loading...| Preferred Name |
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| Synonyms |
ALS Gehrigs Disease Dementia With Amyotrophic Lateral Sclerosis ALS - Amyotrophic lateral sclerosis Bulbar motor neuron disease GEHRIGS DIS Gehrig's Disease AMYOTROPHIC SCLEROSIS Lou-Gehrigs Disease Lou Gehrigs Disease Sclerosis, Amyotrophic Lateral Motor neuron disease, bulbar Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 Amyotrophic Lateral Sclerosis, Guam Form Guam Form of Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis (disorder) Lou Gehrig's Disease Lou Gehrig Disease MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS Lateral Scleroses, Amyotrophic ALS (Amyotrophic Lateral Sclerosis) Gehrig Disease Amyotrophic Lateral Sclerosis With Dementia Amyotrophic lateral sclerosis, Parkinsonism/Dementia complex of Guam LOU GEHRIG DIS Motor Neuron Disease, Amyotrophic Lateral Sclerosis Disease, Lou-Gehrigs Charcot disease LOU GEHRIGS DIS |
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| Definitions |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). An autosomal dominant inherited form of amyloidosis. A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) |
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| ID |
http://www.ebi.ac.uk/efo/EFO_0000253 |
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| Obsolete |
true |
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| database_cross_reference |
OMIM:617839 OMIM:616208 NCIt:C34373 ORDO:Orphanet_803 MeSH:D000690 NIFSTD:birnlex_12566 OMIM:105400 OMIM:617892 SNOMEDCT:86044005 MedDRA:10002026 OMIM:617921 MedDRA:10052889 OMIM:105500 ICD9:335.20 DOID:332 |
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| definition |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts (MeSH). An autosomal dominant inherited form of amyloidosis. A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) |
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| deprecated |
true |
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| has_exact_synonym |
LOU GEHRIGS DIS Charcot disease Disease, Lou-Gehrigs Motor Neuron Disease, Amyotrophic Lateral Sclerosis LOU GEHRIG DIS Amyotrophic lateral sclerosis, Parkinsonism/Dementia complex of Guam Amyotrophic Lateral Sclerosis With Dementia Gehrig Disease ALS (Amyotrophic Lateral Sclerosis) Lateral Scleroses, Amyotrophic MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS Lou Gehrig Disease Lou Gehrig's Disease Amyotrophic lateral sclerosis (disorder) Guam Form of Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis, Guam Form Amyotrophic Lateral Sclerosis-Parkinsonism/dementia Complex 1 Motor neuron disease, bulbar Sclerosis, Amyotrophic Lateral Lou Gehrigs Disease Lou-Gehrigs Disease AMYOTROPHIC SCLEROSIS Gehrig's Disease GEHRIGS DIS Bulbar motor neuron disease ALS - Amyotrophic lateral sclerosis Dementia With Amyotrophic Lateral Sclerosis Gehrigs Disease ALS |
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| label |
obsolete_amyotrophic lateral sclerosis |
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| obsoleted_in_version |
3.38.0 |
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| organizational_class |
true |
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| prefixIRI |
efo1:EFO_0000253 |
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| reason_for_obsolescence |
Replaced with Mondo term see https://github.com/ebispot/efo/issues/1381 |
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| term editor |
Tomasz Adamusiak James Malone Gautier Koscielny |
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| term replaced by | ||
| subClassOf |