BioModels Ontology

Last uploaded: April 3, 2012
Preferred Name

edrophonium

Synonyms
Definitions

N-Ethyl-N,N-dimethylanilinium in which on of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.

ID

http://purl.obolibrary.org/obo/CHEBI_251408

alternative term

EDROPHONIUM ION

3-hydroxy-N,N-dimethyl-N-ethylanilinium

CC[N+](C)(C)c1cccc(O)c1

EDROPHONIUM

InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O

edrophonium

Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium

C10H16NO

InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1

Edrophonium

(3-hydroxyphenyl)dimethylethylammonium

N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium

N-ethyl-3-hydroxy-N,N-dimethylanilinium

definition

N-Ethyl-N,N-dimethylanilinium in which on of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.

has role

http://purl.obolibrary.org/obo/CHEBI_50247

http://purl.obolibrary.org/obo/CHEBI_33295

http://purl.obolibrary.org/obo/CHEBI_37733

label

edrophonium

prefixIRI

CHEBI:251408

prefLabel

edrophonium

subClassOf

http://purl.obolibrary.org/obo/CHEBI_33853

http://purl.obolibrary.org/obo/CHEBI_35267

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http://purl.obolibrary.org/obo/CHEBI_251408 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_251408 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_251408 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_251408 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_251408 CHEBI SAME_URI
http://stirdf.jst.go.jp/id/200907073352757796 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.675.276.352 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4271 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.877.674.333 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB01010 FTC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76137 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004491 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147833 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-67160 SNMI LOOM
http://purl.jp/bio/4/id/200906050824034498 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016070 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RCD/x01DJ RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/3752 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/V04CX07 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0013615 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0005742 OMIT LOOM
http://purl.obolibrary.org/obo/NCIT_C76137 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4019741 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D004491 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373342004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_251408 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_251408 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_251408 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_251408 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_251408 CHEBI LOOM
https://go.drugbank.com/drugs/DB01010 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D004491 BERO LOOM