Preferred Name |
cerivastatin |
|
Synonyms |
Cerivastatin (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoic acid (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid (3R,5S,6E)-7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic acid cerivastatin cerivastatin acid |
|
Definitions |
(3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_3558 |
|
charge |
0 |
|
database_cross_reference |
PMID:18155906 PMID:17560788 Drug_Central:577 Beilstein:8366578 KEGG:D07661 CAS:145599-86-6 Wikipedia:Cerivastatin DrugBank:DB00439 KEGG:C07966 |
|
definition |
(3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity. |
|
formula |
C26H34FNO5 |
|
has_alternative_id |
CHEBI:503465 |
|
has_exact_synonym |
Cerivastatin (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
(3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoic acid (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid (3R,5S,6E)-7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic acid cerivastatin cerivastatin acid |
|
id |
CHEBI:3558 |
|
in_subset | ||
inchi |
InChI=1S/C26H34FNO5/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32)/b11-10+/t19-,20-/m1/s1 |
|
inchikey |
SEERZIQQUAZTOL-ANMDKAQQSA-N |
|
is conjugate acid of | ||
label |
cerivastatin |
|
mass |
459.55030 |
|
monoisotopicmass |
459.24210 |
|
notation |
CHEBI:3558 |
|
prefLabel |
cerivastatin |
|
smiles |
COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)c1-c1ccc(F)cc1)C(C)C |
|
treeView |
http://purl.obolibrary.org/obo/CHEBI_87635 |
|
subClassOf |
http://purl.obolibrary.org/obo/CHEBI_87635 |