Preferred Name

adefovir

Synonyms

GS-0393

HSDB 8079

DRG-0156

{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid

PMEA

9-(2-(Phosphonomethoxy)ethyl)adenine

Adefovir

9-(2-Phosphonylmethoxyethyl)adenine

N-(2-Phosphonylmethoxyethyl)adenine

GS 0393

GS 393

Definitions

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.

ID

http://purl.obolibrary.org/obo/CHEBI_2469

charge

0

database_cross_reference

PMID:22976988

PMID:28123560

PMID:27698751

PMID:27664568

PMID:27746441

PMID:11796353

PMID:28011962

PMID:24338503

PMID:14978283

CAS:106941-25-7

PMID:28436380

Beilstein:3561094

PDBeChem:5HG

PMID:27806120

PMID:27649318

PMID:28081595

PMID:14647052

PMID:27381944

KEGG:C11277

PMID:28079295

Reaxys:3561094

PMID:27880997

PMID:10676990

Wikipedia:Adefovir

KEGG:D02768

DrugBank:DB00718

PMID:15866657

PMID:27858892

PMID:27977591

PMID:27079793

PMID:28397817

PMID:27729626

PMID:28322924

definition

A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.

formula

C8H12N5O4P

has functional parent

http://purl.obolibrary.org/obo/CHEBI_16708

has role

http://purl.obolibrary.org/obo/CHEBI_50909

http://purl.obolibrary.org/obo/CHEBI_49103

http://purl.obolibrary.org/obo/CHEBI_36044

http://purl.obolibrary.org/obo/CHEBI_59517

http://purl.obolibrary.org/obo/CHEBI_53756

has_alternative_id

CHEBI:40188

has_exact_synonym

{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid

Adefovir

has_obo_namespace

chebi_ontology

has_related_synonym

GS-0393

HSDB 8079

DRG-0156

PMEA

9-(2-(Phosphonomethoxy)ethyl)adenine

9-(2-Phosphonylmethoxyethyl)adenine

N-(2-Phosphonylmethoxyethyl)adenine

GS 0393

GS 393

id

CHEBI:2469

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)

inchikey

SUPKOOSCJHTBAH-UHFFFAOYSA-N

is conjugate acid of

http://purl.obolibrary.org/obo/CHEBI_134512

label

adefovir

mass

273.186

monoisotopicmass

273.06269

notation

CHEBI:2469

prefLabel

adefovir

smiles

N1(C2=C(C(N)=NC=N2)N=C1)CCOCP(O)(=O)O

treeView

http://purl.obolibrary.org/obo/CHEBI_26069

http://purl.obolibrary.org/obo/CHEBI_20706

http://purl.obolibrary.org/obo/CHEBI_25698

subClassOf

http://purl.obolibrary.org/obo/CHEBI_26069

http://purl.obolibrary.org/obo/CHEBI_20706

http://purl.obolibrary.org/obo/CHEBI_25698

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/LNC/LP28549-1 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0050175 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/009376 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_2469 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2469 BIOMODELS SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61526 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022290 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/412072006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013860 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C053001 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/16521 RXNORM LOOM
http://purl.obolibrary.org/obo/HIV_5674 HIV LOOM
http://purl.bioontology.org/ontology/MESH/C053001 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13401 OCHV LOOM
http://purl.obolibrary.org/obo/DRON_00016642 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00016642 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00016642 DRON LOOM
http://purl.bioontology.org/ontology/VANDF/4024286 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/5001-0019 CRISP LOOM