Preferred Name |
edrophonium |
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Synonyms |
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Definitions |
N-Ethyl-N,N-dimethylanilinium in which on of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. |
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ID |
http://purl.obolibrary.org/obo/CHEBI_251408 |
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alternative term |
EDROPHONIUM ION 3-hydroxy-N,N-dimethyl-N-ethylanilinium CC[N+](C)(C)c1cccc(O)c1 EDROPHONIUM InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O edrophonium Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium C10H16NO InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1 Edrophonium (3-hydroxyphenyl)dimethylethylammonium N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium N-ethyl-3-hydroxy-N,N-dimethylanilinium |
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definition |
N-Ethyl-N,N-dimethylanilinium in which on of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. |
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has role |
http://purl.obolibrary.org/obo/CHEBI_50247 |
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label |
edrophonium |
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prefixIRI |
CHEBI:251408 |
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prefLabel |
edrophonium |
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subClassOf |