loading...| Preferred Name |
trandolapril |
|
| Synonyms |
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid RU44570 RU-44570 Odrik RU 44570 trandolaprilum trandolapril (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester Mavik Gopten |
|
| Definitions |
A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_9649 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:22247843 PMID:8515500 PMID:9770740 PMID:8515504 PMID:23784370 PMID:25802524 CAS:87679-37-6 PMID:19337528 PMID:8515501 Chemspider:4588590 Wikipedia:Trandolapril PMID:8515499 PMID:24835355 HMDB:HMDB0014660 DrugBank:DB00519 PMID:32964020 PMID:29319234 Patent:KR20080046630 PMID:33660934 PMID:25864194 KEGG:D00383 Patent:WO2006014916 Drug_Central:2712 PMID:27215243 PMID:1648489 Reaxys:8655766 PMID:26915813 PMID:8515502 PMID:3383998 PMID:34172790 |
|
| definition |
A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension. |
|
| formula |
C24H34N2O5 |
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35674 |
|
| has_exact_synonym |
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
RU44570 RU-44570 Odrik RU 44570 trandolaprilum trandolapril (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester Mavik Gopten |
|
| id |
CHEBI:9649 |
|
| in_subset | ||
| inchi |
InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1 |
|
| inchikey |
VXFJYXUZANRPDJ-WTNASJBWSA-N |
|
| label |
trandolapril |
|
| mass |
430.545 |
|
| monoisotopicmass |
430.24677 |
|
| notation |
CHEBI:9649 |
|
| prefLabel |
trandolapril |
|
| smiles |
[H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O |
|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_50995 http://purl.obolibrary.org/obo/CHEBI_140326 http://purl.obolibrary.org/obo/CHEBI_46761 http://purl.obolibrary.org/obo/CHEBI_36244 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50995 http://purl.obolibrary.org/obo/CHEBI_140326 http://purl.obolibrary.org/obo/CHEBI_46761 http://purl.obolibrary.org/obo/CHEBI_36244 |