loading...| Preferred Name |
amyotrophic lateral sclerosis |
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| Synonyms |
Amyotrophic Lateral Sclerosis, Guam Form LOU GEHRIGS DIS Gehrigs Disease Lou Gehrig Disease Lateral Scleroses, Amyotrophic Disease, Lou-Gehrigs MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS Lou Gehrig's disease Motor neuron disease, bulbar amyotrophic lateral sclerosis Guam Form of Amyotrophic Lateral Sclerosis Gehrig Disease Motor Neuron Disease, Amyotrophic Lateral Sclerosis ALS LOU GEHRIG DIS Amyotrophic lateral sclerosis (disorder) GEHRIGS DIS ALS (Amyotrophic Lateral Sclerosis) Dementia With Amyotrophic Lateral Sclerosis AMYOTROPHIC SCLEROSIS |
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| Definitions |
An autosomal dominant inherited form of amyloidosis. A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) |
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| ID |
http://www.ebi.ac.uk/efo/EFO_0000253 |
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| comment |
An autosomal dominant inherited form of amyloidosis. A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) |
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| alternative term |
Amyotrophic Lateral Sclerosis, Guam Form LOU GEHRIGS DIS Gehrigs Disease Lou Gehrig Disease Lateral Scleroses, Amyotrophic Disease, Lou-Gehrigs MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS Lou Gehrig's disease Motor neuron disease, bulbar amyotrophic lateral sclerosis Guam Form of Amyotrophic Lateral Sclerosis Gehrig Disease Motor Neuron Disease, Amyotrophic Lateral Sclerosis ALS LOU GEHRIG DIS Amyotrophic lateral sclerosis (disorder) GEHRIGS DIS ALS (Amyotrophic Lateral Sclerosis) Dementia With Amyotrophic Lateral Sclerosis AMYOTROPHIC SCLEROSIS |
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| definition source |
GeneRIF:12694394 GeneRIF:12783432 GeneRIF:15033789 GeneRIF:15910777 GeneRIF:15313203 GeneRIF:12502789 GeneRIF:15672551 GeneRIF:12847526 GeneRIF:12446576 GeneRIF:12235108 GeneRIF:15019581 GeneRIF:14511332 GeneRIF:14985749 GeneRIF:15006704 GeneRIF:12528821 GeneRIF:12677446 GeneRIF:14642651 GeneRIF:15326253 GeneRIF:12217886 GeneRIF:15546588 GeneRIF:12641746 GeneRIF:15634772 GeneRIF:11854285 GeneRIF:11951178 GeneRIF:15184633 GeneRIF:12458194 GeneRIF:14596848 GeneRIF:12153483 GeneRIF:15978558 GeneRIF:14675609 GeneRIF:12972170 GeneRIF:12270696 ICD9:335.20 GeneRIF:15030390 GeneRIF:14676054 GeneRIF:15330338 GeneRIF:15691826 GeneRIF:12448348 GeneRIF:11991808 DOID:332 GeneRIF:12614934 GeneRIF:11943600 GeneRIF:15069187 GeneRIF:15048885 GeneRIF:14506936 GeneRIF:14597108 GeneRIF:14991384 GeneRIF:15264227 GeneRIF:12870272 GeneRIF:15652414 GeneRIF:12475980 GeneRIF:12679596 GeneRIF:15233913 SNOMEDCT:86044005 GeneRIF:15657798 GeneRIF:15037546 GeneRIF:12480087 GeneRIF:12127151 GeneRIF:15568021 GeneRIF:12230304 GeneRIF:15388334 GeneRIF:14978393 GeneRIF:13129803 GeneRIF:12843244 GeneRIF:11996514 GeneRIF:12866199 GeneRIF:13678668 GeneRIF:15623718 GeneRIF:15076751 GeneRIF:12393885 GeneRIF:12125045 GeneRIF:12770687 NIFSTD:birnlex_12566 GeneRIF:12441104 GeneRIF:15106121 GeneRIF:12437574 GeneRIF:12210393 GeneRIF:12730211 GeneRIF:15753080 GeneRIF:12875980 GeneRIF:15789135 GeneRIF:15109247 GeneRIF:12644909 GeneRIF:14734542 GeneRIF:11675877 GeneRIF:15475574 NCIt:C34373 GeneRIF:16114275 GeneRIF:15509539 GeneRIF:12442272 GeneRIF:15465081 GeneRIF:12915461 GeneRIF:15126567 GeneRIF:12138710 GeneRIF:15094483 GeneRIF:11860274 GeneRIF:15776280 MSH:D000690 GeneRIF:11854284 GeneRIF:14970233 GeneRIF:15557516 GeneRIF:15829169 GeneRIF:15657392 GeneRIF:16020530 GeneRIF:14989597 GeneRIF:12659845 GeneRIF:16005901 GeneRIF:12707786 GeneRIF:15837590 GeneRIF:15350647 GeneRIF:15488469 GeneRIF:12039658 GeneRIF:12584731 |
|
| label |
amyotrophic lateral sclerosis |
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| prefixIRI |
efo:EFO_0000253 |
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| prefLabel |
amyotrophic lateral sclerosis |
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| see also |
URI: http://www.ebi.ac.uk/cellline#amyotrophic_lateral_sclerosis |
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| term editor |
James Malone Tomasz Adamusiak |
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| subClassOf |
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