The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	norfloxacin
Synonyms	NFLX norfloxacine 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid norfloxacino 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid norfloxacinum 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid C16H18FN3O3 norfloxacin
ID	http://purl.obolibrary.org/obo/CHEBI_100246
AHFScode	08:12.18
altId	CHEBI:7629
ATCCode	J01MA06 S01AE02
CASRN	70458-96-7
DBBrand	chibroxin noroxin
DBname	norfloxacin
Definition	A synthetic fluoroquinolone with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000599 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000356 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0001045 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0001101 http://purl.obolibrary.org/obo/OAE_0001322 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000329 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0551 http://purl.obolibrary.org/obo/dinto_1028
has role	http://purl.obolibrary.org/obo/CHEBI_59517 http://purl.obolibrary.org/obo/CHEBI_36047
InChI	InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChIKey	InChIKey=OGJPXUAPXNRGGI-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0551 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_2751 http://purl.obolibrary.org/obo/dinto_2789 http://purl.obolibrary.org/obo/dinto_1028 http://purl.obolibrary.org/obo/dinto_0520
label	norfloxacin
may interact with	http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_127780 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/dinto_DB00893 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB00258 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/CHEBI_3766 http://purl.obolibrary.org/obo/CHEBI_27732 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB01593 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_9398 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/dinto_DB01592 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB01623
prefixIRI	obo2:CHEBI_100246
prefLabel	norfloxacin
SMILES	CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1 CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCNCC1
Synonym	NFLX norfloxacine 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid norfloxacino 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid norfloxacinum 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid C16H18FN3O3 norfloxacin
xref	BindingDB:50045000 CiteXplore:3908074 Wikipedia:http://en.wikipedia.org/wiki/Norfloxacin CiteXplore:6211142 Gmelin:1576626 Patent:DE2840910 Patent:US4146719 CASRN:70458-96-7 CiteXplore:3317294 ChEBI:100246 CiteXplore:6461606 KEGG COMPOUND:C06687 Patent:BE863429 Patent:US4292317 Drugs.com:http://www.drugs.com/mtm/norfloxacin-ophthalmic.html ChemSpider:4380 RxList:http://www.rxlist.com/cgi/generic3/norfloxacin.htm PharmGKB:PA450654 CiteXplore:6234465 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/nor1302.shtml PubChem Compound:4539 KEGG DRUG:D00210 Beilstein:567897 DrugBank:DB01059 CiteXplore:6454381 Wikipedia:Norfloxacin PubChem Substance:46508634 CiteXplore:6224685 National Drug Code Directory:0006-0705-68 Drugs Product Database (DPD):2246596
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_100246	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	GENEPIO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	MCO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_100246	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	CHEBI	LOOM
http://purl.bioontology.org/ontology/ATC/S01AE02	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0028365	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/D009643	MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47638	NCIT	LOOM
http://purl.obolibrary.org/obo/OMIT_0010663	OMIT	LOOM
http://purl.jp/bio/4/id/200906042016138690	IOBC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-55730	SNMI	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008461	LOINC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8772	OCHV	LOOM
http://purl.bioontology.org/ontology/LNC/LP16156-9	LOINC	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147623	ODAE	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147623	NDFRT	LOOM
http://purl.obolibrary.org/obo/MESH_D009643	BERO	LOOM
http://purl.bioontology.org/ontology/NDDF/002881	NDDF	LOOM
http://www.co-ode.org/ontologies/galen#Norfloxacin	GALEN	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	GENEPIO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	MCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_100246	ODNAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.835.322.374	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009643	RH-MESH	LOOM
http://purl.obolibrary.org/obo/ARO_3000662	ARO	LOOM
http://www.drugbank.ca/drugs/DB01059	FTC	LOOM
https://go.drugbank.com/drugs/DB01059	MDM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017911	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/7517	RXNORM	LOOM
http://purl.bioontology.org/ontology/VANDF/4019503	VANDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387271008	SNOMEDCT	LOOM
http://stirdf.jst.go.jp/id/200907005654892930	IOBC	LOOM
http://purl.obolibrary.org/obo/NCIT_C47638	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/J01MA06	ATC	LOOM
http://purl.bioontology.org/ontology/RCD/eg9..	RCD	LOOM