Preferred Name

liraglutide

Synonyms

N2()-(L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl)-N(6)-(N-hexadecanoyl-L-gamma-glutamyl)-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine

Victoza

liraglutida

liraglutide

NN2211

liraglutidum

NN-2211

NN 2211

Definitions

A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

ID

http://purl.obolibrary.org/obo/CHEBI_71193

charge

0

database_cross_reference

PMID:22592020

Drug_Central:4164

PMID:23082308

PMID:23149376

PMID:22846777

Reaxys:10331362

PMID:22973968

KEGG:D06404

Patent:WO2008011518

DrugBank:DB06655

PMID:22382611

PMID:22338093

PMID:22862847

Wikipedia:Liraglutide

PMID:22051096

PMID:22443187

PMID:22587909

Patent:US2006160736

PMID:22245694

PMID:21964769

CAS:204656-20-2

PMID:22938097

PMID:22851600

PMID:22958381

PMID:22727533

PMID:22446097

PMID:22569791

PMID:22405264

PMID:22927782

PMID:23068961

PMID:22985213

PMID:22038829

PMID:22536087

definition

A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

formula

C172H265N43O51

has role

http://purl.obolibrary.org/obo/CHEBI_63726

http://purl.obolibrary.org/obo/CHEBI_71196

has_exact_synonym

N2()-(L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl)-N(6)-(N-hexadecanoyl-L-gamma-glutamyl)-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine

has_obo_namespace

chebi_ontology

has_related_synonym

Victoza

liraglutida

liraglutide

NN2211

liraglutidum

NN-2211

NN 2211

id

CHEBI:71193

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C172H265N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-37-53-129(224)195-116(170(265)266)59-64-128(223)180-68-41-40-50-111(153(248)199-115(62-67-135(232)233)154(249)204-120(73-100-44-33-31-34-45-100)159(254)214-140(93(11)19-2)167(262)192-97(15)146(241)201-122(76-103-79-183-108-49-39-38-48-106(103)108)157(252)203-118(72-90(5)6)158(253)212-138(91(7)8)165(260)200-110(52-43-70-182-172(177)178)149(244)184-81-130(225)193-109(51-42-69-181-171(175)176)148(243)187-84-137(236)237)196-144(239)95(13)189-143(238)94(12)191-152(247)114(58-63-127(174)222)194-131(226)82-185-151(246)113(61-66-134(230)231)198-155(250)117(71-89(3)4)202-156(251)119(75-102-54-56-105(221)57-55-102)205-162(257)124(85-216)208-164(259)126(87-218)209-166(261)139(92(9)10)213-161(256)123(78-136(234)235)206-163(258)125(86-217)210-169(264)142(99(17)220)215-160(255)121(74-101-46-35-32-36-47-101)207-168(263)141(98(16)219)211-132(227)83-186-150(245)112(60-65-133(228)229)197-145(240)96(14)190-147(242)107(173)77-104-80-179-88-188-104/h31-36,38-39,44-49,54-57,79-80,88-99,107,109-126,138-142,183,216-221H,18-30,37,40-43,50-53,58-78,81-87,173H2,1-17H3,(H2,174,222)(H,179,188)(H,180,223)(H,184,244)(H,185,246)(H,186,245)(H,187,243)(H,189,238)(H,190,242)(H,191,247)(H,192,262)(H,193,225)(H,194,226)(H,195,224)(H,196,239)(H,197,240)(H,198,250)(H,199,248)(H,200,260)(H,201,241)(H,202,251)(H,203,252)(H,204,249)(H,205,257)(H,206,258)(H,207,263)(H,208,259)(H,209,261)(H,210,264)(H,211,227)(H,212,253)(H,213,256)(H,214,254)(H,215,255)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,265,266)(H4,175,176,181)(H4,177,178,182)/t93-,94-,95-,96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-,142-/m0/s1

inchikey

YSDQQAXHVYUZIW-QCIJIYAXSA-N

label

liraglutide

mass

3751.20200

monoisotopicmass

3748.946

notation

CHEBI:71193

prefLabel

liraglutide

smiles

CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O

treeView

http://purl.obolibrary.org/obo/CHEBI_46895

http://purl.obolibrary.org/obo/CHEBI_15841

subClassOf

http://purl.obolibrary.org/obo/CHEBI_46895

http://purl.obolibrary.org/obo/CHEBI_15841

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http://purl.bioontology.org/ontology/VANDF/4029703 VANDF LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0000955 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180627 NDFRT LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001545 DMTO LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001502 DMTO LOOM
http://purl.obolibrary.org/obo/DRON_00019617 DRON LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0001545 FASTO LOOM
http://purl.bioontology.org/ontology/NDDF/010773 NDDF LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#liraglutide SDO LOOM
http://www.drugbank.ca/drugs/DB06655 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/444907006 SNOMEDCT LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0000955 FASTO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82239 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82239 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82239 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82239 NCIT LOOM
http://scai.fraunhofer.de/AlzheimerOntology#liraglutide ADO LOOM
http://purl.jp/bio/4/id/201006078991307229 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D000069450 MESH LOOM
http://purl.bioontology.org/ontology/UATC/A10BJ02 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_71193 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_71193 NBO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71193 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_71193 DINTO SAME_URI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C439759 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/475968 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/444828003 SNOMEDCT LOOM