loading...| Preferred Name |
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| Synonyms |
epencephalon-1 infratentorial region parencephalon corpus cerebelli |
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| Definitions |
Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0002037 |
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| database_cross_reference |
UMLS:C1268981 AAO:0010485 ZFA:0000100 EHDAA2:0000232 NCIT:C12445 EMAPA:17787 CALOHA:TS-0125 BTO:0000232 MIAA:0000110 XAO:0003098 VHOG:0000024 MAT:0000110 Wikipedia:Cerebellum SCTID:180924008 UMLS:C0007765 neuronames:643 BIRNLEX:1489 TAO:0000100 MESH:D002531 EFO:0000327 BAMS:CB BAMS:Cb BM:CB DHBA:10656 EV:0100293 FMA:67944 GAID:595 HBA:4696 MA:0000198 MBA:512 |
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| definition |
Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. |
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| depiction |
https://upload.wikimedia.org/wikipedia/commons/a/a7/Cerebellum_NIH.png |
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| dubious_for_taxon | ||
| external_definition |
Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO] Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO] |
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| external_ontology_notes |
almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem |
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| has_broad_synonym |
infratentorial region |
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| has_exact_synonym |
epencephalon-1 |
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| has_obo_namespace |
uberon |
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| has_related_synonym |
parencephalon corpus cerebelli |
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| has_relational_adjective |
cerebellar |
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| homology_notes |
However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG] |
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| id |
UBERON:0002037 |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/uberon/core#efo_slim http://purl.obolibrary.org/obo/uberon/core#vertebrate_core |
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| label |
cerebellum |
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| never_in_taxon | ||
| notation |
UBERON:0002037 |
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| part_of |
http://purl.obolibrary.org/obo/UBERON_0002028 |
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| RO_0002171 | ||
| RO_0002175 | ||
| taxon_notes |
The absence of a cerebellum in hagfishes and lampreys appears to be the only exception [to the rule that vertebrates possess the same number of brain divisions]. Both hagfishes and lampreys do possess a thin band of cells located medial to the lateral line centers of the medulla (Ronan and Northcutt, 1998), which has been interpreted as a primitive cerebellum (Larsell, 1967), but more recent experimental studies (Kishida et al., 1987; Weigle and Northcutt, 1998) fail to support Larsell's claim[http://icb.oxfordjournals.org/content/42/4/743.full] |
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| treeView |
http://purl.obolibrary.org/obo/UBERON_0002028 |
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| subClassOf |