHEBI_37941 http://purl.obolibrary.org/obo/CHEBI_47612 http://purl.obolibrary.org/obo/CHEBI_50667 http://purl.obolibrary.org/obo/CHEBI_4511 http://purl.obolibrary.org/obo/dinto_DB00509 http://purl.obolibrary.org/obo/CHEBI_6443 http://purl.obolibrary.org/obo/CHEBI_51450 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/CHEBI_49040 http://purl.obolibrary.org/obo/CHEBI_6128 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB00624 http://purl.obolibrary.org/obo/CHEBI_73044 http://purl.obolibrary.org/obo/CHEBI_15854 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_4453 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_59602 http://purl.obolibrary.org/obo/dinto_DB01381 http://purl.obolibrary.org/obo/dinto_DB01432 http://purl.obolibrary.org/obo/CHEBI_50694 http://purl.obolibrary.org/obo/CHEBI_46345 http://purl.obolibrary.org/obo/CHEBI_9328 http://purl.obolibrary.org/obo/CHEBI_72297 http://purl.obolibrary.org/obo/CHEBI_47381 http://purl.obolibrary.org/obo/CHEBI_63613 http://purl.obolibrary.org/obo/CHEBI_15414 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/CHEBI_4392 http://purl.obolibrary.org/obo/dinto_DB00622 http://purl.obolibrary.org/obo/CHEBI_9073 http://purl.obolibrary.org/obo/dinto_DB08804 http://purl.obolibrary.org/obo/CHEBI_65349 http://purl.obolibrary.org/obo/dinto_DB01157 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/dinto_DB00951 http://purl.obolibrary.org/obo/CHEBI_46195 http://purl.obolibrary.org/obo/dinto_DB01083 http://purl.obolibrary.org/obo/CHEBI_5118 http://purl.obolibrary.org/obo/dinto_DB01398 http://purl.obolibrary.org/obo/CHEBI_6402
prefixIRI	obo2:CHEBI_10033
prefLabel	warfarin
related with	http://purl.obolibrary.org/obo/dinto_3582 http://purl.obolibrary.org/obo/dinto_0217
SMILES	CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O CC(=O)CC(C1=CC=CC=C1)C1=C(O)C2=C(OC1=O)C=CC=C2
Synonym	1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone warfarine C19H16O4 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one (Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine Coumafene Warf 10 4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- Zoocoumarin 3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin warfarina 3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin warfarin warfarinum 3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
xref	Patent:US2427578 Drugs Product Database (DPD):2244463 DrugBank:DB00682 ChEBI:10033 Wikipedia:Warfarin PharmGKB:PA451906 National Drug Code Directory:0056-0169-70 Patent:US3239529 ChEMBL:494165 BindingDB:50088240 Patent:US2765321 Patent:US2777859 Drugs.com:http://www.drugs.com/warfarin.html Beilstein:1293536 RxList:http://www.rxlist.com/cgi/generic/warfarin.htm Wikipedia:http://en.wikipedia.org/wiki/Warfarin
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_10033	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_10033	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	OBA	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	CHEBI	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02640	MIO	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e4a06e5e_bdd1_49fc_814a_47a41d12ec58	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e4a06e5e_bdd1_49fc_814a_47a41d12ec58	CVAO	LOOM
http://stirdf.jst.go.jp/id/200907082204646470	IOBC	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571352688529240169	ACVD_ONTOLOGY	LOOM
http://purl.bioontology.org/ontology/NDDF/002084	NDDF	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148057	NDFRT	LOOM
http://purl.obolibrary.org/obo/OMIT_0015688	OMIT	LOOM
http://bmi.utah.edu/ontologies/peontology/C0043031	PE	LOOM
http://purl.jp/bio/4/id/200906041207325087	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.446.520.914	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945	NCIT	LOOM
http://stirdf.jst.go.jp/id/200907035077542769	IOBC	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0043031	HFO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.830.219.446.520.914	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D014859	MESH	LOOM
http://www.co-ode.org/ontologies/galen#Warfarin	GALEN	LOOM
http://purl.obolibrary.org/obo/MESH_D014859	BERO	LOOM
http://purl.bioontology.org/ontology/CSP/0397-0420	CRISP	LOOM
http://stirdf.jst.go.jp/id/200907061659150750	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0043031	OCHV	LOOM
https://go.drugbank.com/drugs/DB00682	MDM	LOOM
http://purl.obolibrary.org/obo/NCIT_C945	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13106	OCHV	LOOM
http://purl.bioontology.org/ontology/RCD/x01O4	RCD	LOOM
http://purl.bioontology.org/ontology/RXNORM/11289	RXNORM	LOOM
http://www.drugbank.ca/drugs/DB00682	FTC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017666	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003212	LOINC	LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Warfarin	PCAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_10033	NIFSTD	LOOM
http://purl.bioontology.org/ontology/SNMI/C-A6530	SNMI	LOOM
http://purl.jp/bio/4/id/200906087586835534	IOBC	LOOM
http://purl.jp/bio/4/id/200906089236296382	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/B01AA03	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014859	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LA28654-4	LOINC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372756006	SNOMEDCT	LOOM
http://www.gamuts.net/entity#warfarin	GAMUTS	LOOM
http://purl.bioontology.org/ontology/LNC/LP16309-4	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4019972	VANDF	LOOM
http://www.genomic-cds.org/ont/genomic-cds.owl#Warfarin	GENE-CDS	LOOM