Preferred Name |
butenafine |
|
Synonyms |
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine Butenafine (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine butenafina butenafinum 4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine butenafine N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine |
|
Definitions |
Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_3238 |
|
charge |
0 |
|
database_cross_reference |
KEGG:D07596 CAS:101828-21-1 DrugBank:DB01091 KEGG:C08067 LINCS:LSM-5956 PMID:17371821 Drug_Central:444 Beilstein:6334654 Patent:US5021458 Patent:EP164697 Wikipedia:Butenafine PMID:8340915 |
|
definition |
Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections. |
|
formula |
C23H27N |
|
has role | ||
has_alternative_id |
CHEBI:205442 |
|
has_exact_synonym |
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine Butenafine |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
(4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine butenafina butenafinum 4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine butenafine N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine |
|
id |
CHEBI:3238 |
|
in_subset | ||
inchi |
InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3 |
|
inchikey |
ABJKWBDEJIDSJZ-UHFFFAOYSA-N |
|
label |
butenafine |
|
mass |
317.46720 |
|
monoisotopicmass |
317.21435 |
|
notation |
CHEBI:3238 |
|
prefLabel |
butenafine |
|
smiles |
CN(Cc1ccc(cc1)C(C)(C)C)Cc1cccc2ccccc12 |
|
treeView | ||
subClassOf |