Preferred Name

trioxsalen

Synonyms

6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone

Trioxsalen

trioxisaleno

trioxysalene

trioxysalenum

Trioxysalen

2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one

Trimethylpsoralen

4,8,5'-Trimethylpsoralen

trioxysalen

4,5',8-Trimethylpsoralen

2',4,8-Trimethylpsoralen

Definitions

7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

ID

http://purl.obolibrary.org/obo/CHEBI_28329

charge

0

database_cross_reference

KEGG:D01034

Drug_Central:2759

Patent:US3201421

Wikipedia:Trioxsalen

Beilstein:221723

LINCS:LSM-3223

CAS:3902-71-4

KEGG:C09314

DrugBank:DB04571

KNApSAcK:C00002502

definition

7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

formula

C14H12O3

has role

http://purl.obolibrary.org/obo/CHEBI_50177

http://purl.obolibrary.org/obo/CHEBI_47868

has_alternative_id

CHEBI:20282

CHEBI:1758

has_exact_synonym

Trioxsalen

2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one

has_obo_namespace

chebi_ontology

has_related_synonym

6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone

trioxisaleno

trioxysalene

trioxysalenum

Trioxysalen

Trimethylpsoralen

4,8,5'-Trimethylpsoralen

trioxysalen

4,5',8-Trimethylpsoralen

2',4,8-Trimethylpsoralen

id

CHEBI:28329

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3

inchikey

FMHHVULEAZTJMA-UHFFFAOYSA-N

label

trioxsalen

mass

228.24328

monoisotopicmass

228.079

notation

CHEBI:28329

prefLabel

trioxsalen

smiles

Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1

treeView

http://purl.obolibrary.org/obo/CHEBI_26369

subClassOf

http://purl.obolibrary.org/obo/CHEBI_26369

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66640 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66640 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66640 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66640 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_28329 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28329 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28329 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_28329 NBO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28329 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_28329 DINTO SAME_URI
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http://purl.bioontology.org/ontology/NDFRT/N0000147178 NDFRT LOOM
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http://purl.bioontology.org/ontology/SNOMEDCT/35464001 SNOMEDCT LOOM