The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

norfloxacin

Synonyms

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

norfloxacino

norfloxacinum

1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

NFLX

C16H18FN3O3

norfloxacin

norfloxacine

1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure

ID

http://purl.obolibrary.org/obo/CHEBI_100246

AHFScode

08:12.18

altId

CHEBI:7629

ATCCode

J01MA06

S01AE02

CASRN

70458-96-7

DBBrand

noroxin

chibroxin

DBname

norfloxacin

Definition

A synthetic fluoroquinolone with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.

has effect

http://purl.obolibrary.org/obo/OAE_0000599

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0001101

http://purl.obolibrary.org/obo/OAE_0001322

http://purl.obolibrary.org/obo/OAE_0000356

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001105

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0001045

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0001510

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000811

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0000329

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0001336

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0001190

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000303

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000433

http://purl.obolibrary.org/obo/OAE_0000373

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0551

http://purl.obolibrary.org/obo/dinto_1028

has role

http://purl.obolibrary.org/obo/CHEBI_36047

http://purl.obolibrary.org/obo/CHEBI_59517

InChI

InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChIKey

InChIKey=OGJPXUAPXNRGGI-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2789

http://purl.obolibrary.org/obo/dinto_1956

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2496

http://purl.obolibrary.org/obo/dinto_0269

http://purl.obolibrary.org/obo/dinto_0551

http://purl.obolibrary.org/obo/dinto_2751

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_1028

label

norfloxacin

may interact with

http://purl.obolibrary.org/obo/CHEBI_28177

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/dinto_DB01373

http://purl.obolibrary.org/obo/CHEBI_195280

http://purl.obolibrary.org/obo/CHEBI_4513

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_31794

http://purl.obolibrary.org/obo/dinto_DB00382

http://purl.obolibrary.org/obo/CHEBI_45716

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/CHEBI_51364

http://purl.obolibrary.org/obo/dinto_DB01223

http://purl.obolibrary.org/obo/dinto_DB01303

http://purl.obolibrary.org/obo/dinto_DB00893

http://purl.obolibrary.org/obo/CHEBI_9635

http://purl.obolibrary.org/obo/CHEBI_4728

http://purl.obolibrary.org/obo/CHEBI_3766

http://purl.obolibrary.org/obo/CHEBI_133809

http://purl.obolibrary.org/obo/dinto_DB00258

http://purl.obolibrary.org/obo/CHEBI_127780

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/dinto_DB01623

http://purl.obolibrary.org/obo/dinto_DB00364

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/CHEBI_27732

http://purl.obolibrary.org/obo/CHEBI_9622

http://purl.obolibrary.org/obo/dinto_DB01370

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_53766

http://purl.obolibrary.org/obo/CHEBI_10119

http://purl.obolibrary.org/obo/dinto_DB01593

http://purl.obolibrary.org/obo/CHEBI_156095

http://purl.obolibrary.org/obo/dinto_DB01592

http://purl.obolibrary.org/obo/CHEBI_9398

http://purl.obolibrary.org/obo/dinto_DB01378

http://purl.obolibrary.org/obo/CHEBI_63629

prefixIRI

obo2:CHEBI_100246

prefLabel

norfloxacin

SMILES

CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1

CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCNCC1

Synonym

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid

norfloxacino

norfloxacinum

1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

NFLX

C16H18FN3O3

norfloxacin

norfloxacine

1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure

xref

KEGG COMPOUND:C06687

DrugBank:DB01059

CiteXplore:6211142

PubChem Substance:46508634

Patent:BE863429

CiteXplore:3317294

KEGG DRUG:D00210

Drugs.com:http://www.drugs.com/mtm/norfloxacin-ophthalmic.html

Patent:US4292317

CiteXplore:6224685

Drugs Product Database (DPD):2246596

BindingDB:50045000

Wikipedia:http://en.wikipedia.org/wiki/Norfloxacin

CiteXplore:6234465

PubChem Compound:4539

Gmelin:1576626

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/nor1302.shtml

Patent:DE2840910

CiteXplore:6454381

Patent:US4146719

Beilstein:567897

ChEBI:100246

CASRN:70458-96-7

National Drug Code Directory:0006-0705-68

Wikipedia:Norfloxacin

PharmGKB:PA450654

ChemSpider:4380

CiteXplore:6461606

RxList:http://www.rxlist.com/cgi/generic3/norfloxacin.htm

CiteXplore:3908074

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.obolibrary.org/obo/ARO_3000662 ARO LOOM
http://purl.bioontology.org/ontology/NDDF/002881 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/eg9.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147623 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907005654892930 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009643 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Norfloxacin GALEN LOOM
http://purl.bioontology.org/ontology/LNC/LP16156-9 LOINC LOOM
http://id.loc.gov/authorities/subjects/sh85092409 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/VANDF/4019503 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 ODNAE SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 PHIPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 GENEPIO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 MCO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_100246 DRON SAME_URI
http://purl.bioontology.org/ontology/SNOMEDCT/387271008 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906042016138690 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/S01AE02 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008461 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.835.322.374 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-55730 SNMI LOOM
http://purl.bioontology.org/ontology/UATC/J01MA06 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D009643 MESH LOOM
http://www.drugbank.ca/drugs/DB01059 FTC LOOM
http://d-nb.info/gnd/4243995-4 FAST-TOPICAL LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147623 ODAE LOOM
http://purl.bioontology.org/ontology/RXNORM/7517 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47638 NCIT LOOM