Preferred Name

tesamorelin

Synonyms

GHRH(1-44)

N-[(3E)-hex-3-enoyl]-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-arginyl-L-glutaminyl-L-glutaminylglycyl-L-glutaminyl-L-seryl-L-asparaginyl-L-glutaminyl-L-arginylglycyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-leucinamide

N-[(3E)-1-oxo-3-hexenyl]Somatoliberin (human pancreatic islet)

N-[(3E)-hex-3-enoyl]-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg--Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

Definitions

A polypeptide that is a synthetic analogue of human GRF (Growth Releasing Factor) comprised of the 44 amino-acid sequence of human GRF with a hex-3-enoyl moiety attached to the tyrosine residue at the N-terminal part of the molecule. It is used to stimulate human GRF receptors.

ID

http://purl.obolibrary.org/obo/CHEBI_63626

charge

0

database_cross_reference

PMID:20101189

PMID:21591600

PMID:21516030

PMID:21687371

PMID:22096409

PMID:21695284

PMID:20554713

PMID:22050344

PMID:20943777

PMID:21283099

PMID:21668043

definition

A polypeptide that is a synthetic analogue of human GRF (Growth Releasing Factor) comprised of the 44 amino-acid sequence of human GRF with a hex-3-enoyl moiety attached to the tyrosine residue at the N-terminal part of the molecule. It is used to stimulate human GRF receptors.

formula

C216H360N72O63S

has_exact_synonym

N-[(3E)-hex-3-enoyl]-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-arginyl-L-glutaminyl-L-glutaminylglycyl-L-glutaminyl-L-seryl-L-asparaginyl-L-glutaminyl-L-arginylglycyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-leucinamide

has_obo_namespace

chebi_ontology

has_related_synonym

GHRH(1-44)

N-[(3E)-1-oxo-3-hexenyl]Somatoliberin (human pancreatic islet)

N-[(3E)-hex-3-enoyl]-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg--Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

id

CHEBI:63626

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C216H360N72O63S/c1-25-28-30-53-161(304)256-142(90-118-54-58-120(294)59-55-118)193(334)251-114(21)175(316)271-147(94-165(308)309)194(335)252-115(22)176(317)286-168(109(16)26-2)209(350)279-144(89-117-43-31-29-32-44-117)201(342)288-170(116(23)293)210(351)280-146(93-160(226)303)200(341)284-152(102-292)205(346)275-143(91-119-56-60-121(295)61-57-119)198(339)263-128(51-41-81-244-215(236)237)182(323)262-124(46-34-36-76-218)192(333)285-167(108(14)15)207(348)278-138(85-104(6)7)179(320)248-98-164(307)254-131(63-69-154(220)297)186(327)273-141(88-107(12)13)197(338)283-149(99-289)203(344)253-113(20)174(315)258-126(49-39-79-242-213(232)233)181(322)261-123(45-33-35-75-217)185(326)272-140(87-106(10)11)196(337)274-139(86-105(8)9)195(336)267-135(67-73-158(224)301)190(331)277-148(95-166(310)311)202(343)287-169(110(17)27-3)208(349)269-136(74-83-352-24)191(332)282-150(100-290)204(345)264-129(52-42-82-245-216(238)239)183(324)266-133(65-71-156(222)299)189(330)265-130(62-68-153(219)296)178(319)247-97-163(306)255-132(64-70-155(221)298)187(328)281-151(101-291)206(347)276-145(92-159(225)302)199(340)268-134(66-72-157(223)300)188(329)260-122(47-37-77-240-211(228)229)177(318)246-96-162(305)249-111(18)172(313)257-125(48-38-78-241-212(230)231)180(321)250-112(19)173(314)259-127(50-40-80-243-214(234)235)184(325)270-137(171(227)312)84-103(4)5/h28-32,43-44,54-61,103-116,122-152,167-170,289-295H,25-27,33-42,45-53,62-102,217-218H2,1-24H3,(H2,219,296)(H2,220,297)(H2,221,298)(H2,222,299)(H2,223,300)(H2,224,301)(H2,225,302)(H2,226,303)(H2,227,312)(H,246,318)(H,247,319)(H,248,320)(H,249,305)(H,250,321)(H,251,334)(H,252,335)(H,253,344)(H,254,307)(H,255,306)(H,256,304)(H,257,313)(H,258,315)(H,259,314)(H,260,329)(H,261,322)(H,262,323)(H,263,339)(H,264,345)(H,265,330)(H,266,324)(H,267,336)(H,268,340)(H,269,349)(H,270,325)(H,271,316)(H,272,326)(H,273,327)(H,274,337)(H,275,346)(H,276,347)(H,277,331)(H,278,348)(H,279,350)(H,280,351)(H,281,328)(H,282,332)(H,283,338)(H,284,341)(H,285,333)(H,286,317)(H,287,343)(H,288,342)(H,308,309)(H,310,311)(H4,228,229,240)(H4,230,231,241)(H4,232,233,242)(H4,234,235,243)(H4,236,237,244)(H4,238,239,245)/b30-28+/t109?,110?,111-,112-,113-,114-,115-,116?,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,167-,168-,169-,170-/m0/s1

inchikey

LAJJBLZKAIOLRM-YHAVXTEWSA-N

label

tesamorelin

mass

5005.689

monoisotopicmass

5002.69003

notation

CHEBI:63626

prefLabel

tesamorelin

smiles

C(N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CC(=O)N)C(N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CC(=O)N)C(N[C@H](C(N[C@H](C(=O)NCC(=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H](C(=O)N)CC(C)C)=O)CCCNC(=N)N)C)=O)CCCNC(=N)N)=O)C)CCCNC(N)=N)=O)CCC(=O)N)=O)CO)=O)CCC(=O)N)=O)CCC(=O)N)CCC(=O)N)=O)CCCNC(=N)N)CO)CCSC)=O)C(CC)C)CC(O)=O)=O)CCC(=O)N)=O)CC(C)C)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)C)=O)CO)CC(C)C)=O)CCC(=O)N)CC(C)C)=O)C(C)C)=O)CCCCN)CCCNC(=N)N)=O)CC1=CC=C(C=C1)O)CO)=O)C(O)C)=O)CC2=CC=CC=C2)C(CC)C)=O)C)=O)CC(O)=O)C)([C@H](CC3=CC=C(C=C3)O)NC(C/C=C/CC)=O)=O

treeView

http://purl.obolibrary.org/obo/CHEBI_25905

http://purl.obolibrary.org/obo/CHEBI_15841

subClassOf

http://purl.obolibrary.org/obo/CHEBI_25905

http://purl.obolibrary.org/obo/CHEBI_15841

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http://purl.bioontology.org/ontology/NDFRT/N0000182253 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/448805009 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB08869 DINTO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77425 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77425 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77425 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77425 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77425 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/013567 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_63626 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_63626 NBO SAME_URI
http://purl.bioontology.org/ontology/VANDF/4030295 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/H01AC06 ATC LOOM
http://www.drugbank.ca/drugs/DB08869 FTC LOOM
http://purl.bioontology.org/ontology/RXNORM/1044584 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C479538 RH-MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000182253 ODAE LOOM
http://purl.obolibrary.org/obo/DRON_00020017 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00020017 DRON LOOM
http://purl.bioontology.org/ontology/MESH/C479538 MESH LOOM