Preferred Name

butenafine

Synonyms

1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine

Butenafine

(4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine

butenafina

butenafinum

4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine

butenafine

N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine

(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine

Definitions

Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.

ID

http://purl.obolibrary.org/obo/CHEBI_3238

charge

0

database_cross_reference

KEGG:D07596

CAS:101828-21-1

DrugBank:DB01091

KEGG:C08067

LINCS:LSM-5956

PMID:17371821

Drug_Central:444

Beilstein:6334654

Patent:US5021458

Patent:EP164697

Wikipedia:Butenafine

PMID:8340915

definition

Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.

formula

C23H27N

has role

http://purl.obolibrary.org/obo/CHEBI_59285

http://purl.obolibrary.org/obo/CHEBI_86327

has_alternative_id

CHEBI:205442

has_exact_synonym

1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine

Butenafine

has_obo_namespace

chebi_ontology

has_related_synonym

(4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine

butenafina

butenafinum

4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine

butenafine

N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine

(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine

id

CHEBI:3238

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3

inchikey

ABJKWBDEJIDSJZ-UHFFFAOYSA-N

label

butenafine

mass

317.46720

monoisotopicmass

317.21435

notation

CHEBI:3238

prefLabel

butenafine

smiles

CN(Cc1ccc(cc1)C(C)(C)C)Cc1cccc2ccccc12

treeView

http://purl.obolibrary.org/obo/CHEBI_32876

http://purl.obolibrary.org/obo/CHEBI_25477

subClassOf

http://purl.obolibrary.org/obo/CHEBI_32876

http://purl.obolibrary.org/obo/CHEBI_25477

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_3238 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3238 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3238 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3238 DRON SAME_URI
http://purl.bioontology.org/ontology/NDFRT/N0000022059 NDFRT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72959 NCIT LOOM
http://purl.obolibrary.org/obo/dinto_DB01091 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4024054 VANDF LOOM
http://purl.jp/bio/4/id/200906095176800248 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/C067594 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16175 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C72959 BERO LOOM
http://stirdf.jst.go.jp/id/200907088578946092 IOBC LOOM
http://www.drugbank.ca/drugs/DB01091 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/006293 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373449007 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB01091 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_3238 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3238 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3238 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3238 DRON LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025790 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0107497 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/47461 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/D01AE23 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067594 RH-MESH LOOM