Preferred Name

ritonavir

Synonyms

N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide

ritonavir

Definitions

An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.

ID

http://purl.obolibrary.org/obo/CHEBI_45409

charge

0

database_cross_reference

PMID:11363517

PMID:11363086

PMID:24202050

LINCS:LSM-5623

Reaxys:768009

PMID:9585800

HMDB:HMDB0014646

Drug_Central:2391

PDBeChem:RIT

PMID:11363184

PMID:11363397

KEGG:C07240

PMID:11363300

PMID:11363329

CAS:155213-67-5

PMID:11996889

PMID:9278209

KEGG:D00427

PMID:9140265

Wikipedia:Ritonavir

PMID:8568292

definition

An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.

formula

C37H48N6O5S2

has role

http://purl.obolibrary.org/obo/CHEBI_35703

http://purl.obolibrary.org/obo/CHEBI_36044

http://purl.obolibrary.org/obo/CHEBI_78298

http://purl.obolibrary.org/obo/CHEBI_35660

has_alternative_id

CHEBI:8873

has_exact_synonym

N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide

has_obo_namespace

chebi_ontology

has_related_synonym

ritonavir

id

CHEBI:45409

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

inchikey

NCDNCNXCDXHOMX-XGKFQTDJSA-N

label

ritonavir

mass

720.94400

monoisotopicmass

720.31276

notation

CHEBI:45409

prefLabel

ritonavir

smiles

CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1

treeView

http://purl.obolibrary.org/obo/CHEBI_38418

http://purl.obolibrary.org/obo/CHEBI_84129

http://purl.obolibrary.org/obo/CHEBI_37622

http://purl.obolibrary.org/obo/CHEBI_23003

http://purl.obolibrary.org/obo/CHEBI_47857

subClassOf

http://purl.obolibrary.org/obo/CHEBI_38418

http://purl.obolibrary.org/obo/CHEBI_84129

http://purl.obolibrary.org/obo/CHEBI_37622

http://purl.obolibrary.org/obo/CHEBI_23003

http://purl.obolibrary.org/obo/CHEBI_47857

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http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
http://purl.obolibrary.org/obo/TXPO_1000327 TXPO LOOM
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http://purl.bioontology.org/ontology/RXNORM/85762 RXNORM LOOM
http://purl.bioontology.org/ontology/UATC/J05AE03 ATC LOOM
http://www.co-ode.org/ontologies/galen#Ritonavir GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019438 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/005554 NDDF LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.675.653 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/4009-0059 CRISP LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386896009 SNOMEDCT LOOM
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http://purl.bioontology.org/ontology/LNC/MTHU013855 LOINC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042665 PDQ LOOM