Preferred Name

cefditoren

Synonyms

7beta-(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic acid

cefditoren

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Definitions

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

ID

http://purl.obolibrary.org/obo/CHEBI_59343

charge

0

database_cross_reference

Patent:US4839650

DrugBank:DB01066

PMID:22521692

PMID:23009290

Reaxys:8174297

Patent:US2003225265

PMID:29199418

PMID:25871785

PMID:29017833

Beilstein:8174297

KEGG:D07639

PMID:11687308

PMID:22675264

CAS:104145-95-1

PMID:11856949

Patent:EP475610

definition

A broad spectrum, third-generation cephalosporin antibiotic with (Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. Generally administered as its orally absorbed pivaloyloxymethyl ester prodrug, it is used for the treatment of mild to moderate infections caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections.

formula

C19H18N6O5S3

has role

http://purl.obolibrary.org/obo/CHEBI_36047

has_exact_synonym

7beta-(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-3,4-didehydrocepham-4-carboxylic acid

has_obo_namespace

chebi_ontology

has_related_synonym

cefditoren

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

id

CHEBI:59343

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1

inchikey

KMIPKYQIOVAHOP-YLGJWRNMSA-N

label

cefditoren

mass

506.57800

monoisotopicmass

506.05008

notation

CHEBI:59343

prefLabel

cefditoren

smiles

[H][C@]12SCC(\C=C/c3scnc3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O

treeView

http://purl.obolibrary.org/obo/CHEBI_23066

http://purl.obolibrary.org/obo/CHEBI_33575

subClassOf

http://purl.obolibrary.org/obo/CHEBI_23066

http://purl.obolibrary.org/obo/CHEBI_33575

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http://purl.obolibrary.org/obo/CHEBI_59343 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72625 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/LP33348-1 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/83682 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/708598002 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB01066 MDM LOOM
http://purl.bioontology.org/ontology/ATC/J01DD16 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022252 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_59343 GENEPIO LOOM
http://purl.obolibrary.org/obo/ARO_3000649 ARO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016669 LOINC LOOM
http://stirdf.jst.go.jp/id/200907015204427299 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C72625 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#27745 OCHV LOOM
http://purl.jp/bio/4/id/200906067639128915 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0287573 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4024247 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C073460 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026093 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/C073460 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/009507 NDDF LOOM