Preferred Name

dantrolene

Synonyms

Dantrolene

1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione

1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin

dantroleno

dantrolenum

dantrolene

Definitions

The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

ID

http://purl.obolibrary.org/obo/CHEBI_4317

charge

0

database_cross_reference

Beilstein:705189

PMID:29921212

PMID:31901380

PMID:31478931

CAS:7261-97-4

PMID:31775359

PMID:30776519

DrugBank:DB01219

KEGG:C06939

Patent:US3415821

PMID:11934664

PMID:31337666

PMID:31906750

PMID:8797628

PMID:30948257

PMID:18696266

PMID:31918212

PMID:32060500

Patent:NL6612588

PMID:32016838

KEGG:D02347

LINCS:LSM-3823

PMID:31633504

PMID:31851793

definition

The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. A ryanodine receptor antagonist used for the relief of chronic severe spasticity and malignant hyperthermia.

formula

C14H10N4O5

has role

http://purl.obolibrary.org/obo/CHEBI_51371

http://purl.obolibrary.org/obo/CHEBI_146223

http://purl.obolibrary.org/obo/CHEBI_63726

has_exact_synonym

Dantrolene

1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione

has_obo_namespace

chebi_ontology

has_related_synonym

1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin

dantroleno

dantrolenum

dantrolene

id

CHEBI:4317

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)

inchikey

OZOMQRBLCMDCEG-UHFFFAOYSA-N

is conjugate acid of

http://purl.obolibrary.org/obo/CHEBI_59697

label

dantrolene

mass

314.257

monoisotopicmass

314.06512

notation

CHEBI:4317

prefLabel

dantrolene

smiles

C1(NC(=O)CN1N=C(C=2OC(C=3C=CC([N+]([O-])=O)=CC3)=CC2)[H])=O

treeView

http://purl.obolibrary.org/obo/CHEBI_24628

http://purl.obolibrary.org/obo/CHEBI_38532

subClassOf

http://purl.obolibrary.org/obo/CHEBI_24628

http://purl.obolibrary.org/obo/CHEBI_38532

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_4317 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 HOIP SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4317 DRON SAME_URI
http://purl.bioontology.org/ontology/RXNORM/3105 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4317 DRON LOOM
http://purl.bioontology.org/ontology/RCD/x01G2 RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147795 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372819007 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/MESH_D003620 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003620 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D003620 MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C61697 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024810 LOINC LOOM
http://www.drugbank.ca/drugs/DB01219 FTC LOOM
http://purl.bioontology.org/ontology/CSP/1548-7165 CRISP LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018188 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP17990-0 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61697 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3607 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Dantrolene GALEN LOOM
https://go.drugbank.com/drugs/DB01219 MDM LOOM
http://purl.obolibrary.org/obo/OMIT_0004903 OMIT LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Dantrolene STMSO LOOM
http://purl.bioontology.org/ontology/ATC/M03CA01 ATC LOOM
http://stirdf.jst.go.jp/id/200907017160134437 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010976 OCHV LOOM
http://purl.jp/bio/4/id/200906018264327051 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019703 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-687D0 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.432.555.287 RH-MESH LOOM