Preferred Name

eltrombopag

Synonyms

3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid

3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid

Definitions

A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).

ID

http://purl.obolibrary.org/obo/CHEBI_85010

charge

0

database_cross_reference

PMID:25170628

Wikipedia:Eltrombopag

PMID:25700916

PMID:25400215

PMID:25063763

PMID:24433306

CAS:496775-61-2

PMID:25578417

Drug_Central:4399

definition

A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).

formula

C25H22N4O4

has role

http://purl.obolibrary.org/obo/CHEBI_85012

http://purl.obolibrary.org/obo/CHEBI_35703

has_exact_synonym

3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid

has_obo_namespace

chebi_ontology

has_related_synonym

3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid

id

CHEBI:85010

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-

inchikey

XDXWLKQMMKQXPV-QYQHSDTDSA-N

label

eltrombopag

mass

442.46660

monoisotopicmass

442.16411

notation

CHEBI:85010

prefLabel

eltrombopag

smiles

CC1=NN(C(=O)C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1

treeView

http://purl.obolibrary.org/obo/CHEBI_26410

http://purl.obolibrary.org/obo/CHEBI_22723

http://purl.obolibrary.org/obo/CHEBI_24631

subClassOf

http://purl.obolibrary.org/obo/CHEBI_26410

http://purl.obolibrary.org/obo/CHEBI_22723

http://purl.obolibrary.org/obo/CHEBI_24631

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http://purl.bioontology.org/ontology/NDDF/012912 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/711942 RXNORM LOOM
http://purl.obolibrary.org/obo/DRON_00019163 DRON LOOM
http://purl.obolibrary.org/obo/dinto_DB06210 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4028105 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000177933 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71634 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/432005001 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C520809 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/C520809 MESH LOOM
http://www.drugbank.ca/drugs/DB06210 FTC LOOM
http://purl.bioontology.org/ontology/UATC/B02BX05 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_85010 NBO SAME_URI
http://purl.bioontology.org/ontology/PDQ/CDR0000491973 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/441995009 SNOMEDCT LOOM